公开(公告)号：US4438093A

公开(公告)日：1984-03-20

申请号：US364182

申请日：1982-03-31

申请人： Kazuo Shimada ,  Masataka Akiyama ,  Masami Sudo

发明人： Kazuo Shimada ,  Masataka Akiyama ,  Masami Sudo

IPC分类号： A61K8/66 ,  A61K38/00 ,  A61Q11/00 ,  C12N9/24 ,  C12N9/46 ,  A61K7/28 ,  A61K37/48

CPC分类号： C12Y302/01058 ,  A61K8/66 ,  A61Q11/00 ,  C12N9/2454 ,  C12Y302/01011 ,  C12Y302/01059 ,  C12Y302/01084 ,  A61K38/00

摘要： An oral composition which comprises a pharmaceutically acceptable carrier, dextranase and .alpha.-1,3 glucanase, said dextranase being present in an enzyme unit ratio of 1:2 to 2:1 relative to said .alpha.-1,3 glucanase. The oral composition according to the present invention exhibits a synergistic effect of dextranase and .alpha.-1,3 glucanase and is highly effective for not only preventing but also suppressing various oral diseases such as dental caries, gingivitis and alveolar pyorrhea.

摘要翻译： 包含药学上可接受的载体，葡聚糖酶和α-1,3-葡聚糖酶的口服组合物，所述葡聚糖酶相对于所述α-1,3-葡聚糖酶以1：2至2：1的酶单位比存在。 根据本发明的口服组合物显示出葡聚糖酶和α-1,3葡聚糖酶的协同作用，并且对于不仅预防也抑制各种口腔疾病如龋齿，牙龈炎和肺泡脓肿是非常有效的。