公开(公告)号：US09821047B2

公开(公告)日：2017-11-21

申请号：US14473322

申请日：2014-08-29

申请人： Longhorn Vaccines and Diagnostics, LLC

发明人： Gerald W. Fischer ,  Luke T. Daum ,  Clara Jebet Sei

IPC分类号： C07K16/00 ,  A61K39/04 ,  C07K16/12 ,  A61K39/40 ,  C07K14/35 ,  G01N33/50 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/04 ,  A61K39/12 ,  A61K39/40 ,  A61K2039/521 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/70 ,  C07K14/35 ,  C07K16/1289 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/31 ,  C12N2760/16134 ,  G01N33/5055

摘要： The invention is directed to compositions and methods for generating or enhancing the immune system of a patient against infection by a pathogen, and in particular MTB. Compositions of the invention contain one or more non-naturally occurring antigens that generate an effective cellular or humoral immune response to MTB and/or antibodies that are specifically reactive to mycolic acid or to the surface of MTB. The greater activity of the immune system generated by a vaccine of the invention involve an conjugation of peptides to increase in the generation of memory T cells that provide for a greater and/or longer lived or extended response to an MTB infection. Preferably a response involves an increased generation of antibodies that enhance immunity against MTB infection and promote an enhanced phagocytic response.

公开(公告)号：US20150064198A1

公开(公告)日：2015-03-05

申请号：US14473322

申请日：2014-08-29

申请人： Longhorn Vaccines and Diagnostics, LLC

发明人： Gerald W. Fischer ,  Luke T. Daum ,  Clara Jebet Sei

IPC分类号： A61K39/04 ,  G01N33/50 ,  C07K14/35 ,  C07K16/12 ,  A61K39/40

CPC分类号： A61K39/04 ,  A61K39/12 ,  A61K39/40 ,  A61K2039/521 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/70 ,  C07K14/35 ,  C07K16/1289 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/31 ,  C12N2760/16134 ,  G01N33/5055

摘要： The invention is directed to compositions and methods for generating or enhancing the immune system of a patient against infection by a pathogen, and in particular MTB. Compositions of the invention contain one or more non-naturally occurring antigens that generate an effective cellular or humoral immune response to MTB and/or antibodies that are specifically reactive to mycolic acid or to the surface of MTB. The greater activity of the immune system generated by a vaccine of the invention involve an conjugation of peptides to increase in the generation of memory T cells that provide for a greater and/or longer lived or extended response to an MTB infection. Preferably a response involves an increased generation of antibodies that enhance immunity against MTB infection and promote an enhanced phagocytic response.

摘要翻译： 本发明涉及用于产生或增强患者免受病原体感染，特别是MTB感染的免疫系统的组合物和方法。 本发明的组合物含有一种或多种非天然存在的抗原，其产生对MTB和/或抗体的有效细胞或体液免疫应答，所述MTB和/或抗体对霉酚酸或对MTB的表面具有特异性的反应性。 由本发明的疫苗产生的免疫系统的更大活性涉及肽的缀合，以增加记忆性T细胞的产生，其提供对MTB感染的更大和/或更长寿命或延长的应答。 优选地，响应涉及提高针对MTB感染的免疫力的抗体的增加的产生并且促进增强的吞噬反应。