公开(公告)号：US07283877B1

公开(公告)日：2007-10-16

申请号：US10741409

申请日：2003-12-19

申请人： Leonid M Litvak ,  Edward H Overstreet

发明人： Leonid M Litvak ,  Edward H Overstreet

IPC分类号： A61N1/00

CPC分类号： A61B5/04001 ,  A61N1/36071

摘要： A new method of recording and processing neural responses (“NR”) is provided, wherein the method does not assume a linear system response and does not assume a linear response at the interface between electrodes and tissue. The method of the present invention cancels out non-linearities and/or system hysteresis. Other artifacts such as system cross-talk between stimulation and recording circuits are also canceled out. The method provided uses at least two stimulating electrodes simultaneously in one recording step.

摘要翻译： 提供了一种记录和处理神经反应（“NR”）的新方法，其中该方法不呈现线性系统响应，并且在电极和组织之间的界面处不呈现线性响应。 本发明的方法消除非线性和/或系统滞后。 诸如刺激和记录电路之间的系统串扰的其他伪影也被抵消。 所提供的方法在一个记录步骤中同时使用至少两个刺激电极。

公开(公告)号：US07805198B2

公开(公告)日：2010-09-28

申请号：US11830846

申请日：2007-07-31

申请人： Edward H Overstreet ,  Leonid M Litvak ,  William Vanbrooks Harrison

发明人： Edward H Overstreet ,  Leonid M Litvak ,  William Vanbrooks Harrison

IPC分类号： A61N1/00

CPC分类号： A61N1/36036

摘要： Errors in pitch (frequency) allocation within a cochlear implant are corrected in order to provide a significant and profound improvement in the quality of sound perceived by the cochlear implant user. In one embodiment, the user is stimulated with a reference signal, e.g., the tone “A” (440 Hz) and then the user is stimulated with a probe signal, separated from the reference signal by an octave, e.g., high “A” (880 Hz). The user adjusts the location where the probe signal is applied, using current steering, until the pitch of the probe signal, as perceived by the user, matches the pitch of the reference signal, as perceived by the user. In this manner, the user maps frequencies to stimulation locations in order to tune his or her implant system to his or her unique cochlea.

摘要翻译： 修正耳蜗植入物内的间距（频率）分配的误差，以便对由人工耳蜗植入物使用者感知到的声音的质量提供显着和深刻的改善。 在一个实施例中，用参考信号（例如，音调“A”（440Hz））刺激用户，然后用探测信号刺激用户，该探测信号与参考信号分开八度，例如高“A” （880Hz）。 用户使用当前转向来调整应用探测信号的位置，直到由用户感知到的探测信号的音高与用户感知到的参考信号的音调相匹配。 以这种方式，用户将频率映射到刺激位置，以便将他或她的植入系统调整到他或她的独特的耳蜗。

公开(公告)号：US07616999B2

公开(公告)日：2009-11-10

申请号：US11697605

申请日：2007-04-06

申请人： Edward H Overstreet ,  Leonid M Litvak ,  Michael A Faltys

发明人： Edward H Overstreet ,  Leonid M Litvak ,  Michael A Faltys

IPC分类号： A61N1/18

CPC分类号： A61N1/37241 ,  A61N1/0541 ,  A61N1/36036 ,  A61N1/37247

摘要： A multichannel cochlear implant system spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.

摘要翻译： 多通道人工耳蜗植入系统通过以下方式之一空间扩展靶神经组织中的激发图案：（1）对一小组电极的快速连续刺激，或（2）同时刺激一小组电极。 这种多电极刺激以同步方式刺激更多数量的神经元，从而增加细胞外电压波动的幅度并促进其记录。 电刺激同时（或以快速顺序）施加在选定的小组电极上，同时监测附近电极上的诱发化合物动作电位（ECAP）。 可观察到的ECAP的存在不仅在患者无意识或不能提供主观反馈的时候验证植入装置的操作，而且还提供了将所观察到的ECAP的大小记录为作为 施加的刺激的幅度。 从该数据可以获得安全，有效和舒适的阈值水平，其可以随后用作神经刺激装置的刺激参数的初始设置，或者指导神经刺激装置的刺激参数的设置。

公开(公告)号：US07251530B1

公开(公告)日：2007-07-31

申请号：US10731050

申请日：2003-12-09

申请人： Edward H Overstreet ,  Leonid M Litvak ,  William Vanbrooks Harrison

发明人： Edward H Overstreet ,  Leonid M Litvak ,  William Vanbrooks Harrison

IPC分类号： A61N1/00 ,  A61B5/12

CPC分类号： A61N1/36036

摘要： Errors in pitch (frequency) allocation within a cochlear implant are corrected in order to provide a significant and profound improvement in the quality of sound perceived by the cochlear implant user. In one embodiment, the user is stimulated with a reference signal, e.g., the tone “A” (440 Hz) and then the user is stimulated with a probe signal, separated from the reference signal by an octave, e.g., high “A” (880 Hz). The user adjusts the location where the probe signal is applied, using current steering, until the pitch of the probe signal, as perceived by the user, matches the pitch of the reference signal, as perceived by the user. In this manner, the user maps frequencies to stimulation locations in order to tune his or her implant system to his or her unique cochlea.

