公开(公告)号：US09949940B2

公开(公告)日：2018-04-24

申请号：US14767424

申请日：2014-02-06

申请人： LABORATORIOS MENARINI SA

发明人： Reinhard Schmitz ,  Tobias Kohl

IPC分类号： A61K9/42 ,  A61K31/192 ,  A61K31/135 ,  A61K9/20 ,  A61K9/28 ,  A61K9/16 ,  A61K31/133 ,  A61K47/36

CPC分类号： A61K31/192 ,  A61K9/1682 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/284 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/133 ,  A61K31/135 ,  A61K47/36 ,  A61K2300/00

摘要： A pharmaceutical composition as a solid oral dosage form is described, comprising: i) a combination of two pharmacological active principles, dexketoprofen salt with an organic or inorganic base and tramadol salt with an organic or inorganic acid, wherein: the organic or inorganic base is selected in the group: trometamol, trimethylamine, dimethylamine, ethylamine, triethylamine, diethylamine, L-lysine, L-arginine, diethanolamine, sodium hydroxide, calcium hydroxide the organic or inorganic acid is selected in the group: hydrochloric, hydrobromic, phosphoric, sulfuric, methanesulfonic, benzenesulfonic, toluenesulfonic, acetic, propionic, malic, maleic, succinic, citric, L-tartaric, lactic, malonic, aspartic, glutamic; ii) microcrystalline cellulose as a filler; iii) a binder selected in the group: maize starch, pre-gelatinized maize starch, hypromellose or their mixtures; iv) pharmaceutically acceptable excipients.