- 专利标题： COMPOSITIONS COMPRISING TUMOR SUPPRESSOR GENE THERAPY AND IMMUNE CHECKPOINT BLOCKADE FOR THE TREATMENT OF CANCER
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申请号： US15773609申请日： 2016-11-07
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公开(公告)号： US20190038713A1公开(公告)日： 2019-02-07
- 发明人: Robert E. SOBOL , Kerstin B. MENANDER , Sunil CHADA
- 申请人： MULTIVIR INC.
- 申请人地址： US TX Houston
- 专利权人： MULTIVIR INC.
- 当前专利权人： MULTIVIR INC.
- 当前专利权人地址： US TX Houston
- 国际申请： PCT/US2016/060833 WO 20161107
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61K38/19 ; A61K39/395 ; C07K16/28 ; A61K45/06 ; A61K35/763 ; A61P35/00
摘要：
Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one immune checkpoint inhibitor and a p53 and/or MDA-7 (IL24) gene therapy. Also provided herein are methods of enhancing anti-tumor efficacy by administering an extracellular matrix-degrading protein. Also provided herein are methods of enhancing anti-tumor efficacy by administering metronomic chemotherapy (for agents described above, 5FU+CTX+GM-CSF) in combination with a p53 and/or IL24 gene therapy.
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