摘要翻译： 修正耳蜗植入物内的间距（频率）分配的误差，以便对由人工耳蜗植入物使用者感知到的声音的质量提供显着和深刻的改善。 在一个实施例中，用参考信号（例如，音调“A”（440Hz））刺激用户，然后用探测信号刺激用户，该探测信号与参考信号分开八度，例如高“A” （880Hz）。 用户使用当前转向来调整应用探测信号的位置，直到由用户感知到的探测信号的音高与用户感知到的参考信号的音调相匹配。 以这种方式，用户将频率映射到刺激位置，以便将他或她的植入系统调整到他或她的独特的耳蜗。

公开(公告)号：US07171261B1

公开(公告)日：2007-01-30

申请号：US10741410

申请日：2003-12-19

申请人： Leonid M Litvak ,  Edward H Overstreet

发明人： Leonid M Litvak ,  Edward H Overstreet

IPC分类号： A61B5/04

CPC分类号： A61B5/04001 ,  A61B5/4041

摘要： An improved forward-masking method of recording and processing neural responses (“NR”) is provided, wherein the method does not assume a linear system response and does not assume a linear response at the interface between electrodes and tissue. The method of the present invention cancels out non-linearities and/or system hysteresis. Other artifacts such as system cross-talk between stimulation and recording circuits are also canceled out.

摘要翻译： 提供了一种改进的记录和处理神经反应的前向掩蔽方法（“NR”），其中该方法不呈现线性系统响应，并且在电极和组织之间的界面处不呈现线性响应。 本发明的方法消除非线性和/或系统滞后。 诸如刺激和记录电路之间的系统串扰的其他伪影也被抵消。

公开(公告)号：US07574265B1

公开(公告)日：2009-08-11

申请号：US11428322

申请日：2006-06-30

申请人： Edward H Overstreet ,  Michael A Faltys

发明人： Edward H Overstreet ,  Michael A Faltys

IPC分类号： A61N1/36

CPC分类号： A61N1/36036 ,  A61N1/0541

摘要： A bionic ear cochlear stimulation system has the capability to stimulate fast enough to induce stochastic neural firing, thereby acting to restore “spontaneous” neural activity. Such neurostimulation involves the use of a high rate pulsitile stimulation signal that is amplitude modulated with sound information. Advantageously, by using such neurostimulation, a fitting system may be utilized that does not normally require T-level threshold measurements. T-level threshold measurements are not required in most instances because the high-rate pulsitile stimulation, even though at levels that would normally be a sub-threshold electrical stimulus, is able to modulate neural firing patterns in a perceptible way.

摘要翻译： 仿生耳蜗耳刺激系统具有刺激足够快以诱导随机神经发射的能力，从而起到恢复“自发”神经活动的作用。 这种神经刺激涉及使用用声音信息进行幅度调制的高速率脉动刺激信号。 有利地，通过使用这种神经刺激，可以采用通常不需要T级阈值测量的拟合系统。 在大多数情况下，不需要T级阈值测量，因为即使在通常为亚阈值电刺激的水平下，高速率脉动刺激能够以可察觉的方式调节神经发射模式。

公开(公告)号：US07636603B1

公开(公告)日：2009-12-22

申请号：US11428302

申请日：2006-06-30

申请人： Edward H Overstreet ,  Michael A Faltys

发明人： Edward H Overstreet ,  Michael A Faltys

IPC分类号： A61N1/36

CPC分类号： A61N1/36036 ,  A61N1/0541

摘要： A bionic ear cochlear stimulation system has the capability to stimulate fast enough to induce stochastic neural firing, thereby acting to restore “spontaneous” neural activity. Such neurostimulation involves the use of a high rate pulsitile stimulation signal that is amplitude modulated with sound information. Advantageously, by using such neurostimulation, a fitting system may be utilized that does not normally require T-level threshold measurements. T-level threshold measurements are not required in most instances because the high-rate pulsitile stimulation, even though at levels that would normally be a sub-threshold electrical stimulus, is able to modulate neural firing patterns in a perceptible way.

摘要翻译： 仿生耳蜗耳刺激系统具有刺激足够快以诱导随机神经发射的能力，从而起到恢复“自发”神经活动的作用。 这种神经刺激涉及使用用声音信息进行幅度调制的高速率脉动刺激信号。 有利地，通过使用这种神经刺激，可以采用通常不需要T级阈值测量的拟合系统。 在大多数情况下，不需要T级阈值测量，因为即使在通常为亚阈值电刺激的水平下，高速率脉动刺激能够以可察觉的方式调节神经发射模式。

公开(公告)号：US07317944B1

公开(公告)日：2008-01-08

申请号：US10886801

申请日：2004-07-08

申请人： Edward H Overstreet

发明人： Edward H Overstreet

IPC分类号： A61N1/08 ,  A61B5/00

CPC分类号： A61N1/36036 ,  A61N1/0541

摘要： A system and method for preserving temporal and spatial resolution in complex sounds for poor performing patients having high stimulation thresholds is described. The system and method employs two or more adjacent electrode contacts to deliver concurrent stimulation. This concurrent delivery of stimuli creates a high current field intensity that overlaps between individual current fields generated by the two or more adjacent electrodes and which individual fields are summed to create an overlapping field that has a higher current field intensity than a single current emanating from an individual electrode. The use of this method reduces or eliminates the need to increase either the stimulus current amplitude or to increase the pulse width, both of which may cause loss of system resolution, i.e., loss of fine structure information that is used to resolve complex sounds such as music.

