公开(公告)号：US09713668B2

公开(公告)日：2017-07-25

申请号：US14369602

申请日：2013-01-04

申请人： Kenneth J Collier ,  Bryant J Pudil ,  Martin T Gerber

发明人： Kenneth J Collier ,  Bryant J Pudil ,  Martin T Gerber

IPC分类号： A61M1/34 ,  B01D63/00 ,  B01D61/14 ,  A61M1/16 ,  B01D15/08 ,  A61M1/14 ,  B01D61/28 ,  B01D63/04 ,  B01D63/08 ,  B01D61/24

CPC分类号： A61M1/3472 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1633 ,  A61M1/34 ,  A61M1/3475 ,  A61M1/3479 ,  A61M1/3482 ,  A61M1/3486 ,  A61M2205/75 ,  B01D15/08 ,  B01D61/145 ,  B01D61/243 ,  B01D61/28 ,  B01D63/00 ,  B01D63/043 ,  B01D63/08 ,  B01D2313/40 ,  B01D2317/02 ,  B01D2319/06

摘要： A device includes (i) a housing defining an interior, wherein the interior has a blood compartment, a plasma compartment, and a fluid compartment; (ii) a first filter disposed in the interior of the housing, and (iii) a second filter disposed in the interior of the housing. The first filter separates at least a portion of the blood compartment from at least a portion of the plasma compartment. The first filter is configured to allow plasma components, but not cell components, of blood to pass through the first filter from the blood compartment to the plasma compartment. The second filter separates at least a portion of the plasma compartment from at least a portion of the fluid compartment. The second filter is configured to allow fluid and small molecules, but not larger components, to pass through the second filter from the plasma compartment to the fluid compartment. The device may include a sorbent in the plasma compartment to remove or reduce the concentration of selected components of the plasma. In embodiments, a system including the device includes a sorbent with which the plasma may be contacted.