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公开(公告)号：US11566057B2
公开(公告)日：2023-01-31
申请号：US16643881
申请日：2018-09-21
发明人： Anandan Palani , Qiaolin Deng , Chunhui Huang , Yuping Zhu , Elisabetta Bianchi , Federica Orvieto
摘要： Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
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公开(公告)号：US11492385B2
公开(公告)日：2022-11-08
申请号：US17003921
申请日：2020-08-26
发明人： Anandan Palani , Ravi Nargund , Paul E. Carrington , Tomi Sawyer , Qiaolin Deng , Antonello Pessi , Elisabetta Bianchi , Federica Orvieto
IPC分类号： A61K38/00 , A61K38/28 , A61P3/04 , A61P7/12 , A61P3/10 , C07K14/435 , C07K14/605
摘要： Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
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公开(公告)号：US10413593B2
公开(公告)日：2019-09-17
申请号：US15519565
申请日：2015-10-22
发明人： Elisabetta Bianchi , Paul E. Carrington , Qiaolin Deng , Ravi Nargund , Federica Orvieto , Anandan Palani , Antonello Pessi , Thomas Joseph Tucker , Chengwei Wu
IPC分类号： C07K14/605 , A61K38/26 , A61K38/28
摘要： Described are peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have relatively balanced agonist activity at the glucagon-like peptide 1 (GLP-1) receptor and the glucagon (GCG) receptor, and the use of such GLP-1 receptor/GCG receptor co-agonists for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
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公开(公告)号：US20170360893A1
公开(公告)日：2017-12-21
申请号：US15519565
申请日：2015-10-22
发明人： Elisabetta Bianchi , Paul E. Carrington , Qiaolin Deng , Ravi Nargund , Federica Orvieto , Anandan Palani , Antonello Pessi , Thomas Joseph Tucker , Chengwei Wu
IPC分类号： A61K38/28 , C07K14/605 , A61K38/26
CPC分类号： A61K38/28 , A61K38/26 , C07K14/605 , A61K2300/00
摘要： Described are peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have relatively balanced agonist activity at the glucagon-like peptide 1 (GLP-1) receptor and the glucagon (GCG) receptor, and the use of such GLP-1 receptor/GCG receptor co-agonists for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity
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公开(公告)号：US20160114000A1
公开(公告)日：2016-04-28
申请号：US14920012
申请日：2015-10-22
发明人： Elisabetta Bianchi , Paul E. Carrington , Qiaolin Deng , Ravi Nargund , Federica Orvieto , Anandan Palani , Antonello Pessi , Thomas Joseph Tucker , Chengwei Wu
IPC分类号： A61K38/26 , A61K38/28 , C07K14/605
CPC分类号： A61K38/28 , A61K38/26 , C07K14/605 , A61K2300/00
摘要： Described are peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have relatively balanced agonist activity at the glucagon-like peptide 1 (GLP-1) receptor and the glucagon (GCG) receptor, and the use of such GLP-1 receptor/GCG receptor co-agonists for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
摘要翻译： 描述了胰高血糖素的肽类似物，其已被修饰为对二肽基肽酶IV（DPP-IV）的切割和失活具有抗性，并增加肽类似物的体内半衰期，同时使肽类似物具有相对平衡的激动剂活性 胰高血糖素样肽1（GLP-1）受体和胰高血糖素（GCG）受体，以及使用这样的GLP-1受体/ GCG受体辅助激动剂来治疗代谢紊乱如糖尿病，非酒精性脂肪肝 疾病（NAFLD），非酒精性脂肪性肝炎（NASH）和肥胖症。
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公开(公告)号：US20190175744A1
公开(公告)日：2019-06-13
申请号：US16083201
申请日：2017-03-13
申请人： Anandan PALANI , Chunhui HUANG , Zhiqiang YANG , Lin YAN , Songnian LIN , Pei HUO , Qiaolin DENG , Elisabetta BIANCHI , Federica ORVIETO , Merck Sharp & Dohme Corp.
发明人： Anandan Palani , Chunhui Huang , Zhiqiang Yang , Lin Yan , Songnian Lin , Pei Huo , Qiaolin Deng , Elisabetta Bianchi , Federica Orvieto
摘要： Insulin-incretin conjugates comprising a peptide having agonist activity at the glucagon-like 1 (GLP-1) receptor, the glucagon (GCG) receptor, and/or the gastric inhibitory protein (GIP) receptor conjugated to an insulin molecule having agonist activity at the insulin receptor and use of the conjugates for treatment of metabolic diseases, for example, Type 2 diabetes, are described.
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公开(公告)号：US10800826B2
公开(公告)日：2020-10-13
申请号：US15765505
申请日：2016-10-04
发明人： Paul Carrington , Grigori Ermakov , Robert M. Garbaccio , Wolfgang Seghezzi , Elisabetta Bianchi , Federica Orvieto , Dennis Gately , Nick Knudsen , Anthony Manibusan
摘要： Described are antibody peptide conjugates (APCs) comprising an antibody conjugated to a peptide analog of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have agonist activity at the glucagon (GCG) receptor and the glucagon-like peptide 1 (GLP-1) receptor and the use of such APCs for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
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公开(公告)号：US10793615B2
公开(公告)日：2020-10-06
申请号：US15759911
申请日：2016-10-21
申请人： Merck Sharp & Dohme Corp. , Anandan Palani , Ravi Nargund , Paul E. Carrington , Tomi Sawyer , Qiaolin Deng , Antonello Pessi , Elisabetta Bianchi , Federica Orvieto
发明人： Anandan Palani , Ravi Nargund , Paul E. Carrington , Tomi Sawyer , Qiaolin Deng , Antonello Pessi , Elisabetta Bianchi , Federica Orvieto
IPC分类号： A61K38/00 , A61K38/28 , A61P3/04 , A61P7/12 , A61P3/10 , C07K14/435 , C07K14/605
摘要： Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
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公开(公告)号：US20200270325A1
公开(公告)日：2020-08-27
申请号：US16643881
申请日：2018-09-21
发明人： Anandan Palani , Qiaolin Deng , Chunhui Huang , Yuping Zhu , Elisabetta Bianchi , Federica Orvieto
IPC分类号： C07K14/605 , C07K14/62 , A61P3/10
摘要： Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
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公开(公告)号：US20190338008A1
公开(公告)日：2019-11-07
申请号：US15759911
申请日：2016-10-21
申请人： Anandan PALANI , Ravi NARGUND , Paul E. CARRINGTON , Tomi SAWYER , Qiaolin DENG , Antonello PESSI , Elisabetta BIANCHI , Fe-derica ORYIETO , Merck Sharp & Dohme Corp.
发明人： Anandan Palani , Ravi Nargund , Paul E. Carrington , Tomi Sawyer , Qiaolin Deng , Antonello Pessi , Elisabetta Bianchi , Federica Orvieto
IPC分类号： C07K14/605 , A61P3/04 , A61K38/28
摘要： Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
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