摘要翻译： 描述了用于在具有高刺激阈值的不良表现的患者中保持复杂声音中的时间和空间分辨率的系统和方法。 该系统和方法采用两个或更多个相邻的电极触点来传送并发刺激。 这种并发传播的刺激产生了高电流场强度，其在由两个或更多个相邻电极产生的各个电流场之间重叠，并且将各个场相加以产生具有比单个电流发射的单个电流更高的电流场强度的重叠场 单个电极。 使用这种方法减少或消除了增加刺激电流幅度或增加脉冲宽度的需要，这两者都可能导致系统分辨率的损失，即用于解决复杂声音的精细结构信息的丢失，例如 音乐。

公开(公告)号：US07277759B2

公开(公告)日：2007-10-02

申请号：US10771819

申请日：2004-02-04

申请人： Edward H Overstreet ,  Guillermo A Calle ,  Kevin H Hood

发明人： Edward H Overstreet ,  Guillermo A Calle ,  Kevin H Hood

IPC分类号： A61N1/00

CPC分类号： A61N1/08 ,  A61B5/0488 ,  A61B5/4041

摘要： A method of recording neural responses reduces the inaccuracy of the recordings caused by nerve adaptation to repeated exposure of stimuli. In one embodiment, a maximum set of X number of successive stimuli are delivered through an electrode and the resulting neural response recorded and, afterwards, the next stimulation must occur through another electrode. This stimulation sequence prevents the same set of nerves from being stimulated too often, which can result in stimulus adaptation and cause measurement inaccuracy. In one embodiment of the invention, a smart software can be employed to provide visual plots of “growth curves”, including real-time calculated datapoints and their confidence intervals, and automatically terminate the recording session upon reaching a pre-set trigger. Alternatively, a human operator can terminate a recording session, based on visual feedback of growth curves, including their real-time calculated datapoints and confidence intervals.

摘要翻译： 记录神经反应的方法减少了神经适应对刺激反复暴露引起的记录的不准确性。 在一个实施例中，通过电极传送X个连续刺激的最大集合，并记录所得到的神经反应，然后，下一个刺激必须通过另一个电极发生。 该刺激序列防止相同的神经组被频繁地刺激，这可能导致刺激适应并导致测量不准确。 在本发明的一个实施例中，智能软件可用于提供“生长曲线”的视觉图，包括实时计算的数据点及其置信区间，并且在达到预置触发时自动终止记录会话。 或者，人类操作者可以基于生长曲线的视觉反馈（包括其实时计算的数据点和置信区间）来终止记录会话。

公开(公告)号：US07117038B1

公开(公告)日：2006-10-03

申请号：US10662615

申请日：2003-09-15

申请人： Edward H Overstreet

发明人： Edward H Overstreet

IPC分类号： A61B1/10

CPC分类号： A61N1/36036

摘要： A method and system for fitting a multichannel cochlear implant system to a patient increases the percentage of patients for which stapedial reflexes can be obtained, and increases the accuracy of predicting the “live speech” comfort levels of the patient's fitting programs from the stapedial reflex. Electrical stimuli are applied on multiple electrodes at “live speech” pulse rates. The neural excitation patterns elicited from such stimulation more closely resemble that which occurs when the system is subjected to normal speech patterns. By progressively setting threshold levels in bands, e.g., groups of electrodes, either overlapping or non-overlapping, as well as with a final check by globally adjusting the band obtained contour to the stapedial reflex, such values more closely resemble actual “live speech” program levels than those obtained with traditional methods. Further, broader excitation patterns produced by the activation of multiple electrodes increases the probability of obtaining reflex measurements where single electrode stimulation fails due to sparse neural survival.

摘要翻译： 用于将多声道人工耳蜗植入系统装配到患者的方法和系统增加了可以获得吻合反射的患者的百分比，并且增加了从吻合反射预测患者装配程序的“实况语音”舒适度的准确性。 电刺激以“实时语音”脉冲速率施加在多个电极上。 从这种刺激引起的神经激励模式更接近于当系统经受正常语音模式时发生的神经激励模式。 通过逐渐设置频带中的阈值水平，例如重叠或不重叠的电极组，以及通过将获得的频带全局调整为吻合反射的最终检查，这些值更接近实际的“实时语音” 程序水平高于传统方法。 此外，通过多个电极的激活产生的更广泛的激励模式增加了由于稀疏神经存活而获得单电极刺激失败的反射测量的可能性。