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公开(公告)号：US06452028B1
公开(公告)日：2002-09-17
申请号：US09648825
申请日：2000-08-25
申请人： Andrew David Batcho , Bernard Michael Hennessy , Jerome Anthony Iacobelli , Milan Radoje Uskokovic
发明人： Andrew David Batcho , Bernard Michael Hennessy , Jerome Anthony Iacobelli , Milan Radoje Uskokovic
IPC分类号： C07C40100
CPC分类号： C07C401/00 , A61K31/59
摘要： A compound of the formula wherein R is hydrogen or hydroxy, each R1 is ethyl, propyl, butyl, isopropyl or t-butyl, X is ═CH2, or when R is hydroxy, X is hydrogen or ═CH2, and A is —C≡C—, or —CH2—CH2—. These compounds are useful for the treatment of hyperproliferative disorders, skin diseases, and sebaceous gland diseases.
摘要翻译： 式R的化合物是氢或羟基，每个R 1是乙基，丙基，丁基，异丙基或叔丁基，X是= CH 2，或当R是羟基时，X是氢或= CH 2，A是-C = C-或-CH 2 -CH 2 - 。这些化合物可用于治疗过度增生性疾病，皮肤病和皮脂腺疾病。
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2.发明授权
公开(公告)号：US3993675A
公开(公告)日：1976-11-23
申请号：US552027
申请日：1975-02-24
CPC分类号： C07J9/00 , Y02P20/582
摘要： A novel process for the preparation of 1.alpha.,25-dihydroxycholecalciferol and intermediates thereof is disclosed.
摘要翻译： 公开了一种制备1α，25-二羟基胆钙化甾醇及其中间体的新方法。
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公开(公告)号：US6030963A
公开(公告)日：2000-02-29
申请号：US127449
申请日：1998-07-31
IPC分类号： A61K31/59 , A61K31/00 , A61P35/00 , C07C35/32 , C07C45/29 , C07C45/30 , C07C49/513 , C07C401/00 , A01N45/00
CPC分类号： C07C401/00 , C07C35/32 , C07C45/292 , C07C45/305 , C07C49/513
摘要： The invention relates to a compound of the formula ##STR1## wherein A is ##STR2## Et is ethyl, and R is hydroxy and R.sup.1 is hydrogen or .dbd.CH.sub.2 or R is hydrogen or fluoro and R.sup.1 is .dbd.CH.sub.2. Compounds of formula I stimulate HL-60 cell differentiation. Accordingly, the compounds of formula I are useful as agents for the treatment of neoplastic diseases, such as leukemia.
摘要翻译： 本发明涉及下式的化合物其中A是Et是乙基，R是羟基，R 1是氢或= CH 2或R是氢或氟并且R 1是= CH 2。 式I的化合物刺激HL-60细胞分化。 因此，式I化合物可用作治疗肿瘤性疾病如白血病的药剂。
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公开(公告)号：US5939408A
公开(公告)日：1999-08-17
申请号：US163037
申请日：1998-09-29
申请人： Andrew David Batcho , Bernard Michael Hennessy , Jerome Anthony Iacobelli , Milan Radoje Uskokovic
发明人： Andrew David Batcho , Bernard Michael Hennessy , Jerome Anthony Iacobelli , Milan Radoje Uskokovic
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： C07C401/00 , A61K31/59
摘要： Compounds of the formula ##STR1## wherein R is hydrogen, fluorine, or hydroxyl, each R.sub.2 is lower alkyl or C(R.sub.3).sub.3 and R.sub.3 is halogen, X is .dbd.CH.sub.2 or when R is hydroxy, X is hydrogen or .dbd.CH.sub.2, and A is --C.tbd.C-- ##STR2## or --CH.sub.2 --CH.sub.2 --, which are useful in the treatment of hyperproliferative skin disorders, neoplastic diseases, and sebaceous gland diseases.
摘要翻译： 下式的化合物其中R是氢，氟或羟基，每个R 2是低级烷基或C（R 3）3，并且R 3是卤素，X是= CH 2或当R是羟基时，X是氢或= CH 2，A是 -C 3OND C或-CH 2 -CH 2 - ，其可用于治疗过度增生性皮肤病，肿瘤性疾病和皮脂腺疾病。
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公开(公告)号：US06329538B1
公开(公告)日：2001-12-11
申请号：US09648817
申请日：2000-08-25
申请人： Andrew David Batcho , Bernard Michael Hennessy , Jerome Anthony Iacobelli , Milan Radoje Uskokovic
发明人： Andrew David Batcho , Bernard Michael Hennessy , Jerome Anthony Iacobelli , Milan Radoje Uskokovic
IPC分类号： C07C40100
CPC分类号： C07C401/00 , A61K31/59
摘要： A compound of the formula wherein R is hydrogen or hydroxy, each R2 is independently H or halogen, X is ═CH2, or when R is hydroxy, X is hydrogen or ═CH2, and A is —C≡C—, or —CH2—CH2—, provided that when A is —CH2—CH2—, R2 is H.
