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公开(公告)号：US20110184415A1
公开(公告)日：2011-07-28
申请号：US13013669
申请日：2011-01-25
IPC分类号： A61B17/80
CPC分类号： A61B17/7059 , A61B17/8047 , A61B17/8052
摘要： A bone stabilization system is provided having a plate with a top and bottom surface and a hole therethrough extending along a longitudinal axis. An annular groove in the top surface encircles the axis and defines outer facing sides of a plurality of spring members integral to the plate. A plurality of slots define sides of the spring members the inward facing side of the spring members form the upper portion of the hole, which includes a first spherical portion. A fastener with a spherical portion on the fastener head extends into the hole with the spring members urged apart to allow the head to pass but restraining removal until the resistance provide by the spring members is overcome.
摘要翻译： 提供骨稳定系统，其具有具有顶表面和底表面的平板和沿着纵向轴线延伸穿过的孔。 顶表面中的环形槽围绕轴线并且限定与板成一体的多个弹簧构件的面向外侧。 多个槽限定弹簧构件的侧面，弹簧构件的向内侧形成孔的上部，其包括第一球形部分。 在紧固件头部上具有球形部分的紧固件延伸到孔中，弹簧构件被推开以允许头部通过，但是限制去除，直到克服了由弹簧构件提供的阻力。
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公开(公告)号：US08425576B2
公开(公告)日：2013-04-23
申请号：US13013669
申请日：2011-01-25
申请人： Mark E. Anderson , Janette L. Munoz
发明人： Mark E. Anderson , Paul A. Munoz
IPC分类号： A61B17/80
CPC分类号： A61B17/7059 , A61B17/8047 , A61B17/8052
摘要： A bone stabilization system is provided having a plate with a top and bottom surface and a hole therethrough extending along a longitudinal axis. An annular groove in the top surface encircles the axis and defines outer facing sides of a plurality of spring members integral to the plate. A plurality of slots define sides of the spring members the inward facing side of the spring members form the upper portion of the hole, which includes a first spherical portion. A fastener with a spherical portion on the fastener head extends into the hole with the spring members urged apart to allow the head to pass but restraining removal until the resistance provide by the spring members is overcome.
摘要翻译： 提供骨稳定系统，其具有具有顶表面和底表面的平板和沿着纵向轴线延伸穿过的孔。 顶表面中的环形槽围绕轴线并且限定与板成一体的多个弹簧构件的面向外侧。 多个槽限定弹簧构件的侧面，弹簧构件的向内侧形成孔的上部，其包括第一球形部分。 在紧固件头部上具有球形部分的紧固件延伸到孔中，弹簧构件被推开以允许头部通过，但是限制去除，直到克服了由弹簧构件提供的阻力。
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公开(公告)号：US08136483B2
公开(公告)日：2012-03-20
申请号：US13165057
申请日：2011-06-21
IPC分类号： A01K29/00
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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4.发明申请Methods of Treating Pulmonary Diseases and Disorders by Modulating Calcium/Calmodulin Dependent Protein Kinase II Activity 有权通过调节钙/钙调素依赖性蛋白激酶II活性治疗肺疾病和疾病的方法公开(公告)号：US20110152172A1
公开(公告)日：2011-06-23
申请号：US12820802
申请日：2010-06-22
IPC分类号： A61K38/00 , A61K31/4045 , A61K31/4709 , A61K31/496 , A61K31/454 , A61P11/06
CPC分类号： A61K31/18 , A61K31/4045 , A61K31/454 , A61K31/4709 , A61K31/496
摘要： Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II (CaMKII) activity, either directly or indirectly, thereby treating or preventing the pulmonary disease or disorder in the subject.
摘要翻译： 公开了治疗或预防受试者的肺部疾病或病症的方法，所述方法包括直接或间接施用有效量的抑制钙调蛋白激酶II（CaMKII）活性的化合物，从而治疗或预防肺部疾病或病症 在主题。
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公开(公告)号：US06860235B2
公开(公告)日：2005-03-01
申请号：US10693661
申请日：2003-10-24
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. Deployment of the membrane is facilitated by tapering its wall thickness towards its tip. In addition to AI and embryo transplant, other applications for the pathway include therapeutic, diagnostic, or other procedures such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 通过使其壁厚朝其尖端逐渐变细来促进膜的部署。 除了AI和胚胎移植之外，该途径的其他应用包括治疗，诊断或其他手术，例如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：USD333992S
公开(公告)日：1993-03-16
申请号：US637760
申请日：1991-01-07
申请人： Mark E. Anderson
设计人： Mark E. Anderson
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7.发明授权Methods, systems, and tool assemblies for distributing weight between an earth-boring rotary drill bit and a reamer device 有权用于在钻孔旋转钻头和铰刀装置之间分配重量的方法，系统和工具组件公开(公告)号：US08584776B2
公开(公告)日：2013-11-19
申请号：US12696735
申请日：2010-01-29
IPC分类号： E21B10/26
摘要： Methods, systems, and tool assemblies for distributing weight between a bit and a reamer device are disclosed. For example, at least one of the drill bit and the reamer may be configured to selectively distribute a weight-on-bit between the drill bit and the reamer, such as within a predetermined range. Additionally, methods of drilling wellbores may include selectively distributing a weight-on-bit applied to a bottom hole assembly between a drill bit and a reamer of the bottom hole assembly. Also, a reamer may be configured to exhibit a first maximum rate-of-penetration into a relatively hard formation, and a drill bit may be configured to exhibit a second maximum rate-of-penetration into a relatively soft formation that is less than the first maximum rate-of-penetration.
