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1.发明授权公开(公告)号：US08003134B2
公开(公告)日：2011-08-23
申请号：US09990611
申请日：2001-11-21
IPC分类号： A61K33/30 , A61K31/34 , A61K31/70 , A61K31/145 , A61K31/195 , A61K31/315
CPC分类号： A61Q17/00 , A61K8/27 , A61K8/44 , A61K8/447 , A61K8/676 , A61K31/375 , A61K33/30 , A61K38/06 , A61Q19/004 , A61Q19/08 , Y10S514/886 , Y10S514/887 , A61K31/195 , A61K31/19 , A61K31/70 , A61K2300/00
摘要： An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid and may advantageously be formulated to have a pH above 3.5. Generally, the composition also includes non-toxic zinc salt, tyrosine compound, and/or pharmaceutically acceptable carrier. In addition, the composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. The topical composition may be in the form of a serum, a hydrophilic lotion, an ointment, a cream, or a gel.
摘要翻译： 公开了一种用于治疗老化或光损伤皮肤的抗坏血酸组合物和相关方法。 该组合物包括水和抗坏血酸，其至少一部分通常在相对高的温度和浓度条件下溶解预处理。 组合物通常包含至少约5.0％（w / v）抗坏血酸，并且可以有利地配制成具有高于3.5的pH。 通常，组合物还包括无毒的锌盐，酪氨酸化合物和/或药学上可接受的载体。 此外，组合物可以包括抗炎化合物，例如氨基糖和/或含硫抗炎化合物。 局部组合物可以是血清，亲水洗剂，软膏，奶油或凝胶的形式。
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公开(公告)号：US07816402B2
公开(公告)日：2010-10-19
申请号：US09997663
申请日：2001-11-29
IPC分类号： A61K31/375 , A61K31/7008
CPC分类号： A61K33/30 , A61K9/0014 , A61K31/198 , A61K31/375 , A61K31/70 , A61K31/7008 , A61K38/06 , A61K45/06 , A61K2300/00
摘要： An ascorbic acid-based composition and related method for the treatment of aging, photo-damaged or inflamed skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid formulated to have a pH above 3.5. 10 to 50% of the ascorbic acid is pretreated ascorbic acid. The composition may also include a non-toxic zinc salt, a tyrosine compound, and/or pharmaceutically acceptable carrier. The composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. Embodiments containing an aminosugar such as glucosamine are further useful for treating rosacea and other inflammatory skin ailments. The composition may be administered in a variety of forms suitable for topical application on skin.
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公开(公告)号：US07834055B2
公开(公告)日：2010-11-16
申请号：US12015258
申请日：2008-01-16
IPC分类号： A61K31/375 , A61K31/7008 , A61P17/00 , A61P17/10
CPC分类号： A61K33/30 , A61K9/0014 , A61K31/198 , A61K31/375 , A61K31/70 , A61K31/7008 , A61K38/06 , A61K45/06 , A61K2300/00
摘要： An ascorbic acid-based composition and related method for the treatment of aging, photo-damaged or inflamed skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid formulated to have a pH above 3.5. 10 to 50% of the ascorbic acid is pretreated ascorbic acid. The composition may also include a non-toxic zinc salt, a tyrosine compound, and/or pharmaceutically acceptable carrier. The composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. Embodiments containing an aminosugar such as glucosamine are further useful for treating rosacea and other inflammatory skin ailments. The composition may be administered in a variety of forms suitable for topical application on skin.
摘要翻译： 公开了一种用于治疗老化，光损伤或发炎皮肤的抗坏血酸组合物和相关方法。 该组合物包括水和抗坏血酸，其至少一部分通常在相对高的温度和浓度条件下溶解预处理。 组合物通常包含至少约5.0％（w / v）配制成pH高于3.5的抗坏血酸。 10〜50％的抗坏血酸被预处理抗坏血酸。 组合物还可以包括无毒的锌盐，酪氨酸化合物和/或药学上可接受的载体。 组合物可以包括抗炎化合物，例如氨基糖和/或含硫的抗炎化合物。 包含氨基糖如葡萄糖胺的实施方案进一步用于治疗酒渣鼻和其它炎性皮肤疾病。 组合物可以以适合于皮肤局部施用的各种形式施用。
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4.发明授权公开(公告)号：US06217914B1
公开(公告)日：2001-04-17
申请号：US09356142
申请日：1999-07-19
IPC分类号： A61K3119
CPC分类号： A61Q17/00 , A61K8/27 , A61K8/44 , A61K8/447 , A61K8/676 , A61K31/375 , A61K33/30 , A61K38/06 , A61Q19/004 , A61Q19/08 , Y10S514/886 , Y10S514/887 , A61K31/195 , A61K31/19 , A61K31/70 , A61K2300/00
摘要： An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid and may advantageously be formulated to have a pH above 3.5. Generally, the composition also includes non-toxic zinc salt, tyrosine compound, and/or pharmaceutically acceptable carrier. In addition, the composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. The topical composition may be in the form of a serum, a hydrophilic lotion, an ointment, a cream, or a gel.
