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公开(公告)号：US20090068232A1
公开(公告)日：2009-03-12
申请号：US12207750
申请日：2008-09-10
Applicant: Mahesh Kumar , Muhammad Ayub Khan
Inventor： Mahesh Kumar , Muhammad Ayub Khan
CPC classification number: C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12R1/35
Abstract: The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.
Abstract translation: 本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。 在某些实施方案中，相对于野生型M，减毒细菌可另外表现出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质的表达降低 胆汁败霉菌 还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。 提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的 在鸡中
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公开(公告)号：US20110189099A1
公开(公告)日：2011-08-04
申请号：US13071601
申请日：2011-03-25
Applicant: Mahesh Kumar , Muhammad Ayub Khan
Inventor： Mahesh Kumar , Muhammad Ayub Khan
IPC: A61K49/00 , C12Q1/02 , C12Q1/68 , G01N33/569
CPC classification number: C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12R1/35
Abstract: The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.
Abstract translation: 本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。 在某些实施方案中，相对于野生型M，减毒细菌可另外表现出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质的表达降低 胆汁败霉菌 还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。 提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的 在鸡中
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公开(公告)号：US20090068231A1
公开(公告)日：2009-03-12
申请号：US12207698
申请日：2008-09-10
Applicant: Mahesh Kumar , Muhammad Ayub Khan
Inventor： Mahesh Kumar , Muhammad Ayub Khan
CPC classification number: A61K39/0241 , A61K2039/522 , G01N33/56933 , G01N33/6803 , G01N2333/30
Abstract: The present invention provides live, attenuated Mycoplasma bacteria that exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type Mycoplasma bacterium of the same species. Also provided are vaccines and vaccination methods involving the use of the live, attenuated Mycoplasma bacteria, and methods for making live attenuated Mycoplasma bacteria.
Abstract translation: 本发明提供了活的减毒支原体细菌，相对于野生型，表现出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质的表达 相同物种的支原体细菌 还提供了涉及使用活的，减毒的支原体细菌的疫苗和疫苗接种方法，以及用于制造活的减毒支原体细菌的方法。
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公开(公告)号：US08298552B2
公开(公告)日：2012-10-30
申请号：US13071601
申请日：2011-03-25
Applicant: Mahesh Kumar , Muhammad Ayub Khan
Inventor： Mahesh Kumar , Muhammad Ayub Khan
IPC: A61K39/02
CPC classification number: C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12R1/35
Abstract: The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.
Abstract translation: 本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。 在某些实施方案中，相对于野生型M，减毒细菌可另外显示出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质的表达降低 胆汁败霉菌 还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。 提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的 在鸡中
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公开(公告)号：US07935356B2
公开(公告)日：2011-05-03
申请号：US12207750
申请日：2008-09-10
Applicant: Mahesh Kumar , Muhammad Ayub Khan
Inventor： Mahesh Kumar , Muhammad Ayub Khan
IPC: A61K39/02
CPC classification number: C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12R1/35
Abstract: The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.
Abstract translation: 本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。 在某些实施方案中，相对于野生型M，减毒细菌可另外表现出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质的表达降低 胆汁败霉菌 还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。 提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的 在鸡中
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Patent Agency Ranking
公开(公告)号：US20080193480A1
公开(公告)日：2008-08-14
申请号：US11811222
申请日：2007-06-08
Applicant: Jeffrey Harold Rodenberg , Mahesh Kumar , Kalen Cookson
Inventor： Jeffrey Harold Rodenberg , Mahesh Kumar , Kalen Cookson
CPC classification number: C07K14/005 , A61K39/12 , A61K39/15 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2720/10022 , C12N2720/10034 , C12N2720/12022 , C12N2720/12034
Abstract: Antigenic isolates and vaccines for Infectious Bursal Disease Virus include variants of the molecular Group 6 family of IBDV isolates, in particular the 28-1 isolate.
Abstract translation: 用于传染性法氏囊病病毒的抗原分离物和疫苗包括IBDV分离株的分子6族家族的变体，特别是28-1分离株。
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公开(公告)号：US07357935B2
公开(公告)日：2008-04-15
申请号：US10837793
申请日：2004-05-03
Applicant: Henry H. Fan , Mahesh Kumar , Roberto Marcello La Ragione , Martin John Woodward
Inventor： Henry H. Fan , Mahesh Kumar , Roberto Marcello La Ragione , Martin John Woodward
IPC: A61K39/108
CPC classification number: A61K39/0258 , A61K2039/522 , A61K2039/55 , A61K2039/552 , Y02A50/474
Abstract: A genetic deletion mutant live E. coli vaccine suitable for mass application to poultry, including chickens, is provided. Also provided is a safe and effective method to protect poultry against the ravages of Escherichia coli bacillosis infection and disease in which a live mutant aroA-gene deleted E. coli immunogen is administered to chickens, turkeys and the like via mass application routes such as coarse sprays and drinking water.
