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1.发明授权Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines 有权协同抗炎药物组合物和使用姜黄素或甲基黄嘌呤的相关方法公开(公告)号：US08193201B2
公开(公告)日：2012-06-05
申请号：US13073388
申请日：2011-03-28
IPC分类号： A01N43/90 , A01N31/00 , A61K31/522 , A61K31/45
CPC分类号： A61K31/522 , A61K31/12 , A61K31/19 , A61K36/185 , A61K36/9066 , A61K45/06 , A61K2300/00
摘要： The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.
摘要翻译： 本发明提供了含有从啤酒花和甲基黄嘌呤中分离或衍生的级分的组合物。 本发明另外提供了含有源自啤酒花和姜黄素的级分的组合物。 本发明还提供了使用这种组合物减少炎症的方法。
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2.发明授权Compositions that treat or inhibit pathological conditions associated with inflammatory response 有权治疗或抑制与炎症反应相关的病理状况的组合物公开(公告)号：US08168234B2
公开(公告)日：2012-05-01
申请号：US11729696
申请日：2007-03-29
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K31/203 , A61K36/53 , A61K2300/00
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。
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3.发明申请XANTHOHUMOL AND TETRAHYDRO-ISOALPHA ACID BASED PROTEIN KINASE MODULATION CANCER TREATMENT 审中-公开甘氨酸和四氢叶酸 - 基于醋酸的蛋白质激酶调控癌症治疗公开(公告)号：US20110021637A1
公开(公告)日：2011-01-27
申请号：US12754820
申请日：2010-04-06
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
CPC分类号： A61K31/12 , A61K31/122 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
摘要翻译： 公开了用于癌症治疗的蛋白激酶调节的化合物和方法。 所公开的化合物和方法基于黄曲霉醇或异山梨醇或通常在啤酒花中发现的四氢异α-酸。
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公开(公告)号：US07794757B2
公开(公告)日：2010-09-14
申请号：US11403034
申请日：2006-04-12
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K31/12
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
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5.发明申请NOVEL MITOCHONDRIAL UNCOUPLING METHODS AND COMPOSITIONS FOR ENHANCING ADIPOCYTE THERMOGENESIS 审中-公开新型麻醉解除方法和组合物，用于增强ADIPOCYTE THERMOGENESIS公开(公告)号：US20100215782A1
公开(公告)日：2010-08-26
申请号：US12581967
申请日：2009-10-20
IPC分类号： A61K36/00 , A61K36/185 , A61K36/82 , A61K36/38 , A61K36/899 , A61K31/235 , A61K31/12 , A61K31/05 , A61P3/00 , A61K36/48 , A61K36/72
CPC分类号： A61K31/05 , A61K36/00 , A61K2300/00
摘要： Disclosed are methods, compounds, and compositions comprising botanically based drugs, medical foods, and dietary supplements for the prevention and treatment of metabolic disorders, in particular obesity, weight gain, insulin resistance syndromes, diabetes, fasting hyperlipidemia and osteoarthritis. More specifically, the invention relates to pharmaceutical therapeutic methods and compositions utilizing phytochemicals, natural plant extracts and combinations to modify adipocyte physiology to enhance thermogenesis and modify cytokine secretion.
