Sulfonates of hydroxycoumarins
    5.
    发明授权
    Sulfonates of hydroxycoumarins 失效
    羟基香豆素磺酸盐

    公开(公告)号:US4618622A

    公开(公告)日:1986-10-21

    申请号:US552787

    申请日:1983-11-17

    CPC分类号: C07D311/80 C07D311/16

    摘要: Sulfonates of hydroxycoumarins of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by --NR.sup.4 R.sup.5, --OR.sup.4 or --OC(O)R.sup.4, where R.sup.4 and R.sup.5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 are each a carboxylic acid group --OC(O)R.sup.4 or a carboxamido radical, with the proviso that R.sup.1 is not methyl when R.sup.2 is hydrogen, or R.sup.1 and R.sup.2 together form a --(CH.sub.2).sub.n -- chain where n is 3-5, and R.sup.3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, --OR.sup.4, --NR.sup.4 R.sup.5, --CN or phenyl, or R.sup.3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group -- NR.sup.4 R.sup.5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by --OR.sup.4, --NR.sup.4 R.sup.5, --NO.sub.2, halogen, --SR.sup.4, --S(O)R.sup.4, --OS(O)R.sup.4, --SCF.sub.3, --OS(O)CF.sub.3, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --NHC(O)R.sup.4, --CF.sub.3, C.sub.1 -C.sub.4 -alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R.sup.1 is methyl and R.sup.2 is hydrogen, for use as drugs.

    摘要翻译: 式I的羟基香豆素的磺酸盐其中R 1和R 2相同或不同,各自为氢,卤素或可被-NR 4 R 5,-OR 4或-OC(O)取代的1至5个碳原子的烷基 )R 4,其中R 4和R 5相同或不同并且各自为氢或1至4个碳原子的烷基,或者R 1和R 2各自为羧酸基-OC(O)R 4或甲酰胺基,条件是R 1 当R 2为氢时,R 1和R 2一起形成 - (CH 2)n - 链,其中n为3-5,R 3为1至8个碳原子的直链或支链烷基或3个环烷基 至8个碳原子,每个可以被卤素,-OR4,-NR4R5,-CN或苯基取代,或R3是3-8个碳原子的直链或支链烯基,氨基-NR4R5或 苯基或萘基,它们各自被-OR4,-NR4R5,-NO2,卤素,-SR4,-S(O)R4,-OS(O)R4,-SCF3,-OS(O)未取代或单取代或多取代, CF 3,-CN,-C(O)R 4,-OC(O)R 4, -NHC(O)R 4,-CF 3,C 1 -C 4烷基或这些取代基的组合,其制备方法,含有这些化合物的药物和式I化合物,其中R 1是甲基,R 2是氢, 用作药物。