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    Microorganism for production of chemicals derived from acetyl-CoA
    2.
    发明授权
    Microorganism for production of chemicals derived from acetyl-CoA 有权

    公开(公告)号：US10294505B2

    公开(公告)日：2019-05-21

    申请号：US14428611

    申请日：2014-01-23

    申请人： Mitsui Chemicals, Inc.

    发明人： Anjali Madhavan ,  Ryota Fujii ,  Tomonori Hidesaki ,  Su Sun Chong

    IPC分类号： C12N9/00 ,  C12N9/88 ,  C12P1/04 ,  C12N15/52 ,  C12P13/14 ,  C12P19/32

    摘要： Disclosed is an acetyl-CoA-producing microorganism, which is obtained by imparting malate thiokinase and malyl-CoA lyase enzymatic activities to a microorganism having none of the following (a), (b), (c) or (d), without imparting any of (a), (b), (c) or (d), or, even when one or more of (a), (b), (c) or (d) are imparted, not allowing the functions thereof to be exerted: (a) a carbon dioxide fixation cycle having an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate, (b) a carbon dioxide fixation cycle having an enzymatic reaction from acetyl-CoA and CO2 to pyruvate, (c) a carbon dioxide fixation cycle having an enzymatic reaction from crotonyl-CoA and CO2 to ethylmalonyl-CoA or glutaconyl-CoA or (d) a carbon dioxide fixation cycle having an enzymatic reaction from CO2 to formate.

    MICROORGANISM FOR PRODUCTION OF CHEMICALS DERIVED FROM ACETYL-COA
    3.
    发明申请
    MICROORGANISM FOR PRODUCTION OF CHEMICALS DERIVED FROM ACETYL-COA 审中-公开
    用于生产从乙酰辅酶A衍生的化学物质的微生物

    公开(公告)号：US20150218607A1

    公开(公告)日：2015-08-06

    申请号：US14428611

    申请日：2014-01-23

    申请人： MITSUI CHEMICALS, INC.

    发明人： Anjali Madhavan ,  Ryota Fujii ,  Tomonori Hidesaki ,  Su Sun Chong

    IPC分类号： C12P19/32 ,  C12P13/14

    CPC分类号： C12P19/32 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P1/04 ,  C12P13/14 ,  C12Y401/03024 ,  C12Y602/01009

    摘要： Disclosed is an acetyl-CoA-producing microorganism, which is obtained by imparting malate thiokinase and malyl-CoA lyase enzymatic activities to a microorganism having none of the following (a), (b), (c) or (d), without imparting any of (a), (b), (c) or (d), or, even when one or more of (a), (b), (c) or (d) are imparted, not allowing the functions thereof to be exerted: (a) a carbon dioxide fixation cycle having an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate, (b) a carbon dioxide fixation cycle having an enzymatic reaction from acetyl-CoA and CO2 to pyruvate, (c) a carbon dioxide fixation cycle having an enzymatic reaction from crotonyl-CoA and CO2 to ethylmalonyl-CoA or glutaconyl-CoA or (d) a carbon dioxide fixation cycle having an enzymatic reaction from CO2 to formate.

    摘要翻译： 公开了通过赋予没有以下（a），（b），（c）或（d）所示的微生物的苹果酸硫激酶和丙烯酰辅酶A裂解酶酶活性而获得的乙酰辅酶A微生物，而不赋予 （a），（b），（c）或（d）中的任何一种，或者即使赋予（a），（b），（c）或（d）中的一种或多种， （a）具有从丙二酰辅酶A到丙二酸半醛或3-羟丙酸酯的酶反应的二氧化碳固定循环，（b）具有从乙酰辅酶A和CO 2到丙酮酸的酶反应的二氧化碳固定循环，（c ）具有从巴豆酰CoA和CO 2到乙基丙二酰CoA或戊烯酰辅酶A的酶反应的二氧化碳固定循环，或（d）具有从CO 2到甲酸盐的酶反应的二氧化碳固定循环。

    MICROORGANISM HAVING CARBON DIOXIDE FIXATION CYCLE INTRODUCED THEREINTO
    5.
    发明申请
    MICROORGANISM HAVING CARBON DIOXIDE FIXATION CYCLE INTRODUCED THEREINTO 有权
    具有二氧化碳固定循环的微生物介绍

    公开(公告)号：US20150232903A1

    公开(公告)日：2015-08-20

    申请号：US14428928

    申请日：2014-01-23

    申请人： MITSUI CHEMICALS, INC.

    发明人： Tomonori HIidesaki ,  Ryota Fujii ,  Yoshiko Matsumoto ,  Anjali Madhavan ,  Su Sun Chong

    IPC分类号： C12P19/32 ,  C12P7/28 ,  C12P7/62 ,  C12P7/48 ,  C12P7/46 ,  C12P7/04 ,  C12P13/14

    CPC分类号： C12P19/32 ,  C12N9/0006 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P1/04 ,  C12P7/04 ,  C12P7/28 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/48 ,  C12P7/625 ,  C12P13/14 ,  C12Y101/0106 ,  C12Y101/01081 ,  C12Y401/01047 ,  C12Y401/03024 ,  C12Y602/01009

    摘要： An acetyl-CoA producing microorganism obtained by imparting at least one enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism that does not have any of the following (a), (b), (c), (d) or (e): (a) a carbon dioxide fixation cycle including an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate; (b) a carbon dioxide fixation cycle including an enzymatic reaction from acetyl-CoA and CO2 to pyruvate; (c) a carbon dioxide fixation cycle including an enzymatic reaction from crotonyl-CoA and CO2 to ethylmalonyl-CoA or glutaconyl-CoA; (d) a carbon dioxide fixation cycle including an enzymatic reaction from CO2 to formate; or (e) at least one selected from the group consisting of malate thiokinase and malyl-CoA lyase.

    摘要翻译： 通过赋予至少一种选自苹果酸硫激酶，丙烯酰辅酶A裂解酶，乙醛酸溶血素酶，2-羟基-3-氧代丙酸盐还原酶和羟丙基还原酶的酶活性而获得的乙酰辅酶A生成微生物， 具有以下（a），（b），（c），（d）或（e）中任一项：（a）二氧化碳固定循环，其包括从丙二酰辅酶A到丙二酸二醛或3-羟基丙酸酯的酶反应; （b）二氧化碳固定循环，其包括从乙酰辅酶A和二氧化碳到丙酮酸的酶反应; （c）二氧化碳固定循环，其包括从巴豆酰辅酶A和二氧化碳到乙基丙二酰辅酶A或戊二酰辅酶A的酶反应; （d）二氧化碳固定循环，其包括从CO 2到甲酸的酶反应; 或（e）选自由苹果酸硫激酶和苹果酰CoA裂合酶组成的组中的至少一种。