公开(公告)号：US20250157232A1

公开(公告)日：2025-05-15

申请号：US18508896

申请日：2023-11-14

Applicant: Leica Microsystems CMS GmbH

Inventor： Won Yung CHOI ,  Hung-Yu CHANG ,  Chi-Chou HUANG ,  Hoyin LAI ,  Sean McELROY ,  Luciano Andre GUERREIRO LUCAS

IPC: G06V20/69 ,  G06V10/82

Abstract: A first aspect of this disclosure is related to a computer-implemented method for identifying neuronal patterns in an image, comprising the steps: obtaining a first data set with Golgi-stained neuronal structures; based on the first data set, determining a first auxiliary data set, AR1, based on a first type of neuronal structure and a second auxiliary data set, AR2, based on a second type of neuronal structure; analyzing AR1 with a first method to identify information related to the first type of neuronal structure in AR1; analyzing AR2 with a second method to identify information related to the second type of neuronal structure in AR2; generating a second data set with the identified information related to the first and second type of neuronal structures.

公开(公告)号：US20250037485A1

公开(公告)日：2025-01-30

申请号：US18782178

申请日：2024-07-24

Applicant: Leica Microsystems CMS GmbH

Inventor： Constantin KAPPEL ,  José Miguel SERRA LLETI ,  Volker SCHWEIKHARD ,  Hoyin LAI

IPC: G06V20/69 ,  G06T7/12 ,  G06T7/50 ,  G06V20/70 ,  G16H30/40

Abstract: An image processing system is configured to receive at least one reference image, wherein each reference image is a microscopy image capturing cells of a biological sample, wherein the at least one reference image includes at least one reference labeling directed to a reference cellular compartment of the captured cells. The image processing system is configured to employ a trained deep neural network for processing the at least one reference image to generate a target image, wherein the target image includes a target labeling directed to a target cellular compartment of the captured cells, wherein the at least one reference labeling comprises a fluorescence labeling, wherein the reference cellular compartment is a distributed structure within cells, and wherein the target cellular compartment is the cell nucleus.