公开(公告)号：US20120270837A1

公开(公告)日：2012-10-25

申请号：US13459898

申请日：2012-04-30

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A61K31/122 ,  A61K31/7008 ,  A61P29/00 ,  C12N5/071

CPC分类号： A61K31/12 ,  A61K31/203 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

公开(公告)号：US08257754B2

公开(公告)日：2012-09-04

申请号：US13430154

申请日：2012-03-26

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence M. Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence M. Howell

IPC分类号： A01N65/00

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US20120183634A1

公开(公告)日：2012-07-19

申请号：US13430154

申请日：2012-03-26

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A61K36/53 ,  A61P29/00

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US07820206B2

公开(公告)日：2010-10-26

申请号：US11344554

申请日：2006-01-30

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K36/185 ,  A61K31/12

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.

公开(公告)号：US07722903B2

公开(公告)日：2010-05-25

申请号：US11344559

申请日：2006-01-30

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K36/185 ,  A61K31/12

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。

公开(公告)号：US07431948B2

公开(公告)日：2008-10-07

申请号：US11403016

申请日：2006-04-12

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K45/06 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

公开(公告)号：US07270835B2

公开(公告)日：2007-09-18

申请号：US10689856

申请日：2003-10-20

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary K. Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K45/06 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US20100184857A1

公开(公告)日：2010-07-22

申请号：US12564174

申请日：2009-09-22

申请人： John G. Babish ,  Matthew L. Tripp ,  Jeffrey S. Bland ,  Terrence Howell ,  Gary K. Darland ,  Robert H. Lerman ,  Daniel O. Lukaczer

发明人： John G. Babish ,  Matthew L. Tripp ,  Jeffrey S. Bland ,  Terrence Howell ,  Gary K. Darland ,  Robert H. Lerman ,  Daniel O. Lukaczer

IPC分类号： A61K31/122 ,  A61K31/215

CPC分类号： A61K31/12 ,  A61K31/192 ,  A61K36/185 ,  A61K2300/00

摘要： The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.

摘要翻译： 本发明提供啤酒花（Humulus lupulus）提取物或其衍生物，其用于预防性和/或治疗性地对胃和/或肠的溃疡型障碍进行治疗。 溃疡性疾病可以是化学诱导型，环境诱导型，感染诱导型和/或应激诱导型。 本发明还提供了包含活力量的啤酒花提取物或其衍生物与止痛化合物和/或抗炎化合物组合的药物组合物。 本发明进一步提供啤酒花提取物或其衍生物的使用，显着减少和/或治疗性地治疗胃和/或肠的溃疡形成型疾病。

公开(公告)号：US07666449B2

公开(公告)日：2010-02-23

申请号：US11355145

申请日：2006-02-15

申请人： John G. Babish ,  Matthew L. Tripp ,  Jeffrey S. Bland ,  Terrence Howell ,  Gary K. Darland ,  Robert H. Lerman ,  Daniel O. Lukaczer

发明人： John G. Babish ,  Matthew L. Tripp ,  Jeffrey S. Bland ,  Terrence Howell ,  Gary K. Darland ,  Robert H. Lerman ,  Daniel O. Lukaczer

IPC分类号： A01N65/00

CPC分类号： A61K31/12 ,  A61K31/192 ,  A61K36/185 ,  A61K2300/00

摘要： The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.

摘要翻译： 本发明提供啤酒花（Humulus lupulus）提取物或其衍生物，其用于预防性和/或治疗性地对胃和/或肠的溃疡型障碍进行治疗。 溃疡性疾病可以是化学诱导型，环境诱导型，感染诱导型和/或应激诱导型。 本发明还提供了包含活力量的啤酒花提取物或其衍生物与止痛化合物和/或抗炎化合物组合的药物组合物。 本发明进一步提供啤酒花提取物或其衍生物的使用，显着减少和/或治疗性地治疗胃和/或肠的溃疡形成型疾病。

公开(公告)号：US06210701B1

公开(公告)日：2001-04-03

申请号：US09302693

申请日：1999-04-30

申请人： Gary K. Darland ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Tracey A. Irving ,  Jeffrey S. Bland

发明人： Gary K. Darland ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Tracey A. Irving ,  Jeffrey S. Bland

IPC分类号： A61K4700

CPC分类号： A61K36/899 ,  A23L33/105 ,  A23L33/22 ,  A23V2002/00 ,  A61K36/53 ,  A61K36/9068 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2250/1944 ,  A23V2250/70 ,  A23V2250/5482

摘要： The present invention provides dietary supplements, medical foods and methods effective to ameliorate at least one of the symptoms, preferably all of the symptoms, of an inflammation-related disease. The dietary supplements of the present invention include rosemary, curcumin and at least one component selected from the group consisting of quercetin and rutin. The medical foods of the present invention include rosemary and at least one component selected from the group consisting of curcumin, quercetin and rutin. The medical foods of the present invention also include macronutrients. The methods of the present invention include the step of administering to a person suffering from an inflammation-related disease an effective amount of a dietary supplement or medical food of the present invention.

摘要翻译： 本发明提供了有效地改善炎症相关疾病的症状，优选全部症状中的至少一种的膳食补充剂，医疗食品和方法。 本发明的膳食补充剂包括迷迭香，姜黄素和选自槲皮素和芦丁中的至少一种成分。 本发明的医疗食品包括迷迭香和至少一种选自姜黄素，槲皮素和芦丁的成分。 本发明的医疗食品还包括大量营养素。 本发明的方法包括向患有炎症相关疾病的人施用有效量的本发明的膳食补充剂或医疗食品的步骤。