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公开(公告)号：US10941161B2
公开(公告)日：2021-03-09
申请号：US16291893
申请日：2019-03-04
IPC分类号： C07D501/04 , C07D501/56 , C07D501/24 , C07D501/54
摘要： Described herein are crystalline forms of a compound of formula (III′), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.
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公开(公告)号：US20170129906A1
公开(公告)日：2017-05-11
申请号：US15319104
申请日：2015-06-19
IPC分类号： C07D501/04 , C07D285/08
CPC分类号： C07D501/04 , C07D285/08
摘要： This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.
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公开(公告)号：US20190225624A1
公开(公告)日：2019-07-25
申请号：US16291893
申请日：2019-03-04
IPC分类号： C07D501/56 , C07D501/54 , C07D501/24 , C07D501/04
摘要： Described herein are crystalline forms of a compound of formula (III′), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.
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公开(公告)号：US20170226126A1
公开(公告)日：2017-08-10
申请号：US15503564
申请日：2015-08-14
IPC分类号： C07D501/56 , C07D501/04 , C07D501/24
CPC分类号： C07D501/56 , C07B2200/13 , C07D501/04 , C07D501/24 , C07D501/54 , Y02P20/55
摘要： Described herein are crystalline forms of a compound of formula (III−), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (III−): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.
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公开(公告)号：US10221196B2
公开(公告)日：2019-03-05
申请号：US15503564
申请日：2015-08-14
IPC分类号： C07D501/56 , C07D501/04 , C07D501/24
摘要： Described herein are crystalline forms of a compound of formula (IIΓ), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (IIΓ): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.
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公开(公告)号：US10214543B2
公开(公告)日：2019-02-26
申请号：US15540283
申请日：2015-12-18
IPC分类号： C07D501/56 , C07D417/14 , C07B43/04 , C07B43/06 , C07B51/00
摘要： Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.
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公开(公告)号：US09695196B2
公开(公告)日：2017-07-04
申请号：US15319104
申请日：2015-06-19
IPC分类号： C07D501/04 , C07D285/08
CPC分类号： C07D501/04 , C07D285/08
摘要： This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.
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