公开(公告)号：US20210283055A1

公开(公告)日：2021-09-16

申请号：US17052412

申请日：2019-05-03

Applicant: L.E.A.F. HOLDINGS GROUP LLC

Inventor： Clet NIYIKIZA ,  Victor Mandla MOYO ,  Bolin GENG ,  Zhenghong XU ,  Kaniz KHALIFA ,  Gwangseong KIM

IPC: A61K9/127 ,  A61K31/202

Abstract: Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

公开(公告)号：US20220409565A1

公开(公告)日：2022-12-29

申请号：US17775422

申请日：2020-11-03

Applicant: L.E.A.F. HOLDINGS GROUP LLC

Inventor： Clet NIYIKIZA ,  Victor Mandla MOYO ,  Bolin GENT ,  Zhenghong XU ,  Kaniz KHALIFA ,  Gwangseong KIM

IPC: A61K31/202 ,  A61K33/06 ,  A61K47/69 ,  A61K9/127

Abstract: Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

公开(公告)号：US20210154140A1

公开(公告)日：2021-05-27

申请号：US17165534

申请日：2021-02-02

Applicant: L.E.A.F. HOLDINGS GROUP LLC

Inventor： Clet NIYIKIZA ,  Victor MOYO ,  Zhenghong XU ,  Kaniz KHALIFA

IPC: A61K9/127 ,  A61K45/06 ,  A61K47/68 ,  A61K47/69 ,  A61K33/243 ,  A61P31/18 ,  A61K31/337 ,  A61K31/555 ,  A61K31/4745 ,  A61P35/00 ,  A61K31/7068 ,  C07K16/28 ,  C07K16/30

Abstract: This disclosure relates to a targeted PEGylated liposomal gemcitabine (PLG) composition comprising a PEGylated liposome encapsulating one or more agents comprising gemcitabine and a targeting moiety; pharmaceutical composition and methods comprising PLG or producing PLG; and manufacturing equipment for performing the methods.

公开(公告)号：US20170319482A1

公开(公告)日：2017-11-09

申请号：US15587018

申请日：2017-05-04

Applicant: L.E.A.F. Holdings Group LLC

Inventor： Clet NIYIKIZA ,  Victor MOYO ,  Zhenghong XU ,  Kaniz KHALIFA

IPC: A61K9/127 ,  C07K16/30 ,  A61K31/7068 ,  C07K16/28

CPC classification number: A61K9/1271 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/555 ,  A61K31/7068 ,  A61K33/243 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6913 ,  A61P31/18 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/92 ,  A61K2300/00

Abstract: This disclosure relates to a targeted PEGylated liposomal gemcitabine (PLG) composition comprising a PEGylated liposome encapsulating one or more agents comprising gemcitabine and a targeting moiety; pharmaceutical composition and methods comprising PLG or producing PLG; and manufacturing equipment for performing the methods.