摘要翻译： 公开了一种用于治疗老化或光损伤皮肤的抗坏血酸组合物和相关方法。 该组合物包括水和抗坏血酸，其至少一部分通常在相对高的温度和浓度条件下溶解预处理。 组合物通常包含至少约5.0％（w / v）抗坏血酸，并且可以有利地配制成具有高于3.5的pH。 通常，组合物还包括无毒的锌盐，酪氨酸化合物和/或药学上可接受的载体。 此外，组合物可以包括抗炎化合物，例如氨基糖和/或含硫抗炎化合物。 局部组合物可以是血清，亲水洗剂，软膏，奶油或凝胶的形式。
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5.发明授权Topical composition for the treatment of psoriasis and related skin disorders 有权用于治疗牛皮癣和相关皮肤病的局部组合物公开(公告)号：US07670620B2
公开(公告)日：2010-03-02
申请号：US10185388
申请日：2002-06-28
IPC分类号： A01N65/00 , A61K31/70 , A61K31/4375
CPC分类号： A61K45/06 , A61K31/4745 , A61K31/60 , A61K31/7008 , A61K36/63 , A61K36/87 , A61K38/2013 , A61K38/217 , Y10S514/855 , Y10S514/861 , Y10S514/863 , A61K2300/00
摘要： Compositions and methods of use thereof for the treatment of psoriasis and related skin ailments are disclosed. The compositions include topical skin formulations of glucosamine in an emollient base such as moisturizing cream. In addition to glucosamine, the formulations may include keratolytic substances such as coal tar extract or salicylic acid. The formulations may also include glucosamine and antioxidant anti-inflammatory herbal extracts such as oleuropein and berberine in an emollient base.
摘要翻译： 公开了用于治疗牛皮癣和相关皮肤疾病的组合物及其使用方法。 组合物包括在柔软剂基质如保湿霜中的葡糖胺的局部皮肤制剂。 除了葡糖胺之外，制剂可以包括角质分解物质，例如煤焦油提取物或水杨酸。 制剂还可以包括葡萄糖胺和抗氧化剂抗炎草药提取物，例如柔软剂基质中的橄榄精和小檗碱。
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公开(公告)号：US06440465B1
公开(公告)日：2002-08-27
申请号：US09562400
申请日：2000-05-01
IPC分类号： A61K3578
CPC分类号： A61K45/06 , A61K31/4745 , A61K31/60 , A61K31/7008 , A61K36/63 , A61K36/87 , A61K38/2013 , A61K38/217 , Y10S514/855 , Y10S514/861 , Y10S514/863 , A61K2300/00
摘要： Compositions and methods of use thereof for the treatment of psoriasis and related skin ailments are disclosed. The compositions include topical skin formulations of glucosamine in an emollient base such as moisturizing cream. In addition to glucosamine, the formulations may include keratolytic substances such as coal tar extract or salicylic acid. The formulations may also include glucosamine and antioxidant anti-inflammatory herbal extracts such as oleuropein and berberine in an emollient base.
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公开(公告)号：US20080125395A1
公开(公告)日：2008-05-29
申请号：US12015258
申请日：2008-01-16
CPC分类号： A61K33/30 , A61K9/0014 , A61K31/198 , A61K31/375 , A61K31/70 , A61K31/7008 , A61K38/06 , A61K45/06 , A61K2300/00
摘要： An ascorbic acid-based composition and related method for the treatment of aging, photo-damaged or inflamed skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid formulated to have a pH above 3.5. 10 to 50% of the ascorbic acid is pretreated ascorbic acid. The composition may also include a non-toxic zinc salt, a tyrosine compound, and/or pharmaceutically acceptable carrier. The composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. Embodiments containing an aminosugar such as glucosamine are further useful for treating rosacea and other inflammatory skin ailments. The composition may be administered in a variety of forms suitable for topical application on skin.
摘要翻译： 公开了一种用于治疗老化，光损伤或发炎皮肤的抗坏血酸组合物和相关方法。 该组合物包括水和抗坏血酸，其至少一部分通常在相对高的温度和浓度条件下溶解预处理。 组合物通常包含至少约5.0％（w / v）配制成pH高于3.5的抗坏血酸。 10〜50％的抗坏血酸被预处理抗坏血酸。 组合物还可以包括无毒的锌盐，酪氨酸化合物和/或药学上可接受的载体。 组合物可以包括抗炎化合物，例如氨基糖和/或含硫的抗炎化合物。 包含氨基糖如葡萄糖胺的实施方案进一步用于治疗酒渣鼻和其它炎性皮肤疾病。 组合物可以以适合于皮肤局部施用的各种形式施用。
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公开(公告)号：US06444699B1
公开(公告)日：2002-09-03
申请号：US09732385
申请日：2000-12-07
IPC分类号： A61K3134
摘要： An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid and may advantageously be formulated to have a pH above 3.5. Generally, the composition also includes non-toxic zinc salt, tyrosine compound, and/or pharmaceutically acceptable carrier. In addition, the composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. The topical composition may be in the form of a serum, a hydrophilic lotion, an ointment, a cream, or a gel.
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