公开(公告)号：US20230357395A1

公开(公告)日：2023-11-09

申请号：US18048614

申请日：2022-10-21

申请人： Marengo Therapeutics, Inc.

发明人： Andreas Loew ,  Nidhi Malhotra ,  Madan Katragadda ,  Peter Marek ,  Gurkan Guntas ,  Sangeetha Palakurthi

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/85

CPC分类号： C07K16/2809 ,  A61P35/00 ,  C07K16/2803 ,  C12N15/85 ,  A61K39/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565

摘要： Multifunctional molecules that include i) an antigen binding domain that binds to a T cell receptor beta chain constant domain 1 or T cell receptor beta chain constant domain 2; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; (iv) a death receptor signal enhancer; and/or (v) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

公开(公告)号：US20230333112A1

公开(公告)日：2023-10-19

申请号：US18174246

申请日：2023-02-24

申请人： Marengo Therapeutics, Inc.

发明人： Andreas Loew ,  Madan Katragadda ,  Gurkan Guntas ,  Peter Marek ,  Sangeetha Palakurthi

IPC分类号： G01N33/574 ,  C07K16/28 ,  A61P35/00

CPC分类号： G01N33/57484 ,  C07K16/2809 ,  A61P35/00 ,  A61K2039/505

摘要： Antibody molecules that bind to TRBC1 or TRBC2 are disclosed. Additionally disclosed are methods of detecting TRBC1 or TRBC2, methods of evaluating a subject or a disorder, and kits using the aforesaid antibody molecules.