公开(公告)号：US20240016757A1

公开(公告)日：2024-01-18

申请号：US18365724

申请日：2023-08-04

申请人： LTS Lohmann Therapie-Systeme AG

发明人： Marco EMGENBROICH ,  Johannes Josef LEONHARD ,  Kristina KASSNER ,  Aurélia LAPPERT

IPC分类号： A61K9/70 ,  A61K47/34 ,  A61K47/02 ,  A61P21/00 ,  A61P25/20 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24 ,  A61K9/00 ,  A61K31/381

CPC分类号： A61K9/7069 ,  A61K47/34 ,  A61K9/7038 ,  A61K47/02 ,  A61P21/00 ,  A61P25/20 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24 ,  A61K9/0014 ,  A61K31/381

摘要： The present invention relates to aransdermal therapeutic system for the transdermal administration of a systemically active agent having a self-adhesive layer structure. The transdermal therapeutic system includes (A) a backing layer, and (B) a dried biphasic layer. The dried biphasic layer has (a) an outer phase having a composition comprising 75% to 100% of a polymer or polymer mixture, and (b) an inner phase having a composition that includes at least one active agent. The inner phase forms dispersed deposits in the outer phase, with the dried biphasic layer including (c) from 0.1% to 3.5% of an interface mediator other than silicone oil, with the interface mediator having with a kinematic viscosity of from 10 cSt to 100 000 cSt at 25° C.