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公开(公告)号：US20190135765A1
公开(公告)日：2019-05-09
申请号：US16090072
申请日：2017-03-30
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY
发明人： Tae Bo SIM , Woo Young HUR , Ho Jong YOON , Chi Man SONG , In Jae SHUN , Byeong Yun LIM , HanNa CHO , Seung Hye CHOI , Gu KONG , Jeong Yeon LEE
IPC分类号： C07D239/42 , A61P35/00 , C07D405/12 , C07D409/12 , C07D403/12
摘要： The present invention relates to a novel pyrimidine-4-carboxylic acid derivative having an anticancer activity, and the compound of the present invention is useful as a drug for treating and preventing tumor diseases.
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![THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE DERIVATIVES](/abs-image/US/2018/03/08/US20180065969A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180065969A1
公开(公告)日：2018-03-08
申请号：US15672987
申请日：2017-08-09
发明人： Tae Bo SIM , Han Na CHO , Eun Hye JU , Woo Young HUR , Ho Jong YOON , Chi Man SONG
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a therapeutic agent of acute myeloid leukemia containing a 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one compound as an active ingredient, which has proliferation inhibitory activity for a human acute myeloid leukemia cell line OCI-AML3 having a NRAS mutant gene while having low inhibitory activity for wild type NRAS and has activity of inhibiting GCK and ACK1 protein kinases at the same time.
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公开(公告)号：US20230027716A1
公开(公告)日：2023-01-26
申请号：US17770630
申请日：2020-10-22
发明人： Tae Bo SIM , Seong Shick RYU , Yun Ju NAM , Woo Young HUR
IPC分类号： C07D403/12 , C07D401/14 , C07D401/04 , C07D413/14 , C07D405/14 , A61P35/00
摘要： The present invention relates to: a compound selected from among a novel pyridinyltriazine derivative having protein kinase inhibitory activity, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof; a method for preparing the compound; and a pharmaceutical composition which is for preventing, alleviating, or treating cancer and comprises the compound. A novel compound according to the present invention exhibits excellent inhibitory effects against FGFR, which is a major trigger of bladder cancer, endometrial cancer, etc., point mutations thereof, and various protein kinases other than FGFR involved in signal transduction, and is thus effective as an agent for preventing and treating abnormal cell growth diseases caused by such protein kinases.
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4.发明申请公开(公告)号：US20180050036A1
公开(公告)日：2018-02-22
申请号：US15677742
申请日：2017-08-15
发明人： Tae Bo SIM , Ho Jong YOON , Woo Young HUR , Yun Ju NAM , Hwan Geun CHOI
IPC分类号： A61K31/506
CPC分类号： A61K31/506 , A61K31/519 , A61K31/5377
摘要： The present invention relates to a therapeutic agent for chronic myelogenous leukemia with reduced drug-resistance and side-effects containing a 1,6-disubstituted indole compound.
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5.发明公开公开(公告)号：US20230263792A1
公开(公告)日：2023-08-24
申请号：US18006584
申请日：2021-07-30
发明人： Tae Bo SIM , Seung Hye CHOI , Han Na CHO , Woo Young HUR , Chi Man SONG , Ky Youb NAM , Jeong Hyeok YOON
IPC分类号： A61K31/4535 , A61P35/02 , A61P29/00
CPC分类号： A61K31/4535 , A61P35/02 , A61P29/00
摘要： The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of mastocytosis. The 2,3,5-substituted thiophene compound has excellent inhibitory activity against the growth of mastocytosis cells and against an inflammatory response caused by mastocytosis, and thus may be effectively used for the prevention, amelioration or treatment of mastocytosis.
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![UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS](/abs-image/US/2018/03/08/US20180065970A1/abs.jpg.150x150.jpg)
6.发明申请公开(公告)号：US20180065970A1
公开(公告)日：2018-03-08
申请号：US15674023
申请日：2017-08-10
发明人： Tae Bo SIM , Woo Young HUR , Ho Jong YOON , Chi Man SONG , Eun Hye JU , Han na CHO , Hwan Geun CHOI
IPC分类号： C07D487/04 , C07D401/14 , C07D403/14
CPC分类号： C07D487/04 , A61K31/519 , C07D401/12 , C07D401/14 , C07D403/14
摘要： The present invention provides a pharmaceutical composition, as an effective ingredient, a urea compound having a protein kinase inhibitory activity and containing a 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one skeleton, and a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20160145240A1
公开(公告)日：2016-05-26
申请号：US14947204
申请日：2015-11-20
发明人： Tae Bo SIM , Ho Jong YOON , Ji Hye YOON , Woo Young HUR , Eun Joo ROH , Yeon Ui KWAK
IPC分类号： C07D403/04 , C07D471/04 , C07D487/04 , C07D401/14
CPC分类号： C07D403/04 , C07D401/14 , C07D471/04 , C07D487/04
摘要： A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for preventing and treating a disease caused by abnormal cell growth, which contains the compound as an active ingredient.
摘要翻译： 杂芳基胺化合物包括蛋白激酶抑制活性，其药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其含有该化合物作为活性成分。
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8.发明公开公开(公告)号：US20230270733A1
公开(公告)日：2023-08-31
申请号：US18006582
申请日：2021-07-30
发明人： Tae Bo SIM , Seung Hye CHOI , Han Na CHO , Nam Kyoung KIM , Woo Young HUR , Chi Man SONG , Ky Youb NAM , Jeong Hyeok YOON
IPC分类号： A61K31/4535 , A23L33/10 , A61P35/00
CPC分类号： A61K31/4535 , A23L33/10 , A61P35/00
摘要： The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of gastrointestinal stromal tumor. The 2,3,5-substituted thiophene compound exhibits high inhibitory activity against the growth of gastrointestinal stromal tumor, and thus may be effectively used for the prevention, amelioration or treatment of gastrointestinal stromal tumor.
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![PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND THERAPEUTIC PHARMACEUTIC COMPOSITION COMPRISING SAME](/abs-image/US/2023/04/20/US20230120564A1/abs.jpg.150x150.jpg)
9.发明申请公开(公告)号：US20230120564A1
公开(公告)日：2023-04-20
申请号：US17794314
申请日：2020-07-14
发明人： Tae Bo SIM , Chan Sun PARK , Seung Hye CHOI , Han Na CHO , Sandip SENGUPTA , In Jae SHIN , Woo Young HUR , Jayprakash Narayan KUMAR
IPC分类号： C07D471/04
摘要： The present invention relates to a pyrido[[3,4-d]pyrimidine derivative compound showing excellent anti-proliferative efficacy against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating, or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition for cancer cells. The compound exhibits excellent inhibitory activity and anti-proliferative efficacy against cancer cells, and thus the compound is useful not only for inhibiting cancer cells, but also for preventing cancer metastasis and proliferative diseases or for treating cancer.
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![NOVEL PYRIDO[3,4-D]PYRIMIDIN-8-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING CANCER, COMPRISING SAME](/abs-image/US/2022/05/05/US20220135559A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220135559A1
公开(公告)日：2022-05-05
申请号：US17431591
申请日：2020-02-17
发明人： TAE BO SIM , Woo Young HUR , Chi Man SONG , Sandip SENGUPTA , Chan Sun PARK , Seung Hye CHOI , Han Na CHO , In Jae SHIN
IPC分类号： C07D471/04
摘要： The present disclosure relates to a pyrido[3,4-d]pyrimidin-8-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anticancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.
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