摘要翻译： 公开了用于在钻头和铰刀装置之间分配重量的方法，系统和工具组件。 例如，钻头和铰刀中的至少一个可以被配置成选择性地在钻头和铰刀之间分配钻头上的重物，例如在预定范围内。 另外，钻井孔的方法可以包括选择性地分配施加到井底组件的钻头和底孔组件的铰刀之间的重量。 此外，铰刀可以被配置为展现出相对硬的地层的第一最大渗透速率，并且钻头可以被配置为展现出相对软的地层中的第二最大渗透率，该相对较软的地层小于 第一最大渗透率。
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8.发明授权Earth-boring tools and components thereof including blockage-resistant internal fluid passageways, and methods of forming such tools and components 有权钻孔工具及其部件，包括耐阻塞内部流体通道，以及形成这种工具和部件的方法公开(公告)号：US08240402B2
公开(公告)日：2012-08-14
申请号：US12570852
申请日：2009-09-30
IPC分类号： E21B10/18
CPC分类号： E21B10/602 , B22D19/14 , C22C1/1036 , C22C9/00
摘要： Earth-boring drill bits include a bit body including a blockage-resistant internal fluid passageway. The blockage-resistant internal fluid passageway includes at least one internal fluid passageway formed in the bit body and a cuttings filtering feature formed in the at least one internal fluid passageway configured to prevent at least some cuttings from flowing through the at least one internal fluid passageway. In one embodiment, the cuttings filtering feature includes at least one lateral member extending transversely across the at least one internal fluid passageway. In another embodiment, the cuttings filtering feature includes forming a central portion of the at least one internal fluid passageway with a width along a lateral axis thereof less than an average width of a fluid path extending through a nozzle disposed at least partially within the at least one internal fluid passageway. Methods of forming the blockage-resistant internal fluid passageway are also disclosed.
摘要翻译： 钻孔钻头包括具有阻塞内部流体通道的钻头体。 防堵塞的内部流体通道包括形成在钻头体中的至少一个内部流体通道和形成在至少一个内部流体通道中的切屑过滤特征，该内部流体通道构造成防止至少一些切屑流过至少一个内部流体通道 。 在一个实施例中，切屑过滤特征包括横向穿过至少一个内部流体通道延伸的至少一个横向构件。 在另一个实施例中，切屑过滤特征包括形成至少一个内部流体通道的中心部分，其宽度沿着其横向轴线小于延伸穿过喷嘴的平均宽度，喷嘴至少部分地至少设置在至少 一个内部流体通道。 还公开了形成耐阻塞内部流体通道的方法。
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9.发明授权Earth-boring tools having expandable members and methods of making and using such earth-boring tools 有权具有可扩展构件的钻孔工具以及制造和使用这种钻孔工具的方法公开(公告)号：US08230951B2
公开(公告)日：2012-07-31
申请号：US12570464
申请日：2009-09-30
申请人： Steven R. Radford , Khoi Q. Trinh , Li Li , Mark E. Anderson
发明人： Steven R. Radford , Khoi Q. Trinh , Li Li , Mark E. Anderson
IPC分类号： E21B10/32
CPC分类号： E21B10/322
摘要： An expandable apparatus for use in a borehole includes a tubular body having at least one opening extending between a longitudinal bore of the tubular body and an outer surface of the tubular body and at least one member positioned within the at least one opening of the tubular body. The at least one member is configured to move between a retracted position and an extended position. An actuation structure is positioned within the tubular body. The actuation structure is coupled to the at least one member and is configured to move the at least one member from the retracted position to the extended position responsive to a flow rate of drilling fluid passing through the longitudinal bore.
摘要翻译： 一种用于钻孔的可扩张装置包括管状主体，其具有至少一个开口，其在管状主体的纵向孔和管状体的外表面之间延伸，并且至少一个构件定位在管状体的至少一个开口内 。 所述至少一个构件构造成在缩回位置和延伸位置之间移动。 致动结构定位在管状体内。 所述致动结构联接到所述至少一个构件，并且构造成响应于穿过所述纵向孔的钻井液的流量，将所述至少一个构件从所述缩回位置移动到所述延伸位置。
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10.发明申请BACKUP CUTTING ELEMENTS ON NON-CONCENTRIC EARTH-BORING TOOLS AND RELATED METHODS 审中-公开非集中接地工具的备份切割元件及相关方法公开(公告)号：US20110100714A1
公开(公告)日：2011-05-05
申请号：US12608832
申请日：2009-10-29
摘要： An apparatus for engaging a subterranean borehole includes a bi-center bit having backup cutting elements thereon. The bi-center bit includes a pilot bit section and a reamer bit section adjacent to the pilot bit section. The pilot bit section includes at least one primary cutting element and at least one backup cutting element rotationally trailing and laterally offset from the at least one primary cutting element. Methods of drilling a subterranean borehole include engaging a first portion of a borehole with a reamer bit section of a drill bit and simultaneously engaging a second, opposing portion of the borehole with a pilot bit section adjacent to the reamer bit section.
摘要翻译： 用于接合地下钻孔的装置包括在其上具有备用切割元件的双中心钻头。 双中心位包括导频位部分和与引导位部分相邻的扩孔器位部分。 导向钻头部分包括至少一个主切割元件和至少一个备用切割元件，该至少一个备用切割元件与所述至少一个主切割元件旋转地后退和横向地偏移。 钻探地下钻孔的方法包括将钻孔的第一部分与钻头的铰刀钻头部分接合，并且同时将钻孔的第二相对部分与邻近铰刀钻头部分的导向钻头部分接合。
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