Invention Grant
- Patent Title: Heterocycle-substituted tetracyclic compounds and methods of use thereof for the treatment of viral diseases
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Application No.: US16326039Application Date: 2017-08-14
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Publication No.: US10646494B2Publication Date: 2020-05-12
- Inventor: Wensheng Yu , Ling Tong , Joseph A. Kozlowski , Craig A. Coburn , De-Yi Yang , Deyou Sha , Jae-Hun Kim , Michael Dwyer , Kartik M Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Jeffrey P. Bergman; Catherine D. Fitch
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@12e822d6
- International Application: PCT/US2017/046676 WO 20170814
- International Announcement: WO2018/035005 WO 20180222
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61K31/5365 ; C07D519/00 ; C07D513/04 ; A61K45/06 ; A61P31/12 ; A61P31/22 ; A61P31/14 ; A61K31/4995
Abstract:
The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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