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公开(公告)号：US10736881B2
公开(公告)日：2020-08-11
申请号：US16221186
申请日：2018-12-14
申请人： MEI Pharma, Inc.
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： G01N33/50 , G01N33/68 , A61K31/444 , A61K31/454 , A61K31/496 , A61K31/506 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , A61K31/4184 , C07D401/06 , C07D401/12 , C07D403/02 , C07D409/04 , C07D413/02 , C07D403/06 , A61K31/4439 , A61K31/4709 , A61K31/5377
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
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公开(公告)号：US09402829B2
公开(公告)日：2016-08-02
申请号：US14627418
申请日：2015-02-20
申请人： MEI Pharma, Inc.
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/496 , A61K31/444 , A61K31/506 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D409/04 , C07D413/02 , G01N33/50 , G01N33/68 , C07D403/06 , A61K31/454 , A61K31/4709 , A61K31/5377
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
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公开(公告)号：US09024029B2
公开(公告)日：2015-05-05
申请号：US14016990
申请日：2013-09-03
申请人： MEI Pharma, Inc.
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： C07D211/32 , C07D403/02 , C07D235/00 , A61K31/445 , A61K31/415 , C07D235/18 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D409/04 , C07D413/02 , G01N33/50 , G01N33/68 , C07D403/06
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地说，本发明涉及含苯并咪唑的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病以及涉及组蛋白脱乙酰酶（HDAC）的调节异常或与其相关的其它疾病的药物。
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公开(公告)号：US20150157608A1
公开(公告)日：2015-06-11
申请号：US14627418
申请日：2015-02-20
申请人： MEI Pharma, Inc.
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/506 , A61K31/4439 , A61K31/496
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地说，本发明涉及含苯并咪唑的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病以及涉及组蛋白脱乙酰酶（HDAC）的调节异常或与其相关的其它疾病的药物。
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公开(公告)号：US09717713B2
公开(公告)日：2017-08-01
申请号：US15178742
申请日：2016-06-10
申请人： MEI Pharma, Inc.
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/496 , A61K31/444 , A61K31/506 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D409/04 , C07D413/02 , G01N33/50 , G01N33/68 , C07D403/06 , A61K31/454 , A61K31/4709 , A61K31/5377
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
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公开(公告)号：US20160279102A1
公开(公告)日：2016-09-29
申请号：US15178742
申请日：2016-06-10
申请人： MEI Pharma, Inc.
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/4709 , A61K31/4439 , A61K31/454
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
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公开(公告)号：US10201527B2
公开(公告)日：2019-02-12
申请号：US15612670
申请日：2017-06-02
申请人： MEI PHARMA, INC.
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： G01N33/50 , G01N33/68 , A61K31/444 , A61K31/454 , A61K31/496 , A61K31/506 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , A61K31/4184 , C07D401/06 , C07D401/12 , C07D403/02 , C07D409/04 , C07D413/02 , C07D403/06 , A61K31/4439 , A61K31/4709 , A61K31/5377
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
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