公开(公告)号：US20040002492A1

公开(公告)日：2004-01-01

申请号：US10373114

申请日：2003-02-24

申请人： Kudos Pharmaceuticals Ltd

发明人： Graeme Cameron Murray Smith ,  Niall Morrison Barr Martin ,  Stephen Philip Jackson ,  Mark James O'Connor ,  Alan Yin Kai Lau ,  Xiao-Ling Fan Cockcroft ,  Ian Timothy Williams Matthews ,  Keith Allan Menear ,  Laurent Jean Martin Rigoreau ,  Marc Geoffery Hummersone ,  Roger John Griffin

IPC分类号： A61K031/542 ,  A61K031/541 ,  A61K031/5377 ,  A61K031/4436 ,  A61K031/4433 ,  A61K031/382 ,  A61K031/381 ,  C07D417/02 ,  C07D413/02 ,  C07D49/02

CPC分类号： C07D409/04 ,  C07D417/04

摘要： The application concerns a compound of formula I: 1 wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3 group; Y is either O or S; R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; R3 is a phenyl or pyridyl group, attached by a first bridge group selected from nullSnull, nullS(nullO)null, nullS(nullO)2null, nullOnull, nullNRNnull and CRC1RC2null to an optionally substituted C5-20 carboaryl group, the phenyl or pyridyl group and optionally substituted C5-20 carboaryl group being optionally further linked by a second bridge group, so as to form an optionally substituted C5-7 ring, the phenyl or pyridyl group being further optionally substituted.

摘要翻译： 本申请涉及式I化合物：其中P和Q中的一个为O，P和Q中的另一个为CH，其中Q和P中的任一个为CH且具有R 1的碳原子之间为双键， 3>组 Y是O或S; R 1和R 2独立地是氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以一起形成任选取代的具有4至8个环的杂环 原子 R 3是苯基或吡啶基，其通过选自-S - ， - S（= O） - ， - S（= O）2 - ， - O - ， - NR N - 和任选取代的C 5-20碳芳基，苯基或吡啶基和任选取代的C 5-20碳芳基任选进一步通过第二桥基连接，从而形成任选取代的 C5-7环，苯基或吡啶基进一步任选被取代。