公开(公告)号：US11230547B2

公开(公告)日：2022-01-25

申请号：US16764448

申请日：2018-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Meredeth A. McGowan ,  Jason D. Katz ,  Matthew Christopher ,  Hua Zhou ,  David James Witter ,  Chaomin Li ,  John Lampe ,  Joey L. Methot ,  Abdelghani A. Achab ,  Xavier Fradera ,  Shimin Xu

IPC: C07D487/08 ,  C07D519/00 ,  C07D403/14

Abstract: The instant invention provides compounds of formulas Ia and Ib which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

公开(公告)号：US11179389B2

公开(公告)日：2021-11-23

申请号：US16764107

申请日：2018-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Meredeth A. McGowan ,  Jason D. Katz ,  Hua Zhou ,  David James Witter ,  Chaomin Li ,  Kathryn A. Lipford ,  Joey L. Methot ,  Abdelghani A. Achab ,  Xavier Fradera ,  Shimin Xu ,  Jianmin Fu

IPC: A61K31/497 ,  C07D471/10 ,  C07D498/10 ,  C07D403/14 ,  C07D401/14 ,  C07D413/14 ,  A61K31/5386 ,  A61K31/5377 ,  C07D491/107

Abstract: The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.