公开(公告)号：US20230091480A1

公开(公告)日：2023-03-23

申请号：US17931711

申请日：2022-09-13

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Jae-Byum JANG ,  Hyunwoo KIM ,  Young-Gyu YOON ,  Hoyeon NAM ,  Junyoung SEO

IPC: G01N21/64

Abstract: The present disclosure relates to a method and device for unmixing fluorescent signals based on a joint histogram. The method and device may be configured to obtain a plurality of images of a plurality of fluorescent materials marked in different biomolecules and to unmix the signals of the fluorescent materials based on at least one joint histogram index defined between the images of each of pairs each including two or more of the obtained images. According to the present disclosure, the joint histogram index may include at least one of Kullback-Leibler divergence, cross-entropy, or Rand-index.