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1.
公开(公告)号:US20240255492A1
公开(公告)日:2024-08-01
申请号:US18564642
申请日:2022-06-02
IPC分类号: G01N33/50 , C07K14/55 , C12N5/0783 , C12Q1/66 , G01N33/68
CPC分类号: G01N33/505 , C07K14/55 , C12N5/0636 , C12Q1/66 , G01N33/6869 , C12N2510/00 , G01N2333/55 , G01N2500/10
摘要: A functional cell-based potency assay for measuring the biological activity of IL-2 mutants with biased activity for the IL-2 receptor beta-gamma complex is described. In particular, the present invention relates to a Kit225 cell line that lacks expression of the IL-2 receptor alpha and its use in said functional cell-based potency assay.