公开(公告)号：US20220306738A1

公开(公告)日：2022-09-29

申请号：US17702042

申请日：2022-03-23

Applicant: Janssen Biotech, Inc.

Inventor： Kyle J. Bednar ,  Naresh Kumar ,  Sanjaya Singh ,  Danlin Yang ,  Rajkumar Ganesan

IPC: C07K16/28 ,  C07K16/46

Abstract: Provided herein are multispecific antibodies, that bind to CD79b and CD22, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US12103977B2

公开(公告)日：2024-10-01

申请号：US17702282

申请日：2022-03-23

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  Anna Kuchnio ,  Cassandra L. Lowenstein ,  Ulrike Philippar ,  Sanjaya Singh ,  Nele Vloemans ,  Danlin Yang

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2896 ,  A61P35/00 ,  C07K16/2878 ,  C07K16/2887 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are multispecific antibodies, including trispecific antibodies that bind to CD79b, CD20 and CD3, and bispecific antibodies that bind to CD79b and CD3, and multispecific antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided multispecific antibodies or multispecific antigen-binding fragments, cells expressing the provided multispecific antibodies or multispecific antigen-binding fragments, as well as associated vectors and detectably labeled multispecific antibodies or multispecific antigen-binding fragments. In addition, methods of producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described. Further provided herein are isolated antibodies that bind to CD79b and antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided CD79b-specific antibodies or antigen-binding fragments, cells expressing the provided CD79b-specific antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled CD79b-specific antibodies or antigen-binding fragments. In addition, methods of producing and using the provided CD79b-specific antibodies and antigen-binding fragments are described.

公开(公告)号：US20250066474A1

公开(公告)日：2025-02-27

申请号：US18946033

申请日：2024-11-13

Applicant: Janssen Biotech, Inc.

Inventor： Kyle J. Bednar ,  Naresh Kumar ,  Sanjaya Singh ,  Danlin Yang ,  Rajkumar Ganesan

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/46

Abstract: Provided herein are multispecific antibodies, that bind to CD79b and CD22, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US20250043019A1

公开(公告)日：2025-02-06

申请号：US18811332

申请日：2024-08-21

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  Anna Kuchnio ,  Cassandra L. Lowenstein ,  Ulrike Philippar ,  Sanjaya Singh ,  Nele Vloemans ,  Danlin Yang

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: Provided herein are multispecific antibodies, including trispecific antibodies that bind to CD79b, CD20 and CD3, and bispecific antibodies that bind to CD79b and CD3, and multispecific antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided multispecific antibodies or multispecific antigen-binding fragments, cells expressing the provided multispecific antibodies or multispecific antigen-binding fragments, as well as associated vectors and detectably labeled multispecific antibodies or multispecific antigen-binding fragments. In addition, methods of producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described. Further provided herein are isolated antibodies that bind to CD79b and antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided CD79b-specific antibodies or antigen-binding fragments, cells expressing the provided CD79b-specific antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled CD79b-specific antibodies or antigen-binding fragments. In addition, methods of producing and using the provided CD79b-specific antibodies and antigen-binding fragments are described.

公开(公告)号：US12180278B2

公开(公告)日：2024-12-31

申请号：US17702042

申请日：2022-03-23

Applicant: Janssen Biotech, Inc.

Inventor： Kyle J. Bednar ,  Naresh Kumar ,  Sanjaya Singh ,  Danlin Yang ,  Rajkumar Ganesan

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/46

Abstract: Provided herein are multispecific antibodies, that bind to CD79b and CD22, polynucleotides encoding them, vectors, host cells, methods of making and using them.