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公开(公告)号：US06921826B2
公开(公告)日：2005-07-26
申请号：US10696684
申请日：2003-10-29
IPC分类号： A61K31/4745 , A61K31/506 , A61P1/16 , A61P7/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/02 , A61P17/12 , A61P17/14 , A61P25/00 , A61P31/02 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D471/04
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US07288550B2
公开(公告)日：2007-10-30
申请号：US11132537
申请日：2005-05-19
IPC分类号： A61K31/4353 , C07D471/04
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1-位含有硫醚官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US06667312B2
公开(公告)日：2003-12-23
申请号：US10165222
申请日：2002-06-07
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06949649B2
公开(公告)日：2005-09-27
申请号：US10696477
申请日：2003-10-29
IPC分类号： A61K31/4745 , A61P31/02 , A61P31/12 , A61P37/02 , C07D471/04 , C07D487/02
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06664264B2
公开(公告)日：2003-12-16
申请号：US10013059
申请日：2001-12-06
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06525064B1
公开(公告)日：2003-02-25
申请号：US10165002
申请日：2002-06-07
申请人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
发明人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有磺酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US06720334B2
公开(公告)日：2004-04-13
申请号：US10358017
申请日：2003-02-04
申请人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
发明人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有脲或硫脲官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US06677348B2
公开(公告)日：2004-01-13
申请号：US10165750
申请日：2002-06-07
申请人： Phillip D. Heppner , Leslie J. Charles , Joseph F. Dellaria , Bryon A. Merrill , John W. Mickelson
发明人： Phillip D. Heppner , Leslie J. Charles , Joseph F. Dellaria , Bryon A. Merrill , John W. Mickelson
IPC分类号： A61K314745
CPC分类号： C07D471/04
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06989389B2
公开(公告)日：2006-01-24
申请号：US10696108
申请日：2003-10-29
申请人： Philip D. Heppner , Leslie J. Charles , Joseph F. Dellaria , Bryon A. Merrill , John W. Mickelson
发明人： Philip D. Heppner , Leslie J. Charles , Joseph F. Dellaria , Bryon A. Merrill , John W. Mickelson
IPC分类号： A61K31/4745 , C07D471/04 , A61P37/02 , A61P31/12
CPC分类号： C07D471/04
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06716988B2
公开(公告)日：2004-04-06
申请号：US10357777
申请日：2003-02-04
IPC分类号： C07D213643
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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