公开(公告)号：US09944639B2

公开(公告)日：2018-04-17

申请号：US15323565

申请日：2015-07-01

Applicant: Lupin Limited

Inventor： Manojkumar Ramprasad Shukla ,  Nirmal Kumar Jana ,  Sachin Jaysing Mahangare ,  Prashant Popatrao Vidhate ,  Dipak Raychand Lagad ,  Anand Jagannath Tarage ,  Sanjeev Anant Kulkarni ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D519/00 ,  A61K31/52 ,  A61K31/519 ,  C07D471/04 ,  C07D473/34 ,  C07D473/16 ,  C07D513/04

CPC classification number: C07D471/04 ,  C07D473/16 ,  C07D473/34 ,  C07D513/04 ,  C07D519/00

Abstract: Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R4, and n are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PI3K enzyme of a subject.

公开(公告)号：US09598391B2

公开(公告)日：2017-03-21

申请号：US14842141

申请日：2015-09-01

Applicant: LUPIN LIMITED

Inventor： Manojkumar Ramprasad Shukla ,  Ankush Gangaram Sarde ,  Rajeshkumar Maganlal Loriya ,  Vipul Dilip Pachpute ,  Navnath Bajirao Walke ,  Talha Hussain Khan ,  Sanjeev Anant Kulkarni ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D311/58 ,  C07D405/10 ,  A61K31/4025 ,  A61K31/353

CPC classification number: A61K31/352 ,  A61K31/353 ,  A61K31/4025 ,  C07D311/02 ,  C07D311/58 ,  C07D405/10

Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

公开(公告)号：US20230119316A1

公开(公告)日：2023-04-20

申请号：US17789293

申请日：2020-12-27

Applicant: Lupin Limited

Inventor： Sanjay Pralhad Kurhade ,  Prathap Sreedharan Nair ,  Sachin Sethi ,  Manojkumar Ramprasad Shukla ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj ,  Samiron Phukan ,  Pradeep Rangrao Patil ,  Sayyed Majid ,  Ramesh Phadatare ,  Navnath Walke ,  Vipul Pachpute ,  Balasaheb Gore ,  Vikas Tambe ,  Rohan Limaye ,  Avadhut Bhosale ,  Sachin Mahangare

IPC: C07D498/04 ,  A61K31/5383 ,  C07D491/052 ,  A61K31/519 ,  C07D487/04 ,  C07D471/04 ,  C07D487/10 ,  C07D491/20 ,  C07D498/20 ,  A61P35/00

Abstract: Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

公开(公告)号：US20230013778A1

公开(公告)日：2023-01-19

申请号：US17775679

申请日：2020-11-28

Applicant: LUPIN LIMITED

Inventor： Sachin Sethi ,  Prathap Sreedharan Nair ,  Manojkumar Ramprasad Shukla ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj ,  Samiron Phukan ,  Pradeep Rangrao Patil ,  Ganesh Kakade ,  Nilesh Raghunath Khedkar ,  Dagadu Dube ,  Vikas Sitaram Tambe ,  Sudhakar Maruti Balgude ,  Pradip Balu Wagh

IPC: C07D403/12 ,  C07D405/12 ,  C07D491/048 ,  A61P35/00

Abstract: Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

公开(公告)号：US09163001B2

公开(公告)日：2015-10-20

申请号：US14380632

申请日：2013-02-22

Applicant: LUPIN LIMITED

Inventor： Manojkumar Ramprasad Shukla ,  Ankush Gangaram Sarde ,  Rajeshkumar Maganlal Loriya ,  Vipul Dilip Pachpute ,  Navnath Bajirao Walke ,  Talha Hussain Khan ,  Sanjeev Anant Kulkarni ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D311/58 ,  A61K31/353 ,  C07D405/10 ,  A61K31/4025

CPC classification number: A61K31/352 ,  A61K31/353 ,  A61K31/4025 ,  C07D311/02 ,  C07D311/58 ,  C07D405/10

Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

Abstract translation: 本发明提供钙敏感受体调节剂（CaSR）。 特别地，本文所述的化合物可用于治疗，控制和/或减轻与钙感应受体（CaSR）调节相关的疾病，病症，综合征和/或病症的严重性。 本发明还在本文中提供其药物组合物，以及用于治疗，治疗和/或降低与调节CaSR相关的疾病，病症，综合征和/或病症的严重性的方法。 本发明还涉及制备本发明化合物的方法。

公开(公告)号：US09227919B2

公开(公告)日：2016-01-05

申请号：US14422373

申请日：2013-08-23

Applicant: Lupin Limited

Inventor： Manojkumar Ramprasad Shukla ,  Vinod Dinkar Chaudhari ,  Ankush Gangaram Sarde ,  Ramesh Dattatraya Phadtare ,  Mahadeo Bhaskar Tryambake ,  Dronamraju Prameela ,  Sanjeev Anant Kulkarni ,  Rajender Kumar Kamboj ,  Venkata P. Palle

