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1.发明授权Drug delivery system toward demyelinating lesion and biochemical marker of demyelinating lesion 失效脱髓鞘病变的药物输送系统和脱髓鞘病变的生化标志物公开(公告)号：US08252540B2
公开(公告)日：2012-08-28
申请号：US12671856
申请日：2008-08-01
申请人： Jin Nakahara , Sadakazu Aiso , Norihiro Suzuki
发明人： Jin Nakahara , Sadakazu Aiso , Norihiro Suzuki
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , A61K47/6849 , C07K16/18 , G01N2333/70503 , G01N2800/285
摘要： It is intended to provide a drug delivery system toward a demyelinating lesion. It is also intended to provide a biochemical marker of a demyelinating lesion. A delivery system for a prophylactic and/or therapeutic agent for a demyelinating disease characterized in that a substance capable of specifically recognizing Contactin is conjugated to an active ingredient of a prophylactic and/or therapeutic agent for a demyelinating disease is provided. Also provided is a method of evaluating and/or differentiating a demyelinating disease, including measuring the expression of Contactin in a body fluid.
摘要翻译： 旨在为脱髓鞘病变提供药物递送系统。 它还旨在提供脱髓鞘病变的生化标志物。 提供了用于脱髓鞘疾病的预防和/或治疗剂的递送系统，其特征在于，能够特异性识别接触蛋白的物质与用于脱髓鞘疾病的预防和/或治疗剂的活性成分缀合。 还提供了评估和/或分化脱髓鞘疾病的方法，包括测量体液中的接触蛋白的表达。
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2.发明申请DRUG DELIVERY SYSTEM TOWARD DEMYELINATING LESION AND BIOCHEMICAL MARKER OF DEMYELINATING LESION 失效药物递送系统，流式细胞仪和生物化学标记物公开(公告)号：US20110250214A1
公开(公告)日：2011-10-13
申请号：US12671856
申请日：2008-08-01
申请人： Jin Nakahara , Sadakazu Aiso , Norihiro Suzuki
发明人： Jin Nakahara , Sadakazu Aiso , Norihiro Suzuki
CPC分类号： G01N33/74 , A61K47/6849 , C07K16/18 , G01N2333/70503 , G01N2800/285
摘要： It is intended to provide a drug delivery system toward a demyelinating lesion. It is also intended to provide a biochemical marker of a demyelinating lesion. A delivery system for a prophylactic and/or therapeutic agent for a demyelinating disease characterized in that a substance capable of specifically recognizing Contactin is conjugated to an active ingredient of a prophylactic and/or therapeutic agent for a demyelinating disease is provided. Also provided is a method of evaluating and/or differentiating a demyelinating disease, including measuring the expression of Contactin in a body fluid.
摘要翻译： 旨在为脱髓鞘病变提供药物递送系统。 它还旨在提供脱髓鞘病变的生化标志物。 提供了用于脱髓鞘疾病的预防和/或治疗剂的递送系统，其特征在于，能够特异性识别接触蛋白的物质与用于脱髓鞘疾病的预防和/或治疗剂的活性成分缀合。 还提供了评估和/或分化脱髓鞘疾病的方法，包括测量体液中的接触蛋白的表达。
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公开(公告)号：US20070178083A1
公开(公告)日：2007-08-02
申请号：US11451488
申请日：2006-06-13
申请人： Jin Nakahara , Hiroaki Asou , Sadakazu Aiso
发明人： Jin Nakahara , Hiroaki Asou , Sadakazu Aiso
IPC分类号： A61K39/395
CPC分类号： A61K45/00 , C07K16/283
摘要： The present invention provides pharmaceutical compositions composing, as an active ingredient, a substance capable of activating the γ chain of Fc receptors (FcRγ) (provided that the substance is not an immunoglobulin for intravenous injection), and agents for stimulating myelinogenesis. The invention also provides agents for stimulating the differentiation of oligodendroglial precursor cells, agents for activating Fyn tyrosine kinase, and agents for stimulating the expression of myelin basic protein, all comprising a substance capable of activating FcRγ as an active ingredient. Further, the invention provides a method of detecting myelinogenetic oligodendroglias or precursor cells thereof which comprises using the expression of FcRγ in oligodendroglias or precursor cells thereof as an indicator.
