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公开(公告)号：US10221196B2
公开(公告)日：2019-03-05
申请号：US15503564
申请日：2015-08-14
IPC分类号： C07D501/56 , C07D501/04 , C07D501/24
摘要： Described herein are crystalline forms of a compound of formula (IIΓ), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (IIΓ): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.
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公开(公告)号：US10214543B2
公开(公告)日：2019-02-26
申请号：US15540283
申请日：2015-12-18
IPC分类号： C07D501/56 , C07D417/14 , C07B43/04 , C07B43/06 , C07B51/00
摘要： Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.
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公开(公告)号：US09872906B2
公开(公告)日：2018-01-23
申请号：US14856075
申请日：2015-09-16
发明人： Joseph Terracciano , Nicole Miller Damour , Chun Jiang , Giovanni Fogliato , Giuseppe Alessandro Donadelli , Dario Resemini
IPC分类号： A61K31/431 , A61K31/546 , A61K47/02 , A61K9/00 , A61K47/18 , A61K9/19 , A61K47/12
CPC分类号： A61K47/02 , A61K9/0019 , A61K9/19 , A61K31/431 , A61K31/546 , A61K47/12 , A61K47/183 , A61K2300/00
摘要： This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.
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公开(公告)号：US20160279140A1
公开(公告)日：2016-09-29
申请号：US15086479
申请日：2016-03-31
发明人： Joseph Terracciano , Nicole Miller Damour , Chun Jiang , Giovanni Fogliato , Giuseppe Alessandro Donadelli , Dario Resemini
IPC分类号： A61K31/546 , A61K47/26 , A61K47/02 , A61K31/431 , A61K9/00
摘要： This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.
摘要翻译： 本公开提供了包含头孢噻吩的药物组合物，包括头孢噻吩和他唑巴坦的药物组合物，制备这些组合物的方法，以及这些组合物的相关方法和用途。
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公开(公告)号：US10941161B2
公开(公告)日：2021-03-09
申请号：US16291893
申请日：2019-03-04
IPC分类号： C07D501/04 , C07D501/56 , C07D501/24 , C07D501/54
摘要： Described herein are crystalline forms of a compound of formula (III′), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.
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公开(公告)号：US20190225624A1
公开(公告)日：2019-07-25
申请号：US16291893
申请日：2019-03-04
IPC分类号： C07D501/56 , C07D501/54 , C07D501/24 , C07D501/04
摘要： Described herein are crystalline forms of a compound of formula (III′), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.
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公开(公告)号：US09925196B2
公开(公告)日：2018-03-27
申请号：US15071530
申请日：2016-03-16
发明人： Joseph Terracciano , Nicole Miller Damour , Chun Jiang , Giovanni Fogliato , Giuseppe Alessandro Donadelli , Dario Resemini
IPC分类号： A61K31/545 , A61K31/43 , A61K31/546 , A61K9/19 , A61K31/431 , A61K47/02 , A61K47/12 , A61K47/18 , A61K31/198
CPC分类号： A61K31/546 , A61K9/19 , A61K31/198 , A61K31/43 , A61K31/431 , A61K31/545 , A61K47/02 , A61K47/12 , A61K47/183 , A61K2300/00
摘要： Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane prepared in the absence of tazobactam, tazobactam prepared in the absence of ceftolozane, and/or compositions where ceftolozane and tazobactam are first combined within a unit dosage form container.
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公开(公告)号：US20170226126A1
公开(公告)日：2017-08-10
申请号：US15503564
申请日：2015-08-14
IPC分类号： C07D501/56 , C07D501/04 , C07D501/24
CPC分类号： C07D501/56 , C07B2200/13 , C07D501/04 , C07D501/24 , C07D501/54 , Y02P20/55
摘要： Described herein are crystalline forms of a compound of formula (III−), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (III−): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.
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公开(公告)号：US11278622B2
公开(公告)日：2022-03-22
申请号：US16574825
申请日：2019-09-18
发明人： Joseph Terracciano , Nicole Miller Damour , Chun Jiang , Giovanni Fogliato , Giuseppe Alessandron Donadelli , Dario Resemini
IPC分类号： A61K47/02 , A61K31/546 , A61K31/431 , A61K9/00 , A61K47/18 , A61K9/19 , A61K47/12
摘要： This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.
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公开(公告)号：US10420841B2
公开(公告)日：2019-09-24
申请号：US15844961
申请日：2017-12-18
发明人： Joseph Terracciano , Nicole Miller Damour , Chun Jiang , Giovanni Fogliato , Giuseppe Alessandron Donadelli , Dario Resemini
IPC分类号： A61K31/431 , A61K31/546 , A61K47/02 , A61K9/00 , A61K47/18 , A61K9/19 , A61K47/12
摘要： This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.
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