公开(公告)号：US20180080028A1

公开(公告)日：2018-03-22

申请号：US15483528

申请日：2017-04-10

申请人： Kaist IP Co. Ltd.

发明人： Tae Gwan Park ,  Hye Jung Mok ,  Soo Hyeon Lee

IPC分类号： C12N15/113 ,  C12N15/11

CPC分类号： C12N15/1136 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/51

摘要： The present invention relates to a multi-conjugate of small interfering RNA (siRNA) and a preparing method of the same, more precisely a multi-conjugate of siRNA prepared by direct binding of double stranded sense/antisense siRNA monomers or indirect covalent bonding mediated by a cross-linking agent or a polymer, and a preparing method of the same. The preparing method of a siRNA multi-conjugate of the present invention is characterized by simple and efficient reaction and thereby the prepared siRNA multi-conjugate of the present invention has high molecular weight multiple times the conventional siRNA, so that it has high negative charge density, suggesting that it has excellent ionic interaction with a cationic gene carrier and high gene delivery efficiency.

公开(公告)号：US09255269B2

公开(公告)日：2016-02-09

申请号：US14048951

申请日：2013-10-08

申请人： KAIST IP Co. Ltd. ,  Hyo Joo Sohn

发明人： Tae Gwan Park ,  Hye Jung Mok ,  Soo Hyeon Lee

IPC分类号： C12N15/113 ,  C12N15/11

CPC分类号： C12N15/1136 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/51

摘要： The present invention relates to a multi-conjugate of small interfering RNA (siRNA) and a preparing method of the same, more precisely a multi-conjugate of siRNA prepared by direct binding of double stranded sense/antisense siRNA monomers or indirect covalent bonding mediated by a cross-linking agent or a polymer, and a preparing method of the same. The preparing method of a siRNA multi-conjugate of the present invention is characterized by simple and efficient reaction and thereby the prepared siRNA multi-conjugate of the present invention has high molecular weight multiple times the conventional siRNA, so that it has high negative charge density, suggesting that it has excellent ionic interaction with a cationic gene carrier and high gene delivery efficiency.

公开(公告)号：US20190185861A1

公开(公告)日：2019-06-20

申请号：US16040795

申请日：2018-07-20

申请人： Kaist IP Co. Ltd.

发明人： Tae Gwan Park ,  Hye Jung Mok ,  Soo Hyeon Lee

IPC分类号： C12N15/113 ,  C12N15/11

CPC分类号： C12N15/1136 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/51

摘要： The present invention relates to a multi-conjugate of small interfering RNA (siRNA) and a preparing method of the same, more precisely a multi-conjugate of siRNA prepared by direct binding of double stranded sense/antisense siRNA monomers or indirect covalent bonding mediated by a cross -linking agent or a polymer, and a preparing method of the same. The preparing method of a siRNA multi-conjugate of the present invention is characterized by simple and efficient reaction and thereby the prepared siRNA multi -conjugate of the present invention has high molecular weight multiple times the conventional siRNA, so that it has high negative charge density, suggesting that it has excellent ionic interaction with a cationic gene carrier and high gene delivery efficiency.

公开(公告)号：US09644209B2

公开(公告)日：2017-05-09

申请号：US14312530

申请日：2014-06-23

申请人： KAIST IP Co. Ltd.

发明人： Tae Gwan Park ,  Hye Jung Mok ,  Soo Hyeon Lee

IPC分类号： C12N15/11 ,  C12N15/113

CPC分类号： C12N15/1136 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/51

摘要： The present invention relates to a multi-conjugate of small interfering RNA (siRNA) and a preparing method of the same, more precisely a multi-conjugate of siRNA prepared by direct binding of double stranded sense/antisense siRNA monomers or indirect covalent bonding mediated by a cross-linking agent or a polymer, and a preparing method of the same. The preparing method of a siRNA multi-conjugate of the present invention is characterized by simple and efficient reaction and thereby the prepared siRNA multi-conjugate of the present invention has high molecular weight multiple times the conventional siRNA, so that it has high negative charge density, suggesting that it has excellent ionic interaction with a cationic gene carrier and high gene delivery efficiency.