公开(公告)号：US20220162531A1

公开(公告)日：2022-05-26

申请号：US17671353

申请日：2022-02-14

Applicant: Life Technologies Corporation ,  Life Technologies AS

Inventor： Lars Norderhaug ,  Angel Varela-Rohena ,  Nephi D. Jones

IPC: C12M1/26 ,  B03C1/30 ,  B03C1/01 ,  B03C1/28 ,  A61M1/36 ,  B01L3/00 ,  C12M3/00 ,  C12M1/00 ,  C12M1/12

Abstract: A magnetic particle separation system includes a magnetic field generating device having an upper surface with a receiving area formed thereon; and a magnetic field generating element disposed beneath the upper surface, the magnetic field generating element being configured to produce a magnetic field above the upper surface. A container assembly is disposed on the upper surface and includes: a flexible container having an outer wall with an interior surface that at least partially bounds an internal compartment, the outer wall having a front side and an opposing back side with the internal compartment disposed therebetween; a fluid inlet extending through the outer wall at the front side; a fluid outlet extending through the outer wall at the front side; and a first partition projecting into the internal compartment from the front side between the fluid inlet and the fluid outlet.

公开(公告)号：US12226561B2

公开(公告)日：2025-02-18

申请号：US17671353

申请日：2022-02-14

Applicant: Life Technologies Corporation ,  Life Technologies AS

Inventor： Lars Norderhaug ,  Angel Varela-Rohena ,  Nephi D. Jones

IPC: A61M1/36 ,  B01L3/00 ,  B03C1/01 ,  B03C1/28 ,  B03C1/30 ,  C07K16/28 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/00

Abstract: A magnetic particle separation system includes a magnetic field generating device having an upper surface with a receiving area formed thereon; and a magnetic field generating element disposed beneath the upper surface, the magnetic field generating element being configured to produce a magnetic field above the upper surface. A container assembly is disposed on the upper surface and includes: a flexible container having an outer wall with an interior surface that at least partially bounds an internal compartment, the outer wall having a front side and an opposing back side with the internal compartment disposed therebetween; a fluid inlet extending through the outer wall at the front side; a fluid outlet extending through the outer wall at the front side; and a first partition projecting into the internal compartment from the front side between the fluid inlet and the fluid outlet.

公开(公告)号：US11268056B2

公开(公告)日：2022-03-08

申请号：US16067495

申请日：2016-12-21

Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGICES AG

Inventor： Lars Norderhaugh ,  Angel Varela-Rohena ,  Nephi D. Jones

IPC: C12M1/26 ,  B03C1/30 ,  B03C1/01 ,  B03C1/28 ,  A61M1/36 ,  B01L3/00 ,  C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C07K16/28

Abstract: Methods of separating magnetic particles from a fluid include introducing a fluid mixture that includes a liquid media, a biological component, and magnetic particles into an internal compartment of a container through an inlet, allowing at least a portion of the mixture to travel around a partition formed within the internal compartment and then exit the internal compartment through an outlet on the opposite side of the partition, and applying a magnetic field to the mixture in the internal compartment so that the magnetic particles are retained within the container or internal compartment thereof by the magnetic field. The partition is formed by permanently or reversibly securing upper and lower container walls together, such as by welding or pressing, between the inlet and the outlet such that the media and biological component must flow around the partition and through the magnetic field to exit the internal compartment through the outlet.

公开(公告)号：US20190010435A1

公开(公告)日：2019-01-10

申请号：US16067495

申请日：2016-12-21

Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGICES AG

Inventor： Lars Norderhaugh ,  Angel Varela-Rohena ,  Nephi D. Jones

IPC: C12M1/26 ,  B03C1/30 ,  C12M1/00 ,  C12M3/00 ,  C12M1/12

Abstract: Methods of separating magnetic particles from a fluid include introducing a fluid mixture that includes a liquid media, a biological component, and magnetic particles into an internal compartment of a container through an inlet, allowing at least a portion of the mixture to travel around a partition formed within the internal compartment and then exit the internal compartment through an outlet on the opposite side of the partition, and applying a magnetic field to the mixture in the internal compartment so that the magnetic particles are retained within the container or internal compartment thereof by the magnetic field. The partition is formed by permanently or reversibly securing upper and lower container walls together, such as by welding or pressing, between the inlet and the outlet such that the media and biological component must flow around the partition and through the magnetic field to exit the internal compartment through the outlet.