公开(公告)号：US20150038546A1

公开(公告)日：2015-02-05

申请号：US14380632

申请日：2013-02-22

Applicant: LUPIN LIMITED

Inventor： Manojkumar Ramprasad Shukla ,  Ankush Gangaram Sarde ,  Rajeshkumar Maganlal Loriya ,  Vipul Dilip Pachpute ,  Navnath Bajirao Walke ,  Talha Hussain Khan ,  Sanjeev Anant Kulkarni ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D311/58

CPC classification number: A61K31/352 ,  A61K31/353 ,  A61K31/4025 ,  C07D311/02 ,  C07D311/58 ,  C07D405/10

Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

公开(公告)号：US09598391B2

公开(公告)日：2017-03-21

申请号：US14842141

申请日：2015-09-01

Applicant: LUPIN LIMITED

Inventor： Manojkumar Ramprasad Shukla ,  Ankush Gangaram Sarde ,  Rajeshkumar Maganlal Loriya ,  Vipul Dilip Pachpute ,  Navnath Bajirao Walke ,  Talha Hussain Khan ,  Sanjeev Anant Kulkarni ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D311/58 ,  C07D405/10 ,  A61K31/4025 ,  A61K31/353

CPC classification number: A61K31/352 ,  A61K31/353 ,  A61K31/4025 ,  C07D311/02 ,  C07D311/58 ,  C07D405/10

Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

公开(公告)号：US09163001B2

公开(公告)日：2015-10-20

申请号：US14380632

申请日：2013-02-22

Applicant: LUPIN LIMITED

Inventor： Manojkumar Ramprasad Shukla ,  Ankush Gangaram Sarde ,  Rajeshkumar Maganlal Loriya ,  Vipul Dilip Pachpute ,  Navnath Bajirao Walke ,  Talha Hussain Khan ,  Sanjeev Anant Kulkarni ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D311/58 ,  A61K31/353 ,  C07D405/10 ,  A61K31/4025

CPC classification number: A61K31/352 ,  A61K31/353 ,  A61K31/4025 ,  C07D311/02 ,  C07D311/58 ,  C07D405/10

Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

Abstract translation: 本发明提供钙敏感受体调节剂（CaSR）。 特别地，本文所述的化合物可用于治疗，控制和/或减轻与钙感应受体（CaSR）调节相关的疾病，病症，综合征和/或病症的严重性。 本发明还在本文中提供其药物组合物，以及用于治疗，治疗和/或降低与调节CaSR相关的疾病，病症，综合征和/或病症的严重性的方法。 本发明还涉及制备本发明化合物的方法。

公开(公告)号：US10239869B2

公开(公告)日：2019-03-26

申请号：US15757103

申请日：2016-09-03

Applicant: LUPIN LIMITED

Inventor： Vidya Ramdas ,  Rajeshkumar Maganlal Loriya ,  Moloy Banerjee ,  Pradeep Rangrao Patil ,  Advait Arun Joshi ,  Laxmikant Shamlal Datrange ,  Deepak Sahebrao Walke ,  Talha Hussain Khan ,  Amit Kumar Das ,  Ganesh Navinchandra Gote ,  Vaibhav Madhukar Kalhapure ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC: C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61P29/00

Abstract: The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention.