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公开(公告)号：US20230039679A1
公开(公告)日：2023-02-09
申请号：US17939147
申请日：2022-09-07
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
发明人： Sung Youn CHANG , Hyuk LEE , Ki Young KIM , Bum Tae KIM , Sung Soo KIM , Seong Hwan KIM , Hwan Jung LIM , Jung Nyoung HEO , Sang Joon SHIN , Sang Youn PARK
IPC分类号： C07D231/38 , A61P35/04 , C07D401/04 , C07D401/14 , C07D403/10 , C07D409/04 , C07D417/04
摘要： The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.
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2.发明公开公开(公告)号：US20240254103A9
公开(公告)日：2024-08-01
申请号：US17914153
申请日：2021-03-12
发明人： Ge Hyeong LEE , Jee Yeon SEO , Jeong Heon YU , In Hae YE , Ho Chul SHIN , Jee Hee SUH , Seong Hwan KIM , Jin Sook SONG , Seong Hyeon SIM , Chong Hak CHAE , Hee Yeon KANG , Ji Hun LEE , Keon Ha HWANG
IPC分类号： C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07D491/18
CPC分类号： C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07D491/18
摘要： The present invention relates to a novel pyrimidine derivative, and a composition for preventing or treating neurodegenerative diseases and cancer, comprising same, the pyrimidine derivative having a LRRK2 protein inhibitory activity, and effectively passing through a blood-brain barrier (BBB) so as to be effectively used as a pharmaceutical composition for preventing or treating neurodegenerative diseases and cancer.
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公开(公告)号：US20240270698A2
公开(公告)日：2024-08-15
申请号：US17785782
申请日：2020-12-16
发明人： Pil Ho KIM , Seong Hwan KIM
IPC分类号： C07D239/48 , A61P35/00 , C07D401/12 , C07D401/14 , C07F9/6512 , C07F9/6541 , C07F9/6558 , C07F9/6561
CPC分类号： C07D239/48 , A61P35/00 , C07D401/12 , C07D401/14 , C07F9/6512 , C07F9/6541 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The present invention relates to a novel pyrimidine derivative and a use thereof. The pyrimidine derivative has excellent MLK3 inhibitory activity and LRRK2 inhibitory activity and thus can be utilized in a pharmaceutical composition for preventing or treating cancers, virus infectious diseases, Parkinson's disease, nonalcoholic fatty liver disease, and tuberculosis.
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公开(公告)号：US20230348399A1
公开(公告)日：2023-11-02
申请号：US17785782
申请日：2020-12-16
发明人： Pil Ho KIM , Seong Hwan KIM
IPC分类号： C07D239/48 , C07F9/6512 , C07F9/6558 , C07F9/6541 , C07D401/12 , C07D401/14 , C07F9/6561 , A61P35/00
CPC分类号： C07D239/48 , C07F9/6512 , C07F9/65583 , C07F9/6541 , C07D401/12 , C07D401/14 , C07F9/6561 , C07F9/65586 , A61P35/00
摘要： The present invention relates to a novel pyrimidine derivative and a use thereof. The pyrimidine derivative has excellent MLK3 inhibitory activity and LRRK2 inhibitory activity and thus can be utilized in a pharmaceutical composition for preventing or treating cancers, virus infectious diseases, Parkinson's disease, nonalcoholic fatty liver disease, and tuberculosis.
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5.发明公开公开(公告)号：US20230219930A1
公开(公告)日：2023-07-13
申请号：US17914153
申请日：2021-03-12
发明人： Ge Hyeong LEE , Jee Yeon SEO , Jeong Heon YU , In Hae YE , Ho Chul SHIN , Jee Hee SUH , Seong Hwan KIM , Jin Sook SONG , Seong Hyeon SIM , Chong Hak CHAE , Hee Yeon KANG , Ji Hun LEE , Keon Ha HWANG
IPC分类号： C07D401/14 , C07D403/04 , C07D405/14 , C07D491/107 , C07D413/14 , C07D491/18 , C07D487/04 , C07D471/04
CPC分类号： C07D401/14 , C07D403/04 , C07D405/14 , C07D491/107 , C07D413/14 , C07D491/18 , C07D487/04 , C07D471/04
摘要： The present invention relates to a novel pyrimidine derivative, and a composition for preventing or treating neurodegenerative diseases and cancer, comprising same, the pyrimidine derivative having a LRRK2 protein inhibitory activity, and effectively passing through a blood-brain barrier (BBB) so as to be effectively used as a pharmaceutical composition for preventing or treating neurodegenerative diseases and cancer.
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公开(公告)号：US20210047300A1
公开(公告)日：2021-02-18
申请号：US16967825
申请日：2019-01-31
申请人： Korea Research Institute of Chemical Technology , Industry-Academic Cooperation Foundation, Yonsei University
发明人： Sung Youn CHANG , Hyuk LEE , Ki Young KIM , Bum Tae KIM , Sung Soo KIM , Seong Hwan KIM , Hwan Jung LIM , Jung Nyoung HEO , Sang Joon SHIN , Sang Youn PARK
IPC分类号： C07D403/12 , C07D413/14 , C07D401/12 , C07D403/14 , C07D413/12 , C07D417/14
摘要： The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.
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公开(公告)号：US20210047277A1
公开(公告)日：2021-02-18
申请号：US16967844
申请日：2019-01-31
申请人： Korea Research Institute of Chemical Technology , Industry-Academic Cooperation Foundation, Yonsei University
发明人： Sung Youn CHANG , Hyuk LEE , Ki Young KIM , Bum Tae KIM , Sung Soo KIM , Seong Hwan KIM , Hwan Jung LIM , Jung Nyoung HEO , Sang Joon SHIN , Sang Youn PARK
IPC分类号： C07D231/38 , C07D403/10 , C07D401/04 , C07D409/04 , C07D417/04 , C07D401/14 , A61P35/04
摘要： The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.
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