公开(公告)号：US20190023810A1

公开(公告)日：2019-01-24

申请号：US16065917

申请日：2016-12-28

Applicant: Massachusetts Institute of Technology

Inventor： Ram SASISEKHARAN ,  Kannan THARAKARAMAN ,  Vidya SUBRAMANIAN ,  Eduardo FLEISCHER ,  Andrew Peter HATAS

IPC: C07K16/46 ,  C07K16/32 ,  C07K16/28 ,  C07K16/22

Abstract: Described herein are mutations in the CHl/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20210095007A1

公开(公告)日：2021-04-01

申请号：US17112581

申请日：2020-12-04

Applicant: Massachusetts Institute of Technology

Inventor： Ram SASISEKHARAN ,  Kannan THARAKARAMAN ,  Devin QUINLAN ,  Vidya SUBRAMANIAN

IPC: C07K16/10 ,  A61K38/21 ,  A61K39/42

Abstract: Isolated monoclonal antibodies which bind to Ebola virus glycoprotein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20210009663A1

公开(公告)日：2021-01-14

申请号：US17034840

申请日：2020-09-28

Applicant: Massachusetts Institute of Technology ,  National University of Singapore

Inventor： Ram SASISEKHARAN ,  Kannan THARAKARAMAN ,  Kuan Rong CHAN ,  Satoru WATANABE ,  Subhash G. VASUDEVAN ,  Eng Eong OOI

IPC: C07K16/10 ,  A61K39/395 ,  A61K39/12 ,  C07K14/18 ,  A61P31/12 ,  A61K39/42 ,  A61P31/14 ,  C12N15/63

Abstract: Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20170089898A1

公开(公告)日：2017-03-30

申请号：US15291199

申请日：2016-10-12

Applicant: Massachusetts Institute of Technology

Inventor： Ram SASISEKHARAN ,  Luke Nathaniel ROBINSON ,  Kannan THARAKARAMAN

IPC: G01N33/569 ,  C07K16/10

CPC classification number: G01N33/56983 ,  C07K16/10 ,  C07K16/1081 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/185 ,  G01N2469/10

Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.

公开(公告)号：US20190315838A1

公开(公告)日：2019-10-17

申请号：US16341845

申请日：2017-10-13

Applicant: Massachusetts Institute of Technology ,  National University of Singapore

Inventor： Ram SASISEKHARAN ,  Kannan THARAKARAMAN ,  Kuan Rong CHAN ,  Satoru WATANABE ,  Subhash G. VASUDEVAN ,  Eng Eong OOI

IPC: C07K16/10 ,  A61P31/14 ,  C07K14/18 ,  A61K39/12 ,  A61K39/395 ,  C12N15/63

Abstract: Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20180105583A1

公开(公告)日：2018-04-19

申请号：US15783655

申请日：2017-10-13

Applicant: Massachusetts Institute of Technology ,  National University of Singapore

Inventor： Ram SASISEKHARAN ,  Kannan THARAKARAMAN ,  Kuan Rong CHAN ,  Satoru WATANABE ,  Subhash G. VASUDEVAN ,  Eng Eong OOI

IPC: C07K16/10 ,  A61P31/14 ,  C12N15/63

Abstract: Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20170298120A1

公开(公告)日：2017-10-19

申请号：US15515746

申请日：2015-10-02

Applicant: Massachusetts Institute of Technology

Inventor： Ram SASISEKHARAN ,  Kannan THARAKARAMAN ,  Devin QUINLAN ,  Vidya SUBRAMANIAN

IPC: C07K16/10 ,  A61K38/21 ,  A61K39/42 ,  A61K39/00

CPC classification number: C07K16/10 ,  A61K38/212 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/50 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2760/14122

Abstract: Isolated monoclonal antibodies which bind to Ebola virus glycoprotein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20150110825A1

公开(公告)日：2015-04-23

申请号：US14495640

申请日：2014-09-24

Applicant: Massachusetts Institute of Technology

Inventor： Ram SASISEKHARAN ,  Aditya RAGURAM ,  Vidya SUBRAMANIAN

IPC: A61K39/155 ,  A61K47/48 ,  C07K14/00 ,  C12N7/00 ,  C07K14/205

CPC classification number: A61K39/155 ,  A61K39/02 ,  A61K39/12 ,  A61K47/6931 ,  C07K14/00 ,  C07K14/135 ,  C07K14/205 ,  C07K2319/00 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/18022 ,  C12N2760/18034 ,  C12N2760/18511 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The present invention provides nanoparticles and compositions of various constructs that combine meta-stable viral proteins (e.g., RSV F protein) and self-assembling molecules (e.g., ferritin, HSPs) such that the pre-fusion conformational state of these key viral proteins is preserved (and locked) along with the protein self-assembling into a polyhedral shape, thereby creating nanoparticles that are effective vaccine agents. The invention also provides nanoparticles comprising a viral fusion protein, or fragment or variant thereof, and a self-assembling molecule, and immunogenic and vaccine compositions including the same.

Abstract translation: 本发明提供了组合元稳定病毒蛋白（例如RSV F蛋白）和自组装分子（例如铁蛋白，HSP）的各种构建体的纳米颗粒和组合物，使得这些关键病毒蛋白的融合前构象状态是 保存（和锁定）以及蛋白质自组装成多面体形状，从而产生作为有效疫苗剂的纳米颗粒。 本发明还提供包含病毒融合蛋白或其片段或变体和自组装分子的纳米颗粒，以及包含其的免疫原性和疫苗组合物。