摘要翻译： 本发明涉及用于预防和治疗代谢紊乱，特别是肥胖，体重增加，胰岛素抵抗综合征，糖尿病，禁食性高脂血症和骨关节炎的基于植物药物的药物，医疗食品和膳食补充剂的方法，化合物和组合物。 更具体地，本发明涉及利用植物化学物质，天然植物提取物和组合来改变脂肪细胞生理学以增强产热和修饰细胞因子分泌的药物治疗方法和组合物。
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6.发明申请SUBSTITUTED 1,3-CYCLOPENTADIONE MULTI-TARGET PROTEIN KINASE MODULATORS OF CANCER, ANGIOGENESIS AND THE INFLAMMATORY PATHWAYS ASSOCIATED THEREWITH 审中-公开取代的1,3-CYCLOPENTADIONE多靶点蛋白激酶调节因子与癌细胞，血管生成以及与之相关的炎症途径公开(公告)号：US20100137449A1
公开(公告)日：2010-06-03
申请号：US12331887
申请日：2008-12-10
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Anu Desai , Gary Darland , Brian J. Carroll , James S. Traub , Linda M. Pacioretty , Dennis Emma
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Anu Desai , Gary Darland , Brian J. Carroll , James S. Traub , Linda M. Pacioretty , Dennis Emma
IPC分类号： A61K31/122 , A61P35/00 , A61P9/10
CPC分类号： A61K31/12 , A61K45/06 , A61K2300/00
摘要： Compounds and methods for multi-targeted protein kinase modulation for angiogenesis, cancer treatment or the inflammatory pathways associated with those conditions are disclosed. The compounds and methods disclosed are based on substituted 1,3-cyclopentadione compounds.
摘要翻译： 公开了用于血管生成，癌症治疗或与这些病症相关的炎症途径的多靶向蛋白激酶调节的化合物和方法。 所公开的化合物和方法是基于取代的1,3-环戊二酮化合物。
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7.发明申请Inhibition of COX-2 and/or 5-LOX activity by fractions isolated or derived from hops 有权通过分离或衍生自啤酒花的级分抑制COX-2和/或5-LOX活性公开(公告)号：US20090118373A1
公开(公告)日：2009-05-07
申请号：US10866315
申请日：2004-06-10
CPC分类号： A61K31/19
摘要： A natural formulation of compounds isolated or derived from hops which inhibit the activity of cyclooxygenase-2 (COX-2) and/or 5-lipoxygenase (5-LOX) is disclosed. The hops formulations may be administered to a mammal to treat or inhibit a pathological condition associated with the activity of COX-2 and/or 5-LOX in such a mammal.
摘要翻译： 公开了分离或衍生自抑制环氧合酶-2（COX-2）和/或5-脂氧合酶（5-LOX）的活性的啤酒花的化合物的天然制剂。 可将哺乳动物制剂施用于哺乳动物以治疗或抑制与哺乳动物中COX-2和/或5-LOX的活性相关的病理状况。
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8.发明授权Compositions that treat or inhibit pathological conditions associated with inflammatory response 失效治疗或抑制与炎症反应相关的病理状况的组合物公开(公告)号：US08486457B2
公开(公告)日：2013-07-16
申请号：US10532388
申请日：2003-10-20
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K31/122 , A61K36/53 , A61K2300/00
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。
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公开(公告)号：US08263139B2
公开(公告)日：2012-09-11
申请号：US11501393
申请日：2006-08-09
申请人： Matthew L. Tripp , John G. Babish , Linda M. Pacioretty , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Linda M. Pacioretty , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Anu Desai
IPC分类号： A61K36/00
CPC分类号： A61K36/185 , A61K31/12 , A61K36/48 , A61K45/06 , A61K2300/00
摘要： Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or Acacia.
摘要翻译： 公开了调节激酶活性的植物化合物。 所公开的化合物和方法还抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并且选择性地抑制炎症反应。 组合物含有至少一个分离或衍生自啤酒花或金合欢的馏分。
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10.发明授权Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines 有权协同抗炎药物组合物和使用姜黄素或甲基黄嘌呤的相关方法公开(公告)号：US07914831B2
公开(公告)日：2011-03-29
申请号：US10789817
申请日：2004-02-27
IPC分类号： A01N65/00 , A01N43/90 , A01N37/00 , A01N35/00 , A61K36/00 , A61K31/52 , A61K31/19 , A61K31/12
CPC分类号： A61K31/522 , A61K31/12 , A61K31/19 , A61K36/185 , A61K36/9066 , A61K45/06 , A61K2300/00
摘要： The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.
摘要翻译： 本发明提供了含有从啤酒花和甲基黄嘌呤中分离或衍生的级分的组合物。 本发明另外提供了含有源自啤酒花和姜黄素的级分的组合物。 本发明还提供了使用这种组合物减少炎症的方法。
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