公开(公告)号：US20240132625A1

公开(公告)日：2024-04-25

申请号：US18357665

申请日：2023-07-23

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byung-Ha OH ,  Bo-Seong JEONG ,  Seong-Woo KIM ,  Seong-Bin IM ,  Jinyeop SONG

IPC: C07K16/46 ,  C07K14/47 ,  C07K14/52

CPC classification number: C07K16/46 ,  C07K14/47 ,  C07K14/522 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/54

Abstract: The present invention relates to a conjugate in which a polypeptide capable of forming a dimer is fused to the C-terminus of the heavy chain or light chain of an antibody or fragment thereof, a composition for increasing antigen-binding avidity of an antibody in proportion to the density of a target antigen, and a method for increasing antigen-binding avidity using the same. The present invention also relates to the treatment or diagnosis of diseases using the conjugate.

公开(公告)号：US20240279284A1

公开(公告)日：2024-08-22

申请号：US17924014

申请日：2022-10-11

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byung-Ha OH ,  Seonghoon KIM

IPC: C07K14/00 ,  A61K38/00 ,  A61P35/02

CPC classification number: C07K14/001 ,  A61P35/02 ,  A61K38/00 ,  C07K2319/00

Abstract: The present invention relates to a protein that simultaneously binds to both MCL-1 and BCL-xL and uses thereof. The protein of the present invention simultaneously and specifically binds to both MCL-1 and BCL-xL, which are anti-apoptotic BCL-2 family proteins whose expression is increased in various carcinomas, and thus can be usefully applied to the prevention or treatment of cancers.

公开(公告)号：US20240228669A9

公开(公告)日：2024-07-11

申请号：US18357665

申请日：2023-07-24

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byung-Ha OH ,  Bo-Seong JEONG ,  Seong-Woo KIM ,  Seong-Bin IM ,  Jinyeop SONG

IPC: C07K16/46 ,  C07K14/47 ,  C07K14/52

CPC classification number: C07K16/46 ,  C07K14/47 ,  C07K14/522 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/54

Abstract: The present invention relates to a conjugate in which a polypeptide capable of forming a dimer is fused to the C-terminus of the heavy chain or light chain of an antibody or fragment thereof, a composition for increasing antigen-binding avidity of an antibody in proportion to the density of a target antigen, and a method for increasing antigen-binding avidity using the same. The present invention also relates to the treatment or diagnosis of diseases using the conjugate.