摘要翻译： 式R的化合物是氢或羟基，每个R 2独立地为H或卤素，X为= CH 2，或当R为羟基时，X为氢或= CH 2，A为-C = C-或-CH 2 - CH 2 - ，条件是当A是-CH 2 -CH 2 - 时，R 2是H.
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6.发明授权
公开(公告)号：US5840718A
公开(公告)日：1998-11-24
申请号：US811809
申请日：1997-03-06
CPC分类号： C07F7/1844 , C07F7/1856
摘要： The invention relates to a compound of the formula ##STR1## wherein R is hydroxy and R.sup.1 is H.sub.2 or .dbd.CH.sub.2 or R is hydrogen or fluoro and R.sup.1 is .dbd.CH.sub.2 and (b) an inert carrier. Compounds of formula I are useful as agents for the treatment of hyperproliferative skin diseases, such as psoriasis, neoplastic diseases, such as leukemia, and sebaceous gland diseases, such as acne and sebhorreic dermatitis.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R为羟基，R 1为H 2或= CH 2或R为氢或氟并且R 1为= CH 2和（b）惰性载体。 式I化合物可用作治疗过度增生性皮肤病的药剂，例如牛皮癣，肿瘤性疾病如白血病和皮脂腺疾病如痤疮和皮脂腺性皮炎。
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公开(公告)号：US5856317A
公开(公告)日：1999-01-05
申请号：US653551
申请日：1996-05-24
IPC分类号： A61K31/59
CPC分类号： A61K31/593 , A61K31/59
摘要： A method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D.sub.3 analog, as well as a method of inducing loss of cell proliferation in solid tumors utilizing trans retinoic acid and a Vitamin D.sub.3 analog.In another aspect, a method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D.sub.3 metabolite, as well as a method of inducing loss of cell proliferation in solid tumors utilizing trans retinoic acid and a Vitamin D.sub.3 metabolite.
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8.发明授权Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs 失效用维生素D3氟化类似物治疗过度增生性皮肤病的方法
公开(公告)号：US5753638A
公开(公告)日：1998-05-19
申请号：US458591
申请日：1995-06-02
IPC分类号： C07C35/52 , C07C45/29 , C07C49/743 , C07C401/00 , C07F7/18 , A61K31/59
CPC分类号： C07F7/1856 , A61K31/593 , A61K9/0014 , A61K9/4858
摘要： Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
摘要翻译： 其中R为氢，羟基或氟的式（I）化合物可用作治疗皮肤过度增生性疾病的药剂，例如牛皮癣，作为治疗白血病的药物，以及作为治疗皮脂腺的药剂 腺体疾病，如痤疮和脂溢性皮炎。
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9.发明授权Method of treating sebaceous gland diseases with vitamin D.sub.3 fluorinated analogs 失效用维生素D3氟化类似物治疗皮脂腺疾病的方法
公开(公告)号：US5750517A
公开(公告)日：1998-05-12
申请号：US609804
申请日：1996-03-01
IPC分类号： C07C35/52 , C07C45/29 , C07C49/743 , C07C401/00 , C07F7/18 , A01N45/00
CPC分类号： C07F7/1856 , A61K31/593 , A61K9/0014 , A61K9/4858
摘要： Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
摘要翻译： 其中R为氢，羟基或氟的式（I）化合物可用作治疗皮肤过度增生性疾病的药剂，例如牛皮癣，作为治疗白血病的药物，以及作为治疗皮脂腺的药剂 腺体疾病，如痤疮和脂溢性皮炎。
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公开(公告)号：US4062868A
公开(公告)日：1977-12-13
申请号：US771218
申请日：1977-02-23
申请人： Pasquale Nicholas Confalone , Elizabeth Dianne Lollar , Giacomo Pizzolato , Milan Radoje Uskokovic
发明人： Pasquale Nicholas Confalone , Elizabeth Dianne Lollar , Giacomo Pizzolato , Milan Radoje Uskokovic
IPC分类号： A01N43/90 , C07D333/24 , C07D333/80 , C07D495/04 , C07D495/06 , C07D498/06 , A01N9/00 , A01N9/22
CPC分类号： C07D495/04 , C07D333/80
摘要： A novel process for the preparation of biotin is disclosed wherein said process employs inexpensive starting materials and reagents resulting in the obtention of biotin devoid of the biologically inactive stereoisomers.
摘要翻译： 公开了一种制备生物素的新方法，其中所述方法使用便宜的原料和试剂，导致获得没有生物活性的立体异构体的生物素。
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