IPC: C07D215/12 ,  C07C227/02 ,  C07C229/38 ,  A61K31/135 ,  A61K31/136 ,  A61K31/47 ,  C07C303/26

CPC classification number: C07C229/38 ,  C07C227/02 ,  C07C229/46 ,  C07C303/26 ,  C07C2102/10 ,  C07C2602/10 ,  C07D215/12

Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

Abstract translation: 本发明提供了作为钙敏感受体调节剂（CaSR）的芳基烷基胺化合物。 特别地，本文所述的化合物可用于治疗，控制和/或减轻与钙感应受体（CaSR）调节相关的疾病，病症，综合征和/或病症的严重性。 本发明还在本文中提供其药物组合物，以及用于治疗，治疗和/或降低与调节CaSR相关的疾病，病症，综合征和/或病症的严重性的方法。 本发明还涉及制备本发明化合物的方法。

公开(公告)号：US20150239827A1

公开(公告)日：2015-08-27

申请号：US14422373

申请日：2013-08-23

Applicant: Lupin Limited

Inventor： Manojkumar Ramprasad Shukla ,  Vinod Dinkar Chaudhari ,  Ankush Gangaram Sarde ,  Ramesh Dattatraya Phadtare ,  Mahadeo Bhaskar Tryambake ,  Dronamraju Prameela ,  Sanjeev Anant Kulkarni ,  Rajender Kumar Kamboj ,  Venkata P. Palle

IPC: C07C229/38 ,  C07D215/12 ,  C07C303/26 ,  C07C227/02

CPC classification number: C07C229/38 ,  C07C227/02 ,  C07C229/46 ,  C07C303/26 ,  C07C2102/10 ,  C07C2602/10 ,  C07D215/12

Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention. (Formula I)

Abstract translation: 本发明提供了作为钙敏感受体调节剂（CaSR）的芳基烷基胺化合物。 特别地，本文所述的化合物可用于治疗，控制和/或减轻与钙感应受体（CaSR）调节相关的疾病，病症，综合征和/或病症的严重性。 本发明还在本文中提供其药物组合物，以及用于治疗，治疗和/或降低与调节CaSR相关的疾病，病症，综合征和/或病症的严重性的方法。 本发明还涉及制备本发明化合物的方法。 （式I）

公开(公告)号：US20150038546A1

公开(公告)日：2015-02-05

申请号：US14380632

申请日：2013-02-22

Applicant: LUPIN LIMITED

Inventor： Manojkumar Ramprasad Shukla ,  Ankush Gangaram Sarde ,  Rajeshkumar Maganlal Loriya ,  Vipul Dilip Pachpute ,  Navnath Bajirao Walke ,  Talha Hussain Khan ,  Sanjeev Anant Kulkarni ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D311/58

CPC classification number: A61K31/352 ,  A61K31/353 ,  A61K31/4025 ,  C07D311/02 ,  C07D311/58 ,  C07D405/10

Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

公开(公告)号：US20170137421A1

公开(公告)日：2017-05-18

申请号：US15323565

申请日：2015-07-01

Applicant: Lupin Limited

Inventor： Manojkumar Ramprasad Shukla ,  Nirmal Kumar Jana ,  Sachin Jaysing Mahangare ,  Prashant Popatrao Vidhate ,  Dipak Raychand Lagad ,  Anand Jagannath Tarage ,  Sanjeev Anant Kulkarni ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D471/04 ,  C07D473/16 ,  C07D513/04 ,  C07D473/34

CPC classification number: C07D471/04 ,  C07D473/16 ,  C07D473/34 ,  C07D513/04 ,  C07D519/00

Abstract: Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R4, and n are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PI3K enzyme of a subject.

公开(公告)号：US20160075655A1

公开(公告)日：2016-03-17

申请号：US14952252

申请日：2015-11-25

Applicant: Lupin Limited

Inventor： Manojkumar Ramprasad Shukla ,  Vinod Dinkar Chaudhari ,  Ankush Gangaram Sarde ,  Ramesh Dattatraya Phadtare ,  Mahadeo Bhaskar Tryambake ,  Dronamraju Prameela ,  Sanjeev Kulkarni ,  Rajender Kumar Kamboj ,  Venkata P. Palle

IPC: C07D215/12 ,  C07C227/02 ,  C07C229/46 ,  C07C229/38

CPC classification number: C07C229/38 ,  C07C227/02 ,  C07C229/46 ,  C07C303/26 ,  C07C2102/10 ,  C07C2602/10 ,  C07D215/12

Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention. (Formula I)