公开(公告)号：US20210214434A1

公开(公告)日：2021-07-15

申请号：US16772244

申请日：2018-12-14

Applicant: LABORATOIRE FRANÇAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES

Inventor： Harry MEADE ,  Céline MONNET ,  Philippe MONDON

IPC: C07K16/28 ,  A61P19/02 ,  A61P37/06 ,  C07K16/04 ,  A61P7/00

Abstract: Disclosed is a variant of a parent polypeptide including an Fc fragment, the variant having an increased affinity for the FcRn receptor, and an increased affinity for at least one receptor of the Fc fragment (FcR) chosen from the FcγRI (CD64), FcγRIIIa (CD16a) and FcγRIIa (CD32a) receptors, relative to that of the parent polypeptide, characterised in that it includes: (i) the four mutations 334N, 352S, 378V and 397M; and (ii) at least one mutation chosen from 434Y, 434S, 226G, P228L, P228R, 230S, 230T, 230L, 241L, 264E, 307P, 315D, 330V, 362R, 389T and 389K; the numbering being that of the EU index or the Kabat equivalent.