Abstract translation: 提供了适合大规模应用于家禽，包括鸡的遗传缺失突变型活大肠杆菌疫苗。 还提供了一种安全有效的方法来保护家禽免受大肠杆菌杆菌感染和其中通过大量施用途径（例如粗大的）向鸡，火鸡等施用活的突变体aroA基因缺失的大肠杆菌免疫原的疾病的疾病 喷水和饮用水。
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公开(公告)号：US07338661B2
公开(公告)日：2008-03-04
申请号：US11076713
申请日：2005-03-10
Applicant: Jeffrey Harold Rodenberg , Mahesh Kumar , Kalen Cookson
Inventor： Jeffrey Harold Rodenberg , Mahesh Kumar , Kalen Cookson
CPC classification number: C07K14/005 , A61K39/12 , A61K39/15 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2720/10022 , C12N2720/10034 , C12N2720/12022 , C12N2720/12034
Abstract: Antigenic isolates and vaccines for Infectious Bursal Disease Virus include variants of the molecular Group 6 family of IBDV isolates, in particular the 28-1 isolate.
Abstract translation: 用于传染性法氏囊病病毒的抗原分离物和疫苗包括IBDV分离株的分子6族家族的变体，特别是28-1分离株。
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9.发明授权Digitally controlled monolithic active phase shifter apparatus having a cascode configuration 失效具有共源共栅配置的数字控制单片有源移相器装置
公开(公告)号：US4994773A
公开(公告)日：1991-02-19
申请号：US257482
申请日：1988-10-13
Applicant: Tzu H. Chen , Mahesh Kumar
Inventor： Tzu H. Chen , Mahesh Kumar
IPC: H03H11/20
CPC classification number: H03H11/20
Abstract: A digitally controlled active phase shifter with vernier control consists of a 180 degree phase bit in series with a 90 degree bit and a digitally controlled active vector generator with vernier control. The digitally controlled active vector generator consists of an active power divider with digitally adjustable amplitude, a pair of phase delay networks with an active power combiner employing vernier control. The power divider consists of two sets of parallel pairs of FET's in cascode configuration with all input nodes connected together and all output nodes from the same set tied together. The FET at the output node of each pair is a common gate configuration with its gate RF grounded through a bypass capacitor. The gate bias voltage is applied to the common gate FET to switch it ON or OFF to thereby provide a set of desired signal amplitudes which can be obtained by selecting the gain of each of the cascode stages in each of the parallel pairs. Two output signals from the power divider are fed into a pair of phase delay networks to get 90 degree phase differences. The two 90 degree out of phase signals are then combined by an active power combiner which consists of two pairs of FET's in cascode configuration with their output nodes connected together. The combined signal while maintaining constant amplitude can have phase variations beteen 0-90 degrees according to the amplitude ratio of the two 90 degree out of phase signals. The gate bias voltage applied to the two common gate FET's of the power combiner can be varied continuously to give additional phase variations of the combined signal at the output.
Abstract translation: 具有游标控制的数字控制有源移相器由与90度位串联的180度相位位和具有游标控制的数字控制有源矢量发生器组成。 数字控制有源矢量发生器由具有数字可调振幅的有功功率分配器，一对具有采用游标控制的有功功率组合器的相位延迟网络组成。 功率分配器由共同体组态中的两组并联对的FET组成，所有输入节点连接在一起，并将来自同一组的所有输出节点捆绑在一起。 每对输出节点的FET是通过旁路电容接地的栅极RF的公共栅极配置。 栅极偏置电压施加到公共栅极FET以将其导通或截止，从而提供一组期望的信号幅度，其可以通过选择每个并联对中的每个共源共栅级的增益来获得。 来自功率分配器的两个输出信号被馈送到一对相位延迟网络中以获得90度的相位差。 然后，两个90度异相信号由有源功率组合器组合，该有功功率组合器由串联组合中的两对FET组成，其输出节点连接在一起。 保持恒定幅度的组合信号可以根据两个90度异相信号的振幅比具有0-90度的相位变化。 施加到功率组合器的两个公共栅极FET的栅极偏置电压可以连续变化，以在输出端产生组合信号的附加相位变化。
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公开(公告)号：US4897615A
公开(公告)日：1990-01-30
申请号：US278094
申请日：1988-11-30
Applicant: Tzu-Hung Chen , Mahesh Kumar
Inventor： Tzu-Hung Chen , Mahesh Kumar
IPC: H03F3/30
CPC classification number: H03F3/3076
Abstract: Amplifiers operating in push-pull are implemented to obviate input baluns and output signal combiners and their attendant losses. Amplifiers having two signal branches that each receive the input signal and have their signal branch outputs connected directly together. Each branch operates during alternate half cycles of the input signal while direct combining of the branch signal outputs produces a composite signal corresponding to the complete input signal. Each branch includes a matching input circuit and a heterojunction bipolar transistor whcih may be configured in either common collector or common emitter arrangement. The transistors are different since one is an NPN while the other is a PNP but they are selected to have similar direct current and radio frequency characteristics.
Abstract translation: 实现以推挽操作的放大器，以消除输入平衡 - 不平衡变换器和输出信号组合器及其伴随的损耗。 具有两个信号分支的放大器，每个信号分支接收输入信号并使其信号分支输出直接连接在一起。 每个分支在输入信号的交替半周期期间操作，而分支信号输出的直接组合产生对应于完整输入信号的复合信号。 每个分支包括匹配输入电路，并且异相结双极晶体管可以配置在公共集电极或共同发射极布置中。 晶体管是不同的，因为一个是NPN，而另一个是PNP，但它们被选择为具有类似的直流和射频特性。
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