公开(公告)号：US20170218001A1

公开(公告)日：2017-08-03

申请号：US15313049

申请日：2015-05-22

Applicant: University College Cork ,  Katholieke Universiteit Leuven

Inventor： Anita MAGUIRE ,  Alan Ford ,  Jan BALZARINI ,  Wim DEHAEN

IPC: C07F9/6561 ,  C07F9/6558 ,  C07F9/6512

CPC classification number: C07F9/65616 ,  C07F9/6512 ,  C07F9/65583

Abstract: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, and their use in medicine particular as anti-viral agents; wherein: X is selected from O and NR11; Y is selected from O, S and NR12; A is selected from —(CR1R2)n-, —(CR9R10)—, —(CR9R10)—(CR1R2)n-, —(CR1R3)—(CR2R4)—(CR1R2)n-, —CR3═CR4—(CR1R2)n- and —C≡C—(CR1R2)n-; R1 and R2 are independently selected from H, alkyl, hydroxyl, hydroxymethyl and halogen; R3 and R4 are independently selected from H and alkyl, or R3 and R4 together with the carbon atoms to which they are attached form a mono or bicyclic ring system selected from cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl and heteroaryl; R5 is selected from H, P(═O)(OH)2 and P(═O)(OH)—O—P(═O)(OH)2; R6 is selected from H and alkyl; R7 and R8 are independently selected from H, alkyl, halogen and hydroxymethyl R9 and R19 together with the carbon atoms to which they are attached form a mono or bicyclic ring system selected from cycloalkyl, cycloalkenyl, heterocycloalkyl and heterocycloalkenyl; R11 is selected from H and alkyl; R12 is selected from H and alkyl; m is 0, 1, 2 or 3; n is 1, 2 or 3; p is 0 or 1; q is 0, 1, 2 or 3; r is 0, 1, 2, 3, 4 or 5; s is 0 or 1; Base is a natural or non-natural nucleobase, and wherein each alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl and heteroaryl may be optionally substituted as described herein.

公开(公告)号：US20240293391A1

公开(公告)日：2024-09-05

申请号：US18567504

申请日：2022-06-24

Applicant: Katholieke Universiteit Leuven

Inventor： Wim DEHAEN ,  Steven DE JONGHE ,  Dominique SCHOLS ,  Tom VAN LOY

IPC: A61K31/4725 ,  A61K31/47 ,  A61K31/4709 ,  A61P31/18 ,  C07D215/06 ,  C07D401/12

CPC classification number: A61K31/4725 ,  A61K31/47 ,  A61K31/4709 ,  A61P31/18 ,  C07D215/06 ,  C07D401/12

Abstract: The invention relates to isoquinoline and pyridine based CXCR4 antagonists and their use in the treatment and prevention of viral infections such as HIV.