公开(公告)号：US4226803A

公开(公告)日：1980-10-07

申请号：US969067

申请日：1978-12-13

Applicant: Karl H. Klingler ,  Horst Traube

Inventor： Karl H. Klingler ,  Horst Traube

IPC: C07B57/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C209/00 ,  C07C211/27 ,  C07C211/29 ,  C07C213/00 ,  C07C213/02 ,  C07C215/30 ,  C07C215/56 ,  C07C215/60 ,  C07C101/04 ,  C07B19/00 ,  C07C91/16 ,  C07C87/28

CPC classification number: C07B31/00 ,  C07B57/00 ,  C07C1/00 ,  C07C209/00 ,  C07C211/27 ,  C07C211/29 ,  C07C213/00 ,  C07C213/02 ,  C07C215/30 ,  C07C215/56 ,  C07C215/60 ,  C07C67/00

Abstract: Optically active bases are prepared by reacting the racemic base with an optically active half amide of an unsaturated aliphatic dicarboxylic acid of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are the same of different and are hydrogen, halogen, a hydroxy group, a methyl group or a methoxy group or two of R.sub.1, R.sub.2 and R.sub.3 together are a methylenedioxy group, R.sub.4 is hydrogen or a methyl group, R.sub.5, R.sub.6 and R.sub.7 independently are hydrogen or a C.sub.1 -C.sub.4 alkyl group and n is 0 or 1 and optionally splitting an optically homogeneous salt fraction into the corresponding optically active base and the added half amide.

Abstract translation: 通过使外消旋碱与式I的不饱和脂族二羧酸的光学活性半酰胺反应制备光学活性碱，其中R 1，R 2和R 3相同，为氢，卤素，羟基， R 1，R 2和R 3中的甲基或甲氧基或二者一起是亚甲二氧基，R 4是氢或甲基，R 5，R 6和R 7独立地是氢或C 1 -C 4烷基，n是0或1 并且任选地将光学上均匀的盐部分分成相应的光学活性碱和加入的半酰胺。