公开(公告)号：US20190070276A1

公开(公告)日：2019-03-07

申请号：US16122557

申请日：2018-09-05

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： A61K39/00 ,  C07K16/46 ,  C07K16/28 ,  C07K16/40

摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

公开(公告)号：US12076378B2

公开(公告)日：2024-09-03

申请号：US17366708

申请日：2021-07-02

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46

CPC分类号： A61K39/0011 ,  A61K39/001162 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/2803 ,  C07K16/40 ,  C07K16/468 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03

摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

公开(公告)号：US20220372170A1

公开(公告)日：2022-11-24

申请号：US17833149

申请日：2022-06-06

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： C07K16/40 ,  C07K14/705 ,  C07K14/57 ,  C07K16/28 ,  C07K16/18 ,  C12N5/0786 ,  A61K35/15 ,  C07K16/30

摘要： Modified macrophage immune cells are provided for treatment of cancer and other diseases. In particular said macrophages express chimeric antigen receptors (CAR). The single chain variable fragment (scFv) may be directed against thymidine kinase 1 (TK1) or hypoxanthine guanine phosphoribosyltransferase (HPRT). The signaling domain may be derived from a Toll-like receptor (TLR).

公开(公告)号：US20210330770A1

公开(公告)日：2021-10-28

申请号：US17366708

申请日：2021-07-02

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： A61K39/00 ,  C07K16/46 ,  C07K16/28 ,  C07K16/40 ,  C07K14/725 ,  A61P35/00

摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

公开(公告)号：US11052138B2

公开(公告)日：2021-07-06

申请号：US16122564

申请日：2018-09-05

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： A61K39/00 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46 ,  C07K14/725 ,  A61P35/00

摘要： A nucleic acid encoding a chimeric antigen receptor (CAR) comprising a single-chain variable fragment (scFv) operatively linked to a signaling domain that polarizes a macrophage to an M1 macrophage; wherein the nucleic acid is operatively linked to a macrophage specific promoter; and wherein the scFv is specific for a human antigen. Monocytes or macrophages comprising such a nucleic acid.

公开(公告)号：US10828355B2

公开(公告)日：2020-11-10

申请号：US16122563

申请日：2018-09-05

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： A47J31/18 ,  A61K39/00 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46 ,  C07K14/725 ,  A61P35/00

摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

公开(公告)号：US10821162B2

公开(公告)日：2020-11-03

申请号：US16122557

申请日：2018-09-05

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： A61K39/00 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46 ,  C07K14/725 ,  A61P35/00

摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

公开(公告)号：US20190070277A1

公开(公告)日：2019-03-07

申请号：US16122564

申请日：2018-09-05

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： A61K39/00 ,  C07K16/46 ,  C07K16/28 ,  C07K16/40

摘要： Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

公开(公告)号：US20170166657A1

公开(公告)日：2017-06-15

申请号：US15358395

申请日：2016-11-22

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： C07K16/40 ,  C07K14/57 ,  C07K16/30 ,  C07K16/18 ,  C12N5/0786 ,  A61K35/15 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K16/40 ,  A61K35/15 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/57 ,  C07K14/705 ,  C07K14/70503 ,  C07K16/18 ,  C07K16/2866 ,  C07K16/30 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/74 ,  C12N5/0645 ,  C12N2510/00 ,  C12Y204/02008 ,  C12Y207/01021

摘要： Modified macrophage immune cells are provided for treatment of cancer and other diseases.

公开(公告)号：US11352439B2

公开(公告)日：2022-06-07

申请号：US15358395

申请日：2016-11-22

申请人： Kim Leslie O'Neill ,  Scott Weber

发明人： Kim Leslie O'Neill ,  Scott Weber

IPC分类号： C07K16/40 ,  C07K14/705 ,  C07K14/57 ,  C07K16/28 ,  C07K16/18 ,  C12N5/0786 ,  A61K35/15 ,  C07K16/30 ,  A61K38/00 ,  A61K39/00

摘要： Modified macrophage immune cells are provided for treatment of cancer and other diseases.