公开(公告)号：US3666793A

公开(公告)日：1972-05-30

申请号：US3666793D

申请日：1969-04-22

Applicant: LONZA AG

Inventor： STOCKER AUGUST ,  BOOSEN KARL-JOSEF

IPC: C07C51/58 ,  C07C67/00

CPC classification number: C07C51/58 ,  C07C67/46 ,  C07C67/54 ,  C07C59/21 ,  C07C69/716

Abstract: Esters of gamma -chloroacetoacetic acid may be prepared by reacting diketene and chlorine in the presence of a low boiling organic solvent at temperatures of -10* to - 30* C. and esterifying the reaction product while maintaining the aforementioned temperatures. This process produces yields up to 87 percent of theoretical with product purity of 97 to 98 percent.

Abstract translation: γ-氯乙酰乙酸的酯可以通过在低沸点有机溶剂存在下，在-10℃至-30℃的温度下使双烯酮和氯反应并在保持上述温度的同时酯化反应产物来制备。 该方法产率高达理论值的87％，产品纯度为97％至98％。

公开(公告)号：US3655721A

公开(公告)日：1972-04-11

申请号：US3655721D

申请日：1969-05-07

Applicant: LONZA AG

Inventor： ARNI URS ,  FAUCCI ADRIANO ,  STOCKER AUGUST

IPC: C07C255/04 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C121/22

CPC classification number: C07C255/00

Abstract: MALONIC ACID DINITRILE IS PREPARED BY REACTING ACETONITRILE AND CYANOGEN CHLORIDE IN THE GASEOUS PHASE AT TEMPERATURES FROM 740 TO 780*C. TEMPERATURES FROM 750* TO 760*C. WITH MOLAR RATIOS OF 1:1 TO 1:5 OF CYANOGEN CHLORIDE TO ACETONITRILE ARE PREFERRED. THE CRUDE MIXTURE CONTAINING MALONIC ACID DINITRILE MAY BE PURIFIED BY CONVERSION OF THE PRINCIPAL IMPURITIES TO EASILY SEPARABLE COMPOUNDS BY A DIELS-ALDER OR SELECTIVE HYDROGENATION REACTION.

Abstract translation: 丙烯酸二腈通过乙腈和氯化氰在气相中在740℃至780℃的温度下反应制备。温度为750至760℃，摩尔比为1：1至1：5的氯化氰至乙腈 是优选的。 含有丙二酸二腈的粗混合物可以通过Diels-Alder或选择性氢化反应将主要杂质转化成容易分离的化合物来纯化。

公开(公告)号：US3683003A

公开(公告)日：1972-08-08

申请号：US3683003D

申请日：1970-03-20

Applicant: LONZA AG

Inventor： AUFDEREGGEN KLAUS ,  ARNI URS ,  FAUCCI ADRIANO ,  STOCKER AUGUST

IPC: D04B7/08 ,  D04B15/70 ,  C07C121/22 ,  C07C121/02

CPC classification number: C07C255/00 ,  D04B15/70

Abstract: Malonic acid dinitrile is prepared by reacting acetonitrile and cyanogen chloride in the gaseous phase at temperatures between 780* C. and 1,200* C. Yields exceeding 80 percent can be obtained and when the reactants flow through the reactor in a condition exceeding laminar flow and extending into turbulent flow, molar ratios of acetonitrile to cyanogen chloride of 4:1 and over are preferred with residence times at reaction temperatures of less than about 5 seconds.

Abstract translation: 丙烯酸二腈通过乙腈和氯化氰在气相中在780℃和1200℃之间的温度下反应来制备。可以获得超过80％的产率，并且当反应物在超过层流的条件下流过反应器并延伸 进入湍流，乙腈与氯化氰的摩尔比为4:1以上，优选在小于约5秒的反应温度下的停留时间。

公开(公告)号：US3657259A

公开(公告)日：1972-04-18

申请号：US3657259D

申请日：1969-10-28

Applicant: LONZA AG

Inventor： STOCKER AUGUST ,  PFAMMATTER THEODUL ,  SCHREINER GERHART ,  MARTI OTHMAR

IPC: C07D213/79 ,  C07D213/803 ,  C07D31/36

CPC classification number: C07D213/803 ,  Y02P20/582

Abstract: NICOTINIC ACID AND OTHER CARBOXLIC ACIDS HAVING A PYRIDINE NUCLEUS MAY BE PREPARED BY THE OXIDATION OF ALKYL PYRIDINE AND COMPOUNDS IN THE PRESENCE OF 25-600% EXCESS NITRIC ACID AT TEMPERATURES OF 180-370*C. WITH PRESSURES OF 20-500 ATM. THE NITRIC ACID CONCENTRATION OF THE REACTION MIXTURE IS ADJUSTED TO 10-28% TO PRECIPITATE AS CRYSTALLINE HYDRONITRATE AND SEPARATED FROM THE MIXTURE. THE PH OF AN AQUEOUS SOLUTION OF THE PYRIDINE CARBOXYLIC ACID HYDRONITRATE IS ADJUSTED WITH THE BASIC STARTING MATERIAL TO THE ISOELECTRIC POINT OF THE SPECIFIC PYRIDINE CARBOXYLIC ACID TO PRECEPITATE THE SAME. THE CRYSTALLINE PRECIPITATION IS SEPARATED AND THE MOTHER LIQUORS ARE COMBINED AND RECYCLED AS THE STARTING MATERIAL AFTER ADJUSTMENT OF THE CONCENTRATIONS THEREIN.