公开(公告)号：US20210094991A1

公开(公告)日：2021-04-01

申请号：US15733619

申请日：2019-03-19

申请人： MULTIVIR INC.

发明人： Robert E. SOBOL ,  Kerstin B. MENANDER ,  Dora WIEDERHOLD ,  Sunil CHADA

IPC分类号： C07K14/47 ,  A61P35/00 ,  A61K35/768 ,  C07K14/54 ,  C12N15/86

摘要： Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one CD 122/CD 132 agonist, at least one immune checkpoint inhibitor and a viral composition comprising one or more viruses engineered to overexpress a tumor suppressor gene and/or an adenoviral death protein. Also provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one oncolytic viral composition and at least one CD122/CD132 agonist and at least one immune checkpoint inhibitor. Also provided herein are methods of enhancing anti-tumor efficacy by administering the agents described above in combination with other cancer therapies. In highly aggressive forms of cancer, known to be generally resistant to immune therapies, these treatments unexpectedly resulted in complete tumor remissions and curative outcomes.

公开(公告)号：US20220226402A1

公开(公告)日：2022-07-21

申请号：US17593486

申请日：2020-03-25

申请人： NORTHSHORE UNIVERSITY HEALTH SYSTEM ,  MULTIVIR INC.

发明人： Prem SETH ,  Sunil CHADA ,  Dora WIEDERHOLD ,  Kerstin B. MENANDER ,  Robert E. SOBOL

IPC分类号： A61K35/761 ,  C12N15/86 ,  A61K48/00 ,  C07K14/71 ,  A61P35/00 ,  A61P35/04 ,  A61K38/20 ,  A61K38/17 ,  A61K39/395

摘要： Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of an adenoviral vector with a genetically modified fiber incorporating a Lyp-1 peptide motif and at least one CD122/CD132 agonist and/or an immune checkpoint inhibitor.

公开(公告)号：US20200009203A1

公开(公告)日：2020-01-09

申请号：US16468408

申请日：2017-12-12

申请人： MULTIVIR INC.

发明人： Robert E. SOBOL ,  Kerstin B. MENANDER ,  Dora WIEDERHOLD ,  Sunil CHADA

IPC分类号： A61K35/761 ,  A61K39/395 ,  C12N7/00 ,  A61K38/19 ,  A61K38/22 ,  A61K38/44 ,  A61K38/16 ,  A61K35/763 ,  A61K31/513 ,  A61K31/7068 ,  A61P35/00 ,  A61K38/20 ,  A61K45/06 ,  A61K38/21

摘要： Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one immune checkpoint inhibitor and a viral composition comprising one or more viruses engineered to comprise an N1L gene deletion, a matrix-degrading protein gene, an adenoviral death protein (ADP) gene, and/or a cytochrome p450 gene. Also provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of a viral composition comprising two or more viruses engineered to comprise an N1L gene deletion a matrix-degrading protein gene, an adenoviral death protein (ADP) gene, and/or a cytochrome p450 gene. Also provided herein are methods of enhancing antitumor efficacy by administering the agents described above in combination with other cancer therapies.

公开(公告)号：US20240042061A1

公开(公告)日：2024-02-08

申请号：US18268752

申请日：2021-12-21

申请人： MULTIVIR INC.

发明人： Robert E. SOBOL ,  Kerstin B. MENANDER ,  Dora WIEDERHOLD ,  Sunil CHADA

IPC分类号： A61K48/00 ,  A61P11/00 ,  A61P35/00 ,  A61K45/06 ,  A61P31/20 ,  A61P31/14 ,  C12N15/86

CPC分类号： A61K48/0066 ,  A61P11/00 ,  A61P35/00 ,  A61K45/06 ,  A61P31/20 ,  A61P31/14 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2710/10088

摘要： Provided herein are methods and compositions for suppressing or preventing an infection in a subject infected by a pathogen or decreasing organ or tumor tissue fibrosis that involve administering to the subject a composition that includes a therapeutically effective amount of a p53 therapy. Also disclosed are methods of suppressing tumor stroma by contacting the tumor stroma with the p53 therapy, wherein the p53 suppresses tumor stroma activities.

公开(公告)号：US20190038713A1

公开(公告)日：2019-02-07

申请号：US15773609

申请日：2016-11-07

申请人： MULTIVIR INC.

发明人： Robert E. SOBOL ,  Kerstin B. MENANDER ,  Sunil CHADA

IPC分类号： A61K38/17 ,  A61K38/19 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  A61K35/763 ,  A61P35/00

摘要： Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one immune checkpoint inhibitor and a p53 and/or MDA-7 (IL24) gene therapy. Also provided herein are methods of enhancing anti-tumor efficacy by administering an extracellular matrix-degrading protein. Also provided herein are methods of enhancing anti-tumor efficacy by administering metronomic chemotherapy (for agents described above, 5FU+CTX+GM-CSF) in combination with a p53 and/or IL24 gene therapy.