Scaffolds for uterine cell growth

    公开(公告)号:US10907132B2

    公开(公告)日:2021-02-02

    申请号:US15784917

    申请日:2017-10-16

    申请人: Lehigh University

    IPC分类号: C12N5/071 A61F2/00 A61B17/435

    摘要: A method for growing polarized endometrial cells, said method comprising: (a) disposing endometrial cells on a scaffold, said scaffold comprising a silica-based glass composition, characterized by multi-modal porosity, said scaffold being to define a top side and a bottom side; (b) providing nutrients to said top and bottom sides of said scaffold and an environment to grow polarized endometrial cells on said scaffold.

    Graded index single crystal active waveguide in glass

    公开(公告)号:US10345626B2

    公开(公告)日:2019-07-09

    申请号:US16190728

    申请日:2018-11-14

    申请人: Lehigh University

    摘要: In one aspect the invention provides a graded refractive index single crystal waveguide having a glass block containing at least one crystal core, the crystal core having a central portion extending along an axis from a first end to a second end; an interface defining a peripheral boundary of the crystal core at a junction of the crystal core and an adjacent portion of the glass block, and a continuous, radially symmetric misorientation transverse to the central portion; wherein the misorientation has a misorientation angle that increases with increasing distance from the central portion towards the interface.

    Methods of growing single crystals using solid-solid transformation of a glass

    公开(公告)号:US10294582B2

    公开(公告)日:2019-05-21

    申请号:US15272982

    申请日:2016-09-22

    申请人: LEHIGH UNIVERSITY

    摘要: The present invention includes methods of promoting single crystal growth via solid-solid transformation of an appropriate glass, while avoiding the gaseous or liquid phase. In certain embodiments, in the all-solid-state glass-to-crystal transformation of the invention, extraneous nucleation is avoided relative to crystal growth via spatially localized laser heating and optional inclusion of a suitable glass former in the composition. The ability to fabricate patterned single-crystal architecture on a glass surface was demonstrated, providing a new class of micro-structured substrate for low cost epitaxial growth and active planar devices, for example.