公开(公告)号：US20170158701A1

公开(公告)日：2017-06-08

申请号：US15325100

申请日：2015-07-16

Applicant: Merck Sharp & Dohme Corp.

Inventor： John Y. L. Chung ,  Feng Peng ,  Yonggang Chen ,  Amude Mahmoud Kassim ,  Cheng-yi Chen ,  Mathew Maust ,  Mark McLaughlin ,  Michael J. Zacuto ,  Qinghao Chen ,  Lushi Tan ,  Zhiguo Jake Song ,  Yang Cao ,  Feng Xu

IPC: C07D487/04 ,  A61K31/4162

CPC classification number: C07D487/04 ,  A61K31/4162 ,  C07D309/30

Abstract: A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of, reductive amination of:

公开(公告)号：US09862725B2

公开(公告)日：2018-01-09

申请号：US15325100

申请日：2015-07-16

Applicant: Merck Sharp & Dohme Corp.

Inventor： John Y. L. Chung ,  Feng Peng ,  Yonggang Chen ,  Amude Mahmoud Kassim ,  Cheng-yi Chen ,  Mathew Maust ,  Mark McLaughlin ,  Michael J. Zacuto ,  Qinghao Chen ,  Lushi Tan ,  Zhiguo Jake Song ,  Yang Cao ,  Feng Xu

IPC: C07D231/56 ,  C07D405/04 ,  C07C69/73 ,  C07F5/04 ,  C07D487/04 ,  A61K31/4162

CPC classification number: C07D487/04 ,  A61K31/4162 ,  C07D309/30

Abstract: A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of, reductive amination of:

公开(公告)号：US20180093992A1

公开(公告)日：2018-04-05

申请号：US15831895

申请日：2017-12-05

Applicant: Merck Sharp & Dohme Corp.

Inventor： John Y. L. Chung ,  Feng Peng ,  Yonggang Chen ,  Amude Mahmoud Kassim ,  Cheng-yi Chen ,  Mathew Maust ,  Mark McLaughlin ,  Michael J. Zacuto ,  Qinghao Chen ,  Lushi Tan ,  Zhiguo Jake Song ,  Yang Cao ,  Feng Xu

IPC: C07D487/04 ,  A61K31/4162

CPC classification number: C07D487/04 ,  A61K31/4162 ,  C07D309/30

Abstract: A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of:  and reductive amination of:

公开(公告)号：US10053466B2

公开(公告)日：2018-08-21

申请号：US15831895

申请日：2017-12-05

Applicant: Merck Sharp & Dohme Corp.

Inventor： John Y. L. Chung ,  Feng Peng ,  Yonggang Chen ,  Amude Mahmoud Kassim ,  Cheng-yi Chen ,  Mathew Maust ,  Mark McLaughlin ,  Michael J. Zacuto ,  Qinghao Chen ,  Lushi Tan ,  Zhiguo Jake Song ,  Yang Cao ,  Feng Xu

IPC: C07D487/04 ,  A61K31/4162

Abstract: A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of:  and reductive amination of:

公开(公告)号：US09725464B2

公开(公告)日：2017-08-08

申请号：US15032552

申请日：2014-10-24

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Ian Mangion ,  Cheng-yi Chen ,  Ingyu Jeon ,  Yonggang Chen ,  Hongmei Li ,  Hoa N. Nguyen ,  Peter E. Maligres ,  Artis Klapars ,  Ilia Zavialov ,  Nobuyoshi Yasuda

IPC: C07D498/04 ,  C07D403/04 ,  C07C215/50 ,  C07F5/02 ,  C07C213/02

CPC classification number: C07D498/04 ,  C07C213/02 ,  C07C215/50 ,  C07D403/04 ,  C07F5/025

Abstract: The present invention is directed to a process for preparing Tetracyclic Heterocycle Compounds of formula (I): which are useful as HCV NS5A inhibitors. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

公开(公告)号：US20160257698A1

公开(公告)日：2016-09-08

申请号：US15032552

申请日：2014-10-24

Applicant: Merck Sharp & Dohme Corp.

Inventor： Ian Mangion ,  Cheng-yi Chen ,  Ingyu Jeon ,  Yonggang Chen ,  Hongmei Li ,  Hoa N. Nguyen ,  Peter E. Maligres ,  Artis Klapars ,  Ilia Zavialov ,  Nobuyoshi Yasuda

IPC: C07D498/04 ,  C07D403/04 ,  C07C213/02

CPC classification number: C07D498/04 ,  C07C213/02 ,  C07C215/50 ,  C07D403/04 ,  C07F5/025

Abstract: The present invention is directed to a process for preparing Tetracyclic Heterocycle Compounds of formula (I): which are useful as HCV NS5A inhibitors. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

Abstract translation: 本发明涉及制备式（I）的四环杂环化合物的方法：其可用作HCV NS5A抑制剂。 本发明还涉及可用作制备式（I）化合物的合成中间体的化合物。