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1.发明申请公开(公告)号：US20190241515A1
公开(公告)日：2019-08-08
申请号：US16312404
申请日：2017-06-22
发明人： Zhenhua Huang , Mei Hong , Chen Jiang
IPC分类号： C07D209/02 , A61P31/04
CPC分类号： C07D209/02 , A61K31/65 , A61P3/10 , A61P31/00 , A61P31/04 , A61P35/00 , C07B2200/13 , C07D209/54
摘要： The present invention belongs to the field of pharmaceutical technology, and crystal forms of a 9-aminomethyl substituted tetracycline compound and a process for preparing the same. More specifically, the present invention relates to crystal forms of the compound represented by formula (1), a process for preparing crystal forms of the compound represented by formula (1) and use of said crystal forms in manufacture of medicament for treating and/or preventing an infection disease caused by tetracycline-sensitive bacteria and/or tetracycline-resistant bacteria.
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公开(公告)号：US09809589B2
公开(公告)日：2017-11-07
申请号：US14653933
申请日：2013-12-23
发明人： Chen Jiang , Aichen Wang , Dedong Zhang
IPC分类号： C07D471/04 , C07D215/20 , C07D215/60 , C07D215/48 , C07C255/50
CPC分类号： C07D471/04 , C07C255/50 , C07D215/20 , C07D215/48 , C07D215/60
摘要： The present invention belongs to the technical field of medicines, and relates to a crystal form of a compound used as a mineralocorticoid receptor antagonist and a preparation method therefor, and in particular, to a method for preparing a compound 2-chloro-4-[(3S,3aR)-3-cyclopentyl-7-(4-hydroxypiperidin-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl]benzonitrile of formula (1); a crystal form thereof, a preparation method for the crystal form, and the use of the crystal form in the preparation of drugs for the treatment and/or prevention of renal injury or cardiovascular diseases.
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