摘要翻译： 本发明提供作为活性成分构成能够活化Fc受体（FcRγ）的γ链（条件是该物质不是用于静脉内注射的免疫球蛋白）的药物组合物和用于刺激髓鞘形成的药剂的药物组合物。 本发明还提供用于刺激少突神经母细胞前体细胞分化的药剂，用于激活Fyn酪氨酸激酶的药剂和用于刺激髓磷脂碱性蛋白质表达的试剂，所有这些药物都包含能够激活FcRγ作为活性成分的物质。 此外，本发明提供了检测髓鞘发生少突胶质细胞或其前体细胞的方法，其包括使用寡突神经胶质瘤或其前体细胞中的FcRγ的表达作为指标。
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公开(公告)号：US07901678B2
公开(公告)日：2011-03-08
申请号：US11451488
申请日：2006-06-13
申请人： Jin Nakahara , Hiroaki Asou , Sadakazu Aiso
发明人： Jin Nakahara , Hiroaki Asou , Sadakazu Aiso
IPC分类号： A61K39/395
CPC分类号： A61K45/00 , C07K16/283
摘要： The present invention provides pharmaceutical compositions composing, as an active ingredient, a substance capable of activating the γ chain of Fc receptors (FcRγ) (provided that the substance is not an immunoglobulin for intravenous injection), and agents for stimulating myelinogenesis. The invention also provides agents for stimulating the differentiation of oligodendroglial precursor cells, agents for activating Fyn tyrosine kinase, and agents for stimulating the expression of myelin basic protein, all comprising a substance capable of activating FcRγ as an active ingredient. Further, the invention provides a method of detecting myelinogenetic oligodendroglias or precursor cells thereof which comprises using the expression of FcRγ in oligodendroglias or precursor cells thereof as an indicator.
摘要翻译： 本发明提供作为活性成分构成能够激活Fc受体（FcRγ）的γ链（前提是该物质不是用于静脉内注射的免疫球蛋白）的药物组合物和刺激髓鞘形成的药剂的药物组合物。 本发明还提供用于刺激少突神经母细胞前体细胞分化的药剂，用于激活Fyn酪氨酸激酶的药剂和用于刺激髓磷脂碱性蛋白质表达的试剂，全部包含能够激活FcRγ作为活性成分的物质。 此外，本发明提供了检测骨髓发生少突胶质细胞或前体细胞的方法，其包括使用少突胶质细胞中的FcRγ或其前体细胞的表达作为指标。
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公开(公告)号：US20050175998A1
公开(公告)日：2005-08-11
申请号：US10485614
申请日：2002-07-22
申请人： Jin Nakahara , Hiroaki Asou , Sadakazu Aiso
发明人： Jin Nakahara , Hiroaki Asou , Sadakazu Aiso
CPC分类号： A61K45/00 , C07K16/283
摘要： The present invention provides pharmaceutical compositions comprising, as an active ingredient, a substance capable of activating the γ chain of Fc receptors (FcRγ) (provided that the substance is not an immunoglobulin for intravenous injection), and agents for stimulating myelinogenesis. The invention also provides agents for stimulating the differentiation of oligodendroglial precursor cells, agents for activating Fyn tyrosine kinase, and agents for stimulating the expression of myelin basic protein, all comprising a substance capable of activating FcRγ as an active ingredient. Further, the invention provides a method of detecting myelinogenetic oligodenroglias or precursor cells thereof which comprises using the expression of FcRγ in oligodendroglias or precursor cells thereof as an indicator.
摘要翻译： 本发明提供药物组合物，其包含作为活性成分的能够激活Fc受体（FcRγ）的γ链的物质（前提是该物质不是用于静脉内注射的免疫球蛋白）和用于刺激髓鞘形成的试剂。 本发明还提供用于刺激少突神经母细胞前体细胞分化的药剂，用于激活Fyn酪氨酸激酶的药剂和用于刺激髓磷脂碱性蛋白质表达的试剂，所有这些药物都包含能够激活FcRγ作为活性成分的物质。 此外，本发明提供了检测髓鞘发生性少突神经母细胞或其前体细胞的方法，其包括以少突胶质多糖或其前体细胞中的FcRγ的表达作为指标。
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