-
公开(公告)号：US10787441B2
公开(公告)日：2020-09-29
申请号：US16094621
申请日：2017-04-17
发明人： Joseph A. Kozlowski , Wensheng Yu , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Zhixin Lei
IPC分类号： A61K31/4178 , C07D405/14 , A61K38/21 , A61K38/19 , A61K45/06
摘要： A compound of Formula (I) or (II), for treating or preventing an HCV infection in a subject.
-
2.发明授权公开(公告)号：US10738062B2
公开(公告)日：2020-08-11
申请号：US16326043
申请日：2017-08-14
发明人： Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Coburn , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： C07D498/04 , A61K45/06 , A61K31/496 , A61K31/5365 , A61P31/14
摘要： The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
-
3.发明申请HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权杂环取代的四环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20150335648A1
公开(公告)日：2015-11-26
申请号：US14761256
申请日：2013-12-31
发明人： Wensheng Yu , Ling Tong , Joseph A. Kozlowski , Oleg Selyutin , Lei Chen , Jae-Hun Kim , Deyou Sha , Razia Rizvi , Bandarpalle Shankar , Bin Hu , Bin Zhong , Dahai Wang , Jinglai Hao , Wei Wei , Tao Ji , Shuai Zan
IPC分类号： A61K31/5365 , C07D498/04 , C07D513/04 , A61K45/06
CPC分类号： A61K31/5365 , A61K31/4985 , A61K31/7056 , A61K31/7072 , A61K45/06 , C07D498/04 , C07D513/04 , Y02A50/385 , Y02A50/389 , A61K2300/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的新型杂环取代的四环化合物：（I）及其药学上可接受的盐，其中A，A'，R 2 R3，R4和R如本文所定义。 本发明还涉及包含至少一种杂环取代的四环化合物的组合物，以及使用杂环取代的四环化合物治疗或预防患者HCV感染的方法。
-
公开(公告)号：US10246457B2
公开(公告)日：2019-04-02
申请号：US15564352
申请日：2016-04-04
发明人： Tony Siu , Michael D. Altman , Brian M. Andresen , Jian Liu , Joseph Kozlowski , Sobhana Babu Boga , Younong Yu , Rajan Anand , Jiaqiang Cai , Dahai Wang , Shilan Liu
IPC分类号： C07D471/04 , C07D401/14 , C07D405/14 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/14 , C07D409/14 , A61P19/02 , A61K45/06 , C07D231/56 , C07D413/14
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R7, R8 and R9 are as herein described. The present invention also provides pharmaceutical compositions comprising these compounds and methods for their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
-
公开(公告)号：US10214546B2
公开(公告)日：2019-02-26
申请号：US15538971
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC分类号： C07D519/00 , A61K45/06 , A61K31/4985 , A61P19/02
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
-
6.发明申请THIOPHENE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OFUSE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开噻吩取代的四环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20160257697A1
公开(公告)日：2016-09-08
申请号：US14761259
申请日：2013-12-31
发明人： Ling Tong , Wensheng Yu , Joseph A. Kozlowski , Lei Chen , Oleg Selyutin , Seong Heon Kim , Michael Dwyer , Bin Hu , Bin Zhong , Dahai Wang , Jinglai Hao , Changmao Shen , Zhixin Lei , Weijun Wang
IPC分类号： C07D498/04 , C07D519/00 , A61K45/06 , A61K31/7056 , A61K31/7072 , A61K38/00 , A61K31/5365 , A61K38/21
CPC分类号： C07D498/04 , A61K31/4985 , A61K31/5365 , A61K31/7056 , A61K31/7072 , A61K38/005 , A61K38/212 , A61K45/06 , C07D519/00 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： Thiophene-substituted tetracyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2, R3, R4 and R5 are as defined herein. The compositions comprising at least one thiophene-substituted tetracyclic compound, and methods of using the thiophene-substituted tetracyclic compounds for treating or preventing HCV infection in a patient are also provided.
摘要翻译： 式（I）的噻吩取代的四环化合物及其药学上可接受的盐，其中A，A'，R 2，R 3，R 4和R 5如本文所定义。 还提供了包含至少一种噻吩取代的四环化合物的组合物，以及使用噻吩取代的四环化合物治疗或预防患者HCV感染的方法。
-
公开(公告)号：US10646494B2
公开(公告)日：2020-05-12
申请号：US16326039
申请日：2017-08-14
发明人： Wensheng Yu , Ling Tong , Joseph A. Kozlowski , Craig A. Coburn , De-Yi Yang , Deyou Sha , Jae-Hun Kim , Michael Dwyer , Kartik M Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： C07D498/04 , A61K31/5365 , C07D519/00 , C07D513/04 , A61K45/06 , A61P31/12 , A61P31/22 , A61P31/14 , A61K31/4995
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
-
公开(公告)号：US20190127355A1
公开(公告)日：2019-05-02
申请号：US16094621
申请日：2017-04-17
发明人： Joseph A. Kozlowski , Wensheng Yu , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Zhixin Lei
IPC分类号： C07D405/14 , A61K31/4178 , A61K45/06
摘要： A compound of Formula (I) or (II), for treating or preventing an HCV infection in a subject.
-
公开(公告)号：US10087188B2
公开(公告)日：2018-10-02
申请号：US15538902
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Abdul-Basit Alhassan , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jyhshing Wang , Wensheng Yu , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/5377
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
-
![Substituted imidazo[1,5-a]pyrazines as Btk inhibitors](/abs-image/US/2018/08/07/US10040805B2/abs.jpg.150x150.jpg)
公开(公告)号：US10040805B2
公开(公告)日：2018-08-07
申请号：US15538957
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Xiaolei Gao , Deodial Guy Guiadeen , Shilan Liu , Dahai Wang
IPC分类号： A61K31/4985 , C07D487/04 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, Formula (I) or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.035 秒)
