公开(公告)号：US20240092953A1

公开(公告)日：2024-03-21

申请号：US18263730

申请日：2022-02-07

Applicant: KOWA COMPANY, LTD.

Inventor： Ryo KANAYA ,  Kenichi SUZUKI ,  Tsukasa CHIDA ,  Nobuhiro FUJIMAKI ,  Marina ECHIGO ,  Seiji MIURA

IPC: C08F220/28 ,  A61K9/51

CPC classification number: C08F220/286 ,  A61K9/5138 ,  C08F2800/20

Abstract: The present invention provides a novel copolymer available for a drug delivery technique. More particularly, a novel copolymer for a drug delivery carrier targeting a tumor is provided.
The present invention relates to a copolymer comprising structural units represented by the following formulas (A), (B), and (C):






wherein R1, R2, and R3 are the same or different and represent a hydrogen atom or a C1-3 alkyl group, R4 represents a C1-3 alkyl group, R5 represents a hydrogen atom, a C1-18 alkyl group, a 3- to 8-membered cycloalkyl group optionally having a substituent, an adamantyl group, a C6-18 aryl group optionally having a substituent, or a 5- to 10-membered heteroaryl group optionally having a substituent, X1, X2, and X3 are the same or different and represent an oxygen atom, a sulfur atom, or N—R7, R6 represents a hydrogen atom, a leaving group, or a linker, R7 represents a hydrogen atom or a C1-3 alkyl group, m represents an integer of 1 to 100, and n represents an integer of 0 to 3.