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1.发明授权公开(公告)号：US10137276B2
公开(公告)日：2018-11-27
申请号：US14784782
申请日：2014-04-20
Inventor： Gary Nelson Garcia Molina , Giulio Tononi , Sander Theodoor Pastoor , Stefan Pfundtner , Brady Alexander Riedner , Michele Bellesi
Abstract: The present disclosure pertains to a system and method for managing a sleep session of a subject. Managing the sleep session is based on slow wave activity in the subject during the sleep session. Slow wave activity is related to sleep pressure. Sleep pressure dissipates and/or decreases as the subject sleeps. The dissipation dynamics depend on a given subject. The manner in which dissipation occurs regulates the length of the given sleep session and is linked to the temporal dynamics of slow wave activity. The system is configured to determine a metric indicating sleep pressure dissipation and, responsive to the determined sleep pressure dissipation metric indicating that sleep pressure dissipation has reached a dissipation threshold level during the sleep session, wake the subject.
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2.发明授权公开(公告)号：US11357950B2
公开(公告)日：2022-06-14
申请号：US16580845
申请日：2019-09-24
Inventor： Gary Nelson Garcia Molina , Tsvetomira Kirova Tsoneva , Brady Alexander Riedner , Giulio Tononi
Abstract: The present disclosure pertains to delivering sensory stimulation to a user during a sleep session. In some embodiments, sensors are configured to generate output signals conveying information related to brain activity of the user during the sleep session. Sensory stimulators are configured to provide the sensory stimulation to the user during the sleep session. One or more processors are configured to determine a demographic group for the user; select a stimulation parameter model associated with the demographic group of the user from a set of stimulation parameter models associated with different demographic groups; and control the one or more sensory stimulators to deliver the sensory stimulation to the user based on the stimulation parameter model for the demographic group of the user and the output signals.
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公开(公告)号：US10220183B2
公开(公告)日：2019-03-05
申请号：US14784746
申请日：2014-04-01
Inventor： Gary Nelson Garcia Molina , Michele Bellesi , Brady Alexander Riedner , Giulio Tononi
IPC: A61M21/02 , A61B5/00 , A61B5/0482 , A61M21/00
Abstract: A system is configured to provide sensory stimuli to a subject at a first intensity level, determine the effectiveness of the provided sensory stimuli, and incrementally increase the intensity level of the sensory stimuli based on the determined effectiveness. The effectiveness determination and the corresponding intensity increase are repeated one or more times during a given slow wave sleep episode. The system is configured to continue the effectiveness determinations and the corresponding intensity increases during the slow wave sleep episode until the intensity level reaches a maximum level, until an arousal level of the subject breaches an arousal level threshold, and/or until expiration of the period of slow wave sleep.
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Patent Agency Ranking
公开(公告)号：US10786174B2
公开(公告)日：2020-09-29
申请号：US15320795
申请日：2015-07-06
Inventor： Gary Nelson Garcia Molina , Michele Bellesi , Stefan Pfundtner , Brady Alexander Riedner , Giulio Tononi
IPC: A61B5/0484 , A61B5/00 , A61B5/048
Abstract: The present disclosure pertains to a system configured to adjust an intensity of sensory stimulation delivered to a subject during a sleep session based on sleep spindles in the subject during the sleep session. The system is configured to adjust the intensity of the stimulation based on a sleep spindle frequency and/or a sleep spindle density. The system is configured to determine a recent spindle density and/or a recent spindle frequency for a recent period of time during the sleep session based on detected sleep spindles, and to determine a previous spindle density and/or a previous spindle frequency for a previous period of time during the sleep session based on the detected sleep spindles. The system controls the intensity of sensory stimulation provided to the subject based on a comparison of the previous spindle density to the recent spindle density and/or the previous spindle frequency to the recent spindle frequency.
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公开(公告)号：US20180368755A1
公开(公告)日：2018-12-27
申请号：US16120935
申请日：2018-09-04
Applicant: Koninklijke Philips N.V.
Inventor： Gary Nelson Garcia Molina , Sander Theodoor Pastoor , Stefan Pfundtner , Brady Alexander Riedner , Michele Bellesi , Giulio Tononi
IPC: A61B5/00 , A61B5/0484 , G06F19/00 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/11 , A61B5/0496
Abstract: Systems and methods to detect sleep stages of a subject analyze physiological parameters of the subject in combination with a subject's reactions to stimuli of increasing intensity and/or stimuli having different modalities. Stimuli are provided until a predetermined level of probability is reached for the accuracy of an estimation of the sleep stage of the subject.
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公开(公告)号：US11052220B2
公开(公告)日：2021-07-06
申请号：US16307514
申请日：2017-06-26
Inventor： Gary Nelson Garcia Molina , Michele Bellesi , Brady Alexander Riedner , Giulio Tononi
Abstract: The present disclosure pertains to a system configured to adjust a volume of auditory stimulation delivered to a subject during sleep. The system is configured to determine a deepening time indicative of a rate at which sleep of the subject deepens during the sleep session. The deepening time is determined based on (i) a ratio of power in a high frequency band of an EEG signal to power in a low frequency band, (ii) a density of slow waves, or (iii) a hypnogram, indicative of sleep depth in the subject during the sleep session. The system is configured to determine a rate of volume increase for auditory stimulation during a subsequent sleep session based on the deepening time; and control the one or more sensory stimulators to adjust the volume of auditory stimulation provided to the subject during the subsequent sleep session based on the determined rate of volume increase.
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公开(公告)号：US10130788B2
公开(公告)日：2018-11-20
申请号：US15113104
申请日：2015-01-05
Inventor： Gary Nelson Garcia Molina , Michele Bellesi , Brady Alexander Riedner , Giulio Tononi , Juan Benzo
IPC: A61M21/02 , A61B5/00 , A61B5/0476 , A61M21/00
Abstract: The present disclosure pertains to a system configured to detect transitions in sleep state of a subject during a sleep session; provide sensory stimulation to the subject with a timing based on the detected transitions in sleep state; subsequent to the sleep session, obtain reference indications of transitions in sleep state; compare the detected transitions in sleep state to the reference indications of transitions in sleep state during the sleep session; based on the comparison, adjust baseline sleep state criteria to enhance correlation between detected transitions in sleep state during the sleep session using the baseline sleep state criteria and the reference indications of transitions in sleep state during the sleep session; and subsequent to adjustment of the baseline sleep state criteria, utilize the adjusted baseline sleep state criteria to detect transitions in sleep state of the subject for the purpose of controlling the one or more sensory stimulators.
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公开(公告)号：US10064578B2
公开(公告)日：2018-09-04
申请号：US14764063
申请日：2014-01-28
Inventor： Gary Nelson Garcia Molina , Sander Theodoor Pastoor , Stefan Pfundtner , Brady Alexander Riedner , Michele Bellesi , Giulio Tononi
IPC: A61B5/00 , A61B5/01 , A61B5/0484 , A61B5/0488 , A61B5/0496 , A61B5/08 , A61B5/11
Abstract: Systems and methods to detect sleep stages of a subject analyze physiological parameters of the subject in combination with a subject's reactions to stimuli of increasing intensity and/or stimuli having different modalities. Stimuli are provided until a predetermined level of probability is reached for the accuracy of an estimation of the sleep